The organic extracts from the leaves of Ficus thonningii Blume, Jatropha tanjorensis J.L Ellis and Saroja and Justicia carnea Lindley as potential nutraceutical antioxidants and functional foods

محورهای موضوعی : Medicinal and Herbal Plants

Kingsley Ijoma ¹ ( Department of Pure and Industrial Chemistry, Faculty of Physical Science, Nnamdi Azikiwe University, Awka, Nigeria )
Vincent Ishmael Ajiwe ² ( Department of Pure and Industrial Chemistry, Faculty of Physical Science, Nnamdi Azikiwe University, Awka, Nigeria )
Stanley Odinma ³ ( Department of Industrial Chemistry, Faculty of Natural Science, Caritas University, Amorji-Nike, Enugu, Nigeria )

تاریخ دریافت : 1401/10/24 تاریخ پذیرش : 1402/01/09 تاریخ انتشار : 1401/12/10

کلید واژه: micronutrients, <i></i>Jatropha tanjorensis J.L Ellis and Saroja, <i></i>Ficus thonningii Blume, Ferric reducing antioxidant power (FRAP), Radical scavenging activity, 1, 1-Diphenyl-2-picrylhydrazyl (DPPH), <i></i>Justicia carnea Lindley,

چکیده مقاله :

The search for naturally occurring plant-based nutraceutical antioxidants is imperative in the management of arrays of diseases. Herein, the methods involved profiling antioxidant activities and nutritional composition of the methanolic extracts from the leaves of Ficus thonningii Blume (FTH), Jatropha tanjorensis J.L Ellis and Saroja (JTR) and Justicia carnea Lindley (JCN) using spectrophotometric techniques. In this sense, J. tanjorensis J.L Ellis and Saroja extract showed the highest total antioxidant capacity and strong DPPH radical scavenging activity with an IC50 of 10.490 ± 0.0320 μg.mL-1 when compared to ascorbic acid (IC50 of 114.140 ± 5.135 μg.mL-1), while for the hydroxyl radical scavenging activity, F. thonningii Blume and J. carnea Lindl. extracts resembled IC50 values of 523.095 ± 13.629 and 503.733 ± 7.562 μg.mL-1, respectively. A positive correlation was observed between the extracts and ascorbic acid (p < 0.001), as well. In addition, nutrients and minerals were present in appreciable quantities. The obtained results validate the assayed plants extracts as potential radical scavengers and promising nutraceutical antioxidants in ethnomedicine.

منابع و مأخذ:

Aiwonegbe, A.E., Omoruyi, U., Ogbeide, O.K., Imoukhuede, B.O., Gabriel, B.O., 2022. Anxiolytic effects, antioxidant and anti-inflammatory activities of the methanol extract of Jatropha tanjorensis leaf. Tanz. J. Sci. 48(3), 596-606.
Akintimehin, E.S., Karigidi, K.O., Omogunwa, T.S., Adetuyi, F.O., 2021. Safety assessment of oral administration of ethanol extract of justicia carnea leaf in healthy Wistar rats: Hematology, antioxidative and histology studies. Clin. Phytosci. 7(2), 1-9.
Aminjan, H.H., Abtahi, S.R., Hazrati, E., Chamanara, M., Jalili, M., Paknejad, B., 2019. Targeting of oxidative stress and inflammation through ROS/NF-kappaB pathway in phosphine-induced hepatoxicity mitigation. Life Sci. 232, 116607.
Antwi-Boasiako, C., Dankwah, G.B., Aryee, R., Hayfron-Benjamin, C., Donkor, S.E., Campbell, A.D., 2019. Oxidative profile of patients with sickle cell disease. Med Sci. (Basel) 7(2), 17.
Awuchi, C.G., Igwe, V.S., Amagwula, I.O., 2020. Nutritional diseases and nutrient toxicities: A systematic review of the diets and nutrition for prevention and treatment. Int. J. Adv. Acad. Res. 6(1), 1-46.
Bello, M.O., Falade, O.S., Adewusi, S.R.A., Olawore, N.O., 2008. Nutrient and antinutrient components of Jatropha tanjorensis (J.L Ellis and Saroja), an unconventional vegetable in Nigeria. Ife J. Sci. 10(1), 27-31.
Chen, X.F., Wang, L., Wu, Y.Z., Song, S.Y., Min, H.Y., Yang, Y., He, X., Liang, Q., Yi, L., Wang, Y., Gao, Q., 2018. Effect of puerarin in promoting fatty acid oxidation by increasing mitochondrial oxidative capacity and biogenesis in skeletal muscles in diabetic rats. Nutr. Diabetes 8, 1-13.
Dangarembizi, R., Erlwanger, K.H., Moyo, D., Chivandi, E., 2013. Phytochemistry, pharmacology and ethnomedicinal uses of Ficus thonningii (Blume Moraceae): A review. Afr. J. Tradit. Complement. Altern. Med. 10(2), 203-212.
Evans, W.C., 2009. Trease and Evans Pharmacognosy. 16th Ed. Saunders Ltd. London, pp. 1-600.
Harborne, J.B., 1998. Phytochemical Methods - A Guide to Modern Techniques of Plant Analysis, 3rd Ed. Chapman and Hall. London, pp. 38-90.
Ijoma, K.I., Ajiwe, V.I.E., 2022. Jatropha tanjorensis a flora of southeast Nigeria: Isolation and characterization of naringenin and validation of bio-enhanced synergistical activity of α-tocopherol toward clinical isolates of resistant bacterial. Makara J. Sci. 26(2), 120-127.
Liu, X., Jia, J., Jing, X., Li, G., 2018. Antioxidant activities of extracts from sarcocarp of Cotoneaster multiflorus. J. Chem. 4619768, 1-7.
Liu, Z.Q., 2019. Bridging free radical chemistry with drug discovery: A promising way of finding novel drug efficiently. Eur. J. Med. Chem. 189, 112020.
Mahdavi, B., Mohammadhosseini, M., 2022. Antioxidant, antimicrobial and anti-prostate cancer activity of extracts from different parts of Etlingera velutina (Ridl.) R. M. Sm (Zingiberaceae). Trends Phytochem. Res. 6(4), 353-362.
Mensor, L., Menezes, F., Leitao, G., Reis, A., Dos Santos, T., Coube, C., Leitão, S.G., 2001. Screening of Brazilian plant extracts for antioxidant activity by the use of DPPH free radical method. Phytother. Res. 15, 27-130.
Nartey, E.B., Spector, J., Adu-Afarwuah, S., Jones, C.L., Jackson, A., Ohemeng, A., Shah, R., Koryo-Dabrah, A., Kuma, A.B., Hyacinth, H.I., Steiner-Asiedu, M., 2021. Nutritional perspectives on sickle cell disease in Africa: A systematic review. BMC Nutr. 7(9), 1-21.
Nurhidayah, R., Noorzafiza, Z., Syarifah, M., Nazar, M.Z., Mahmood, A.A., 2017. Antioxidant Activity of Alstonia angustifolia Ethanolic Leaf Extract. The 2nd International Conference on Applied Science and Technology 2017 (ICAST’17) AIP Conf. Proc. 1891, 020012-1-020012-6.
Okpala, E.O., Onocha, P.A., Ali, M.S., 2022. Antioxidant activity of phytol dominated stem bark and leaf essential oils of Celtis zenkeri Engl. Trends Phytochem. Res. 6(2), 137-144.
Oladele, J.O., Oladele, O.T., Ademiluyi, A.O., Oyeleke, O.M., Awosanya, O.O., Oyewole, O.I., 2020. Chaya (Jatropha tanjorensis) leafs protects against sodium benzoate mediated renal dysfunction and hepatic damage in rats. Clin. Phytosci. 6(13), 1-8.
Oloyede, G.K., Ibok, M.G., Ojo, T.K., 2021. Chemical constituents, antimicrobial and antioxidant activities of Leptoderris brachyptera (Benth.) Dunn and Leptoderris micrantha Dunn essential oils. Trends Phytochem. Res. 5(1), 13-23.
Onyeabo, C.H., Achi, N.K., Ekeleme-Egedigwe, C.A., Ebere, C.U., Okoro, C.K., 2017. Haematological and biochemical studies on Justicia carnea leaves extract in phenylhydrazine induced-anemia in Albino rats. Acta Sc. Pol. Technol. Aliment. 16(2), 217-230.
Orjiakor, C.A., Uroko, R.I., Njoku, O.U., Ezeanyika, L.U.S., 2019. Nutritive properties of aqueous extracts Justicia carnea leaves and its effects on haematological and some biochemical indices of anaemia induced male Wistar rat. Biomed. Res. 30(4), 645-654.
Osowe, C.O., Olowu, O.P.A., Adu, O.A., Oloruntola, O.D., Chineke, C.A., 2021. Proximate and mineral composition phytochemical analysis and antioxidant activity of fig tree (Ficus spp) leaf powder. Asian J. Biochem. Genet. Mol. Biol. 9(1), 19-29.
Oyaizu, M., 1986. Studies on products of browning reaction: Anti-oxidative activities of products of browning reaction prepared from glucosamine. Japan J. Nutr. 44, 307-315.
Pougoue, J.K., Fokunang, E.T., Beringyuy, E.B., Ngoupayo, J., Njinkio, J.A., Fonmboh, J.D., Ngameni, B., Fokunang, N.C., 2020. Evaluation of antioxidant properties of secondary metabolite in aqueous extracts of Ficus thonningii Blume tested on wistar rats. J. Anal. Pharm. Res. 9(1), 27-35.
Prieto, P., Pineda, M., Aguilar, M., 1999. Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: Specific application to the determination of vitamin E. Anal. Biochem. 269, 337-341.
Rahman, M., Islam, B., Biswas, M., Alam, K., 2015. In vitro antioxidant and free radical scavenging activity of different parts of Tabebuia pallida growing in Bangladesh. BMC Res. Notes 8(621), 1-9.
Sharifi-Rad, M., Anil, N.V., Dini, L., Zucca, P., Varoni, E.M., Panzarini E., Rajkovic J., Tsouh P.V., Azzini, E., Peluso, I., Prakash, M.A., Nigam, M., El Rayess Y., Beyrouthy, M.E., Polito, L., Iriti, M., Martins, N., Martirell, M., Docea, A.O., Setzer, WN., Calina D., Cho, W.C., Sharifi-Rad, J., 2020. Life style, oxidative stress, and antioxidants: Back and forth in the pathophysiology of chronic diseases. Front. Physiol. 11(694), 1-21.
Unuofin, J.O., Otunola, G.A., Afolaya, A.J., 2017. Nutritional evaluation of Kedrostis africana (L.) Cogn: An edible wild plant of South Africa. Asian Pac. J. Trop. Biomed. 7(5), 443-449.
Uzomba, T.A., 2022. The Implication of Replacing Synthetic Antioxidant with Natural Ones in the Food Systems, in: Prieto, M.A., Otero, P. (Eds.), Natural Food Additives. IntechOpen London, pp. 1-20.
Vignesh, A., Veerakumari, K.P., Selvakumar, S., Rakkiyappan, R., Vasanth, K., 2021. Nutritional assessment, antioxidant, anti-inflammatory and antidiabetic potential of traditionally used wild plant, Berberis tinctoria Lesch. Trends Phytochem. Res. 5(2), 71-91.
Vona, R., Sposi, N.M., Matta, L., Gambardella, L., Straface, E., Pietraforte, D., 2021. Sickle cell disease: Role of oxidative stress and antioxidant therapy. Antioxidants 10(296), 1-27.
Watz, B., 2008. Anti-inflammatory effects of plant-based foods and of their constituents. Int. J. Vitam. Nutr. Res. 78(6), 293-298.
WHO. Micronutrients. https://www.who.int/health-topics/micronutrients#tab=tab_1. Retrieved 13-12-2022.