Effect of 8 weeks moderate intensity aerobic exercise on brain derived neurotrophic factor (BDNF) in female athletes
محورهای موضوعی : Journal of Physical Activity and Hormones
Roya Zare Mehrjardi
1
(MS in Exercise physiology, Education Administration in Asaluyeh)
کلید واژه: Insulin resistance, Aerobic exercise, BDNF, Female athletes,
چکیده مقاله :
Introduction: The effects of exercise training on serum BDNF is still unclear, thus the purpose of this study was to examine the effects of 8 weeks moderate intensity aerobic exercise on serum BDNF levels in female athletes. Material & Methods: Twenty female karate athletics were randomly assigned to one of the exercise group (n=10) or control group (n=10). The training group performed endurance training 3 days a week for 8 weeks at an intensity corresponding to 50-60% individual maximum oxygen consumption for 45 min. Results: Body mass and BMI increased (P<0.05) after 8 weeks aerobic exercise compared to the control group. For WHR, body fat percentage and maximal oxygen consumption there were no significant differences between the exercise group and the control group. There were virtually no changes in body fat percentage, fasting glucose, insulin, insulin resistance and BDNF levels after 8 weeks training. Conclusions: Serum BDNF level was not affected by 8-week moderate intensity aerobic exercise in female athletes.
1. Sattar N, Gaw A, Scherbakova O, Ford I, O'Reilly DS, Haffner SM, et al. Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary Prevention Study. Circulation 2003; 108: 414-419.
2. Gami AS, Witt BJ, Howard DE, Erwin PJ, Gami LA, Somers VK, et al. Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies. J Am Coll Cardiol 2007; 49: 403-414.
3. Hwang LC, Bai CH, Chen CJ. Prevalence of obesity and metabolic syndrome in Taiwan. J Formos Med Assoc 2006; 105: 626-635.]
4. Mozumdar A, Liguori G. Persistent increase of prevalence of metabolic syndrome among U.S. adults: NHANES III to NHANES 1999-2006. Diabetes Care 2011; 34: 216-219.
5. Nikolopoulou A, Kadoglou NP. Obesity and metabolic syndrome as related to cardiovascular disease. Expert Rev Cardiovasc Ther 2012; 10: 933-939.
6. Roberson LL, Aneni EC, Maziak W, Agatston A, Feldman T, Rouseff M, et al. Beyond BMI: The “Metabolically healthy obese” phenotype & its association with clinical/subclinical cardiovascular disease and all-cause mortality-a systematic review. BMC Public Health 2014; 14: 14.
7. Kramer CK, Zinman B, Retnakaran R. Are metabolically healthy overweight and obesity benign conditions? A systematic review and meta-analysis. Ann Intern Med 2013; 159: 758-769.
8. Seligman BG, Polanczyk CA, Santos AS, Foppa M, Junges M, Bonzanini L, et al. Intensive practical lifestyle intervention improves endothelial function in metabolic syndrome independent of weight loss: a randomized controlled trial. Metabolism 2011; 60: 1736-1740.
9. Chiaramello S, Dalmasso G, Bezin L, Marcel D, Jourdan F, Peretto P, et al. BDNF/TrkB interaction regulates migration of SVZ precursor cells via PI3-K and MAP-K signalling pathways. Europ J Neurosci 2007; 26: 1780-1790.
10. Nakagawa T, Tsuchida A, Itakura Y, Nonomura T, Ono M, Hirota F, et al. Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice. Diabetes 2000; 49: 436-444.
11. Suwa M, Kishimoto H, Nofuji Y, Nakano H, Sasaki H, Radak Z, et al. Serum brain-derived neurotrophic factor level is increased and associated with obesity in newly diagnosed female patients with type 2 diabetes mellitus. Metabolism 2006; 55: 852-857.
12. Golden E, Emiliano A, Maudsley S, Windham BG, Carlson OD, Egan JM, et al. Circulating brain-derived neurotrophic factor and indices of metabolic and cardiovascular health: data from the Baltimore Longitudinal Study of Aging. PLoS One 2010; 5: e10099.
13. Krabbe KS, Nielsen AR, Krogh-Madsen R, Plomgaard P, Rasmussen P, Erikstrup C, et al. Brain-derived neurotropic factor (BDNF) and type 2 diabetes. Diabetologia 2006; 50: 431-438.
14. Lommatzsch M, Zingler D, Schuhbaeck K, Schloetcke K, Zingler C, Schuff- Werner P, et al. The impact of age, weight and gender on BDNF levels in human platelets and plasma. Neurobiol Aging 2005; 26: 115-123.
15. Tonra JR, Ono M, Liu X, Garcia K, Jackson C, Yancopoulos GD, et al. Brain-derived neurotrophic factor improves blood glucose control and alleviates fasting hyperglycemia in C57BLKS-Lepr(db)/lepr(db) mice. Diabetes 1999; 48: 588-594.
16. Correia PR, Pansani A, Machado F, Andrade M, Silva AC, Scorza FA. Acute strength exercise and the involvement of small or large muscle mass on plasma brain-derived neurotrophic factor levels. Clinics 2010; 65: 1123-1126.
17. Zoladz IA, Pile A, Majerczak I, Grandys M, Zapart-Bukowska I, Duda K. Endurance training increases plasma brain-derived neurotrophic factor concentration in young healthy men. J Physiol Pharmacol 2008; 59: 119-132.
18. ACSM. ACSM guidelines for exercise testing and prescription. 7th ed. Philadelphia: Lippincott, Williams and Wilkins 2005; PP: 21-30.
19. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419.
20. Fujinami A, Ohta K, Obayashi H, Fukui M, Hasegawa G, Nakamura N et al., Serum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus: relationship to glucose metabolism and biomarkers of insulin resistance. Clin Biochem 2008; 41: 812-817.
21. Lee IT, Wang JS, Fu CP, Lin SY, Sheu WH. Relationship between body weight and the increment in serum brain-derived neurotrophic factor after oral glucose challenge in men with obesity and metabolic syndrome: A prospective study. Medicine (Baltimore) 2016; 95: e5260.
22. Tang SW, Chu E, Hui T, Helmeste D, Law C. Influence of exercise on serum brain‐derived neurotrophic factor concentrations in healthy human subjects. Neurosci Lett 2008; 431: 62-65.
23. Rasmussen P, Brassard P, Adser H, Pedersen MV, Leick L, Hart E, et al. Evidence for a release of brain‐derived neurotrophic factor from the brain during exercise. Exp Physiol 2009; 94: 10621069.
24. Boyuk B, Degirmencioglu S, Atalay H, Guzel S, Acar A, Celebi A, et al. Relationship between Levels of Brain-Derived Neurotrophic Factor and Metabolic Parameters in Patients with Type 2 Diabetes Mellitus. J Diabetes Res 2014; 2014: 1-6.
