مروری بر کاربرد پروبیوتیک ها ومتابولیت های آن در درمان بیماریها
محورهای موضوعی : Biotechnological Journal of Environmental Microorganisms
محدثه لاری پور
1
,
حمیده کربلایی حیدر
2
,
کیمیا بسیجی
3
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مائده ابراهیمی
4
1 - گروه میکروبیولوژی ، دانشکده علوم پایه ، واحد تهران شمال ، دانشگاه آزاد اسلامی ، تهران ، ایران
2 - دانش آموخته ارشد بیوتکنولوژی، دانشکده علوم زیستی، گروه بیوتکنولوژی،دانشگاه آزاد اسلامی ،واحدتهران شمال، تهران، ایران
3 - دانش آموخته ارشد میکروبیولوژی، دانشکده علوم زیستی، گروه بیوتکنولوژی،دانشگاه آزاد اسلامی ،واحدتهران شمال، تهران، ایران
4 - دانش آموخته ارشد میکروبیولوژی، دانشکده علوم زیستی، گروه بیوتکنولوژی،دانشگاه آزاد اسلامی ،واحدتهران شمال، تهران، ایران
کلید واژه: پروبیوتیک, سین بیوتیک, پری بیوتیک, پست بیوتیک,
چکیده مقاله :
دستگاه گوارش انسان حاوی میکروبیوتای غنی و پیچیده ای است که در عملکرد دستگاه گوارشی، فرایندهای ایمونولوژیک و درمسیر برخی از بیماری ها از جمله دیس بیوز نقش مهمی را ایفا می کند. بر طبق تحقیقات مجموعه میکروبیوتای دستگاه گوارش می تواند، بر روی کاهش یا افزایش جمعیت میکروبیوم پوست، دستگاه عصبی و قسمتهای دیگر بدن انسان تأثیر گذار باشد. مصرف مکملهای غذایی فراسودمند به عنوان یک استراتژی بالقوه و امیدوارکننده برای تنظیم میکروبیوتای روده وبهبود بیماری های تحث تأثیر آن در حال ظهور است. انواع مکمل های پروبیوتیک می تواند شامل مخمرها، باکتری ها و انواع پری بیوتیک شامل پلی ساکارید های غیر قابل هضم با منشاء گیاهی، میکروبی، قارچهای کلاهدارو جلبکها باشند. همراه شدن پروبیوتیک ها و پری بیوتیکها منجر به تولید فراورده های سینبیوتیک با اثرات قوی تر در ارتقاء سلامت انسان می شود. علاوه بر این موارد، پست بیوتیک ها محصولات جانبی متابولیک آزاد شده از پروبیوتیک ها می باشند و پس از تجزیه باکتری با اثرات سلامتی زیادی مانند تنظیم سلامت روده و تقویت سیستم ایمنی، مانند پروبیوتیک‌ها مورد استفاده قرار گرفته اند. تا به امروز در مطالعات انجام شده، اثرات افزایش پروبیوتیک های روده و کاهش میکروارگانیسم های بیماریزا پری بیوتیک و اثرات ضد سرطانی ، التهابی و ایمونومدولاتوری پست بیوتیک ها و سین بیوتیک ها بر روی میکروبیوم دستگاه گوارشی اثبات شده لذا تهیه مکمل های فراسودمند ومصرف آنها افزایش پیدا کرده است.
The human gastrointestinal tract includes a rich and complex microbiota that plays an essential role in the functioning of the gastrointestinal tract, immunological processes and the path of some diseases, including dysbiosis. According to research, the gastrointestinal microbiota can increase or decrease the microbiome population of the skin, nervous system, and other human body parts. Consumption of beneficial dietary supplements is emerging as a potential and promising strategy for regulating the intestinal microbiota and improving its effects. Probiotic supplements can include yeasts, bacteria, and prebiotics, including indigestible polysaccharides of plant, microbial, fungal, and algal origin. The combination of probiotics and prebiotics leads to the production of synbiotic products with stronger effects in improving human health. In addition, postbiotics are metabolic byproducts released from probiotics and, after bacterial degradation, has several beneficial impacts such as regulating intestinal health and strengthening the immune system, like probiotics.
Conclusion: To date, studies have proven the effects of increasing intestinal probiotics, the use of prebiotics and the anticancer, anti-inflammatory and immunomodulatory effects of postbiotics and synbiotics on the gastrointestinal microbiome. Therefore, the preparation of beneficial supplements and their consumption has increased.
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