Enhanced glucose production by the liver contributes to hyperglycemia in individuals with diabetes. The purpose of this research was to explore how resistance training influences serum insulin levels, fasting glucose, insulin sensitivity, and TCF7L2 gene expression in the liver cells of rats with type 2 diabetes (T2D). To achieve this aim, T2D was induced in 14 male Wistar rats, aged 10 weeks, through an 8-week high-fat diet combined with streptozotocin (STZ) administration. Subsequently, these rats were randomly divided into two groups: an exercise group that underwent resistance training for 8 weeks, five times per week (n = 7), and a control group that did not receive any training (n = 7). 48 hours following the final training session, all rats underwent dissection. Measurements were taken for TCF7L2 gene expression, glucose, insulin, and insulin resistance, and these metrics were statistically analyzed using an independent t-test between two groups. The data indicated that, relative to the control group, resistance training significantly reduced glucose levels (P = 0.001) and insulin resistance (P = 0.009), while it increased serum insulin levels (P = 0.035) and TCF7L2 gene expression in hepatocytes (P = 0.011). Based on these finding, improved glucose and insulin resistance following resistance training in T2D can be attributed to enhance TCF7L2 gene expression in hepatocytes by training. پرونده مقاله