تاثیر درمانی ماربوفلوکساسین بر ورم‌پستان ناشی از اشریشیاکولای در گاوهای شیری
محورهای موضوعی :
آسیب شناسی درمانگاهی دامپزشکی
جواد رحیمیان
1
(دانش‌آموخته دکترای حرفه‌ای دامپزشکی، دانشکده دامپزشکی، واحد شبستر، دانشگاه آزاد اسلامی، شبستر، ایران.)
جلال شایق
2
(استادیار گروه پاتوبیولوژی، دانشکده دامپزشکی، واحد شبستر، دانشگاه آزاداسلامی، شبستر، ایران.)
امیر علی گلزاری
3
(دامپزشک بخش خصوصی، شرکت دامپروری آذربایجان خاوری، شبستر، ایران.)
تاریخ دریافت : 1398/09/18
تاریخ پذیرش : 1399/12/27
تاریخ انتشار : 1399/11/01
کلید واژه:
اشریشیاکولای,
انروفلوکساسین,
ورم‌پستان,
ماربوفلوکساسین,
چکیده مقاله :
تاثیر آنتی‌بیوتیک‌ها بر ورم‌پستان‌های ناشی از باکتری اشریشیاکولای یکی از مخاطرات صنعت دامپروری است. هدف از انجام مطالعه حاضر، بررسی اثر داروی ماربوفلوکساسین به عنوان یک داروی جدید و مقایسه آن با اثرات داروی انروفلوکساسین در ورم‌پستان‌های درجه I و II مربوط به اشریشیاکولای بود. بدین منظور تعداد 90 راس گاو مبتلاء به ورم‌پستان درجه I و II شناسائی و در سه گروه، "آ" درمان با انروفلوکساسین، "ب" درمان با ماربوفلوکساسین، و "پ" به عنوان گروه شاهد با اعمال دارونما، طبقه بندی گردید. گاوهای مذکور تحت تیمار قرار گرفتند. بر اساس یافته‌ها، در گروه ماربوفلوکساسین 28، در گروه انروفلوکساسین 24 و در گروه شاهد 2 مورد از گاو ها درمان شدند. گاوهایی هم که در مدت حداکثر 5 روز، درمان نشدند به عنوان گاوهای درمان ناپذیر در نظر گرفته شدند. نتایج تحلیل آماری داده‌ها، نشان از تاثیر معنی‌دار داروی ماربوفلوکساسین در مقایسه با دو گروه درمان با انروفلوکساسین و شاهد داشت (001/0p <). به نظر می‌رسد که برای درمان گاوهای مبتلا به ورم پستان درجه I و II ناشی از اشریشیا کولای، داروی ماربوفلوکساسین می‌تواند به عنوان یک داروی موثر در مقایسه با انروفلوکساسین مورد استفاده قرار گیرد.
چکیده انگلیسی:
Mastitis is one of the economic diseases of the livestock industry, especially breeding dairy cows around the world. The most important bacterium that causes peripheral mastitis is Escherichia coli which can cause mild to severe mastitis. The Effect of antibiotics on mastitis caused by Escherichia coli is one of the dangers of the livestock industry. The aim of this study was to evaluate the efficacy of marbofloxacin as a new drug and compare it with the effects of enrofloxacin on grade I and II mastitis. In this study, 90 cows with mastitis grade I and II were identified and divided into three groups of control, anrofloxacin and marbofloxacin treatments. The cows were then treated and cows that had not been healed for up to 5 days were considered as untreated cows. In the present study 28 cows were treated with marbofloxacin and 24 cases were treated in the Enrofloxacin group and 2 in the control group. The results of statistical analysis showed that the effect of marbofloxacin was statistically significant compared to the two groups. It is recommended to use marbofloxacin as an effective drug in the treatment of mastitis in cows with mastitis I and II as compared to anrofloxacin.Conflict of interest: None declared.
منابع و مأخذ:
Anzabi, Y. and Shaghaghi, S. (2015). In vitro evaluation of antibacterial properties of propolis alcoholic extract on bovine mastitis isolates. Veterinary Clinical Pathology, 9(34): 117-129. [In Persian]
Badiei, A., Aurang A., Ali Reza, B. and Mohsen Z. (2008). The effect of general injection of three drugs, Tylosin, Enrofloxacin and penicillin-streptomycin combination on the incidence of breast swellings in newborn dairy cows, 15th Iranian Veterinary Congress, Tehran, Iranian Veterinary Society. [In Persian]
Boonyayatra, S., Fox, L.K., Besser, T.E., Sawant, A. and Gay, J.M. (2010). Effects of storage methods on the recovery of Mycoplasma species from milk samples. Veterinary Microbiology, 144(1-2): 210-213.
Dosogne, H., Meyer, E., Sturk, A., Van Loon, J., Massart-Leën, A.M. and Burvenich, C. (2002). Effect of enrofloxacin treatment on plasma endotoxin during bovine Escherichia coli mastitis. Inflammation Research, 51(4): 201-205.
Erskine, R.J., Wagner, S. and DeGraves, F.J. (2003). Mastitis therapy and pharmacology. The Veterinary clinics of North America. Food Animal Practice, 19(1): 109-138.
Fang, W. and Pyörälä, S. (1996). Mastitis-causing Escherichia coli: serum sensitivity and susceptibility to selected antibacterials in milk. Journal of Dairy Science, 79(1): 76-82.
Grandemange, E. (2002). Field evaluation of the efficacy of marbofloxacin in the treatment of acute mastitis due to Gram-negative bacteria in the dairy cow. Cattle Practice, 10(1): 57-62.
Grandemange, E., Perrin, P.A., Schwab-Richards, R. and Woehrle, F. (2017). Efficacy of a single injection of marbofloxacin in the treatment of acute E. coli mastitis in lactating dairy cows. Revue de Medecine Veterinaire, 168(10-12): 219-228.
Halasa, T., Huijps, K., Østerås, O. and Hogeveen, H. (2007). Economic effects of bovine mastitis and mastitis management: a review. Veterinary Quarterly, 29(1): 18-31.
Hossieni Nejad, M. and Mashak, Z. (2016). Effects of somatic cell count in subclinical mastitis on raw milk quality in dairy farms of khuzestan province. Veterinary Clinical Pathology. 9(36): 335-345. [In Persian]
House, S.A., Gadomski, A.M. and Ralston, S.L. (2020). Evaluating the placebo status of nebulized normal saline in patients with acute viral bronchiolitis: a systematic review and meta-analysis. JAMA Pediatrics, 174(3): 250-259.
Kaartinen, L., Salonen, M., Älli, L. and Pyörälä, S. (1995). Pharmacokinetics of enrofloxacin after single intravenous, intramuscular and subcutaneous injections in lactating cows. Journal of Veterinary Pharmacology and Therapeutics, 18(5): 336-357.
Kietzmann, M., Braun, M., Schneider, M. and Pankow, R. (2008). Tissue distribution of marbofloxacin after ‘systemic’administration into the isolated perfused bovine udder. The Veterinary Journal, 178(1): 115-118.
Kroemer, S., Galland, D., Guérin-Faublée, V., Giboin, H. and Woehrlé-Fontaine, F. (2011). Survey of marbofloxacin susceptibility of bacteria isolated from cattle with respiratory disease and mastitis in Europe. Veterinary Record, 70(2): 53-53.
Meunier, D.D., Acar, J.F., Martel, J.L., Kroemer, S. and Valle, M. (2004). Seven years survey of susceptibility to marbofloxacin of bovine pathogenic strains from eight European countries. International Journal of Antimicrobial Agents, 24(3): 268-278.
Poutrel, B., Stegemann, M.R., Roy, O., Pothier, F., Tilt, N. and Payne-Johnson, M. (2008). Evaluation of the efficacy of systemic danofloxacin in the treatment of induced acute Escherichia coli bovine mastitis. Journal of Dairy Research, 75(3): 310-318.
Rantala, M., Kaartinen, L., Valimaki, E., Stryrman, M., Hiekkaranta, M., Niemi, A., et al. (2002). Efficacy and pharmacokinetics of enrofloxacin and flunixinmeglumine for treatment of cows with experimentally induced Escherichia coli mastitis. Journal of Veterinary Pharmacology and Therapeutics, 25(4): 251-258.
Roberson, J.R. (2012). Treatment of clinical mastitis. Veterinary Clinics: Food Animal Practice, 28(2): 271-288.
Schlegelova, J., Babak, V., Klimova, E., Lukasova, J., Navratilova, P., Sustackova, A., et al. (2002). Prevalence of and resistance to antimicrobial drugs in selected microbial species isolated from bulk milk samples. Journal of Veterinary Medicine, Series B, 49(5): 216-225.
Schneider, M., Valle, M., Woehrlé, F. and Boisrame, B. (2004). Pharmacokinetics of marbofloxacin in lactating cows after repeated intramuscular administrations and pharmacodynamics against mastitis isolated strains. Journal of Dairy Science, 87(1): 202-211
Shem‐Tov, M., Rav‐Hon, O., Ziv, G., Lavi, E., Glickman, A. and Saran, A. (1998). Pharmacokinetics and penetration of danofloxacin from the blood into the milk of cows. Journal of Veterinary Pharmacology and Therapeutics, 21(3): 209-213.
Shokohi M., Ahmadizadeh Ch. and Kaveh A. (2018). Evaluation of bacterial causes of subclinical mastitis in dairy cattle of negine sabze makoo agro-industrial and animal husbandry complex. Veterinary Clinical Pathology, 11(44): 379-388. [In Persian]
Suojala, L., Simojoki, H., Mustonen, K., Kaartinen, L. and Pyörälä, S. (2010). Efficacy of enrofloxacin in the treatment of naturally occurring acute clinical Escherichia coli mastitis. Journal of Dairy Science, 93(5): 1960-1969.
Watts, J.L. (1988). Etiological agents of bovine mastitis. Veterinary microbiology, 16(1): 41-66.
Wenz, J.R., Barrington, G.M., Garry, F.B., McSweeney, K.D., Dinsmore, R.P., Goodell, G. et al. (2001). Bacteremia associated with naturally occurring acute coliform mastitis in dairy cows. Journal of the American Veterinary Medical Association, 219(7): 976-981.
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Anzabi, Y. and Shaghaghi, S. (2015). In vitro evaluation of antibacterial properties of propolis alcoholic extract on bovine mastitis isolates. Veterinary Clinical Pathology, 9(34): 117-129. [In Persian]
Badiei, A., Aurang A., Ali Reza, B. and Mohsen Z. (2008). The effect of general injection of three drugs, Tylosin, Enrofloxacin and penicillin-streptomycin combination on the incidence of breast swellings in newborn dairy cows, 15th Iranian Veterinary Congress, Tehran, Iranian Veterinary Society. [In Persian]
Boonyayatra, S., Fox, L.K., Besser, T.E., Sawant, A. and Gay, J.M. (2010). Effects of storage methods on the recovery of Mycoplasma species from milk samples. Veterinary Microbiology, 144(1-2): 210-213.
Dosogne, H., Meyer, E., Sturk, A., Van Loon, J., Massart-Leën, A.M. and Burvenich, C. (2002). Effect of enrofloxacin treatment on plasma endotoxin during bovine Escherichia coli mastitis. Inflammation Research, 51(4): 201-205.
Erskine, R.J., Wagner, S. and DeGraves, F.J. (2003). Mastitis therapy and pharmacology. The Veterinary clinics of North America. Food Animal Practice, 19(1): 109-138.
Fang, W. and Pyörälä, S. (1996). Mastitis-causing Escherichia coli: serum sensitivity and susceptibility to selected antibacterials in milk. Journal of Dairy Science, 79(1): 76-82.
Grandemange, E. (2002). Field evaluation of the efficacy of marbofloxacin in the treatment of acute mastitis due to Gram-negative bacteria in the dairy cow. Cattle Practice, 10(1): 57-62.
Grandemange, E., Perrin, P.A., Schwab-Richards, R. and Woehrle, F. (2017). Efficacy of a single injection of marbofloxacin in the treatment of acute E. coli mastitis in lactating dairy cows. Revue de Medecine Veterinaire, 168(10-12): 219-228.
Halasa, T., Huijps, K., Østerås, O. and Hogeveen, H. (2007). Economic effects of bovine mastitis and mastitis management: a review. Veterinary Quarterly, 29(1): 18-31.
Hossieni Nejad, M. and Mashak, Z. (2016). Effects of somatic cell count in subclinical mastitis on raw milk quality in dairy farms of khuzestan province. Veterinary Clinical Pathology. 9(36): 335-345. [In Persian]
House, S.A., Gadomski, A.M. and Ralston, S.L. (2020). Evaluating the placebo status of nebulized normal saline in patients with acute viral bronchiolitis: a systematic review and meta-analysis. JAMA Pediatrics, 174(3): 250-259.
Kaartinen, L., Salonen, M., Älli, L. and Pyörälä, S. (1995). Pharmacokinetics of enrofloxacin after single intravenous, intramuscular and subcutaneous injections in lactating cows. Journal of Veterinary Pharmacology and Therapeutics, 18(5): 336-357.
Kietzmann, M., Braun, M., Schneider, M. and Pankow, R. (2008). Tissue distribution of marbofloxacin after ‘systemic’administration into the isolated perfused bovine udder. The Veterinary Journal, 178(1): 115-118.
Kroemer, S., Galland, D., Guérin-Faublée, V., Giboin, H. and Woehrlé-Fontaine, F. (2011). Survey of marbofloxacin susceptibility of bacteria isolated from cattle with respiratory disease and mastitis in Europe. Veterinary Record, 70(2): 53-53.
Meunier, D.D., Acar, J.F., Martel, J.L., Kroemer, S. and Valle, M. (2004). Seven years survey of susceptibility to marbofloxacin of bovine pathogenic strains from eight European countries. International Journal of Antimicrobial Agents, 24(3): 268-278.
Poutrel, B., Stegemann, M.R., Roy, O., Pothier, F., Tilt, N. and Payne-Johnson, M. (2008). Evaluation of the efficacy of systemic danofloxacin in the treatment of induced acute Escherichia coli bovine mastitis. Journal of Dairy Research, 75(3): 310-318.
Rantala, M., Kaartinen, L., Valimaki, E., Stryrman, M., Hiekkaranta, M., Niemi, A., et al. (2002). Efficacy and pharmacokinetics of enrofloxacin and flunixinmeglumine for treatment of cows with experimentally induced Escherichia coli mastitis. Journal of Veterinary Pharmacology and Therapeutics, 25(4): 251-258.
Roberson, J.R. (2012). Treatment of clinical mastitis. Veterinary Clinics: Food Animal Practice, 28(2): 271-288.
Schlegelova, J., Babak, V., Klimova, E., Lukasova, J., Navratilova, P., Sustackova, A., et al. (2002). Prevalence of and resistance to antimicrobial drugs in selected microbial species isolated from bulk milk samples. Journal of Veterinary Medicine, Series B, 49(5): 216-225.
Schneider, M., Valle, M., Woehrlé, F. and Boisrame, B. (2004). Pharmacokinetics of marbofloxacin in lactating cows after repeated intramuscular administrations and pharmacodynamics against mastitis isolated strains. Journal of Dairy Science, 87(1): 202-211
Shem‐Tov, M., Rav‐Hon, O., Ziv, G., Lavi, E., Glickman, A. and Saran, A. (1998). Pharmacokinetics and penetration of danofloxacin from the blood into the milk of cows. Journal of Veterinary Pharmacology and Therapeutics, 21(3): 209-213.
Shokohi M., Ahmadizadeh Ch. and Kaveh A. (2018). Evaluation of bacterial causes of subclinical mastitis in dairy cattle of negine sabze makoo agro-industrial and animal husbandry complex. Veterinary Clinical Pathology, 11(44): 379-388. [In Persian]
Suojala, L., Simojoki, H., Mustonen, K., Kaartinen, L. and Pyörälä, S. (2010). Efficacy of enrofloxacin in the treatment of naturally occurring acute clinical Escherichia coli mastitis. Journal of Dairy Science, 93(5): 1960-1969.
Watts, J.L. (1988). Etiological agents of bovine mastitis. Veterinary microbiology, 16(1): 41-66.
Wenz, J.R., Barrington, G.M., Garry, F.B., McSweeney, K.D., Dinsmore, R.P., Goodell, G. et al. (2001). Bacteremia associated with naturally occurring acute coliform mastitis in dairy cows. Journal of the American Veterinary Medical Association, 219(7): 976-981.
