The Effect of High Intensity Interval Training on the Response of Coagulation and Fibrinolytic Factors of Hypertensive Patients to One Bout Submaximal Endurance Exercise
محورهای موضوعی : Report of Health Care
Rohollah Valizadeh
1
(Department of Exercise Physiology, Science and Research Branch, Islamic Azad University, Tehran, Iran)
Hojatollah Nikbakht
2
(Department of Exercise Physiology, Science and Research Branch, Islamic Azad University, Tehran, Iran)
Farshad Ghazalian
3
(Department of Exercise Physiology, Science and Research Branch, Islamic Azad University, Tehran, Iran)
Hossein Abednatanzi
4
(Department of Exercise Physiology, Science and Research Branch, Islamic Azad University, Tehran, Iran)
David L.Costill
5
(Department of Exercise Sciences, Human Performance Laboratory, Ball State University, Muncie, Indiana, America)
کلید واژه: Training, Coagulation, Hypertension, Fibrinolytic,
چکیده مقاله :
Introduction: Extensive evidence has shown that high intensity exercise triggers blood coagulation and improves blood fibrinolysis levels. The purpose of the present study was to investigate the effect of 12 weeks of high intensity interval training (HIIT) on the response of coagulation, anticoagulant and fibrinolytic factors of hypertensive cardiovascular patients to one bout submaximal endurance exercise (OBSEE). Methods: Out of 70 men with high blood pressure, 20 men were selected based on inclusion and exclusion criteria and randomly divided into two equal groups: an experimental group (EG) and a control group (CG). First, both groups performed OBSEE. After that, the EG performed 12 weeks of HIIT. At the end, again, both groups performed OBSEE. Blood sampling was performed just before and immediately after each session of exercise. Dependent variables were categorized into three groups including 1. Coagulation: fibrinogen(FIB), factor VIII(FVIII), prothrombin time (PT), prothrombin time activity (PTA), international normalized ratio (INR), activated partial thromboplastin time (aPTT), platelet (PLT), mean platelet volume (MPV) 2. Anticoagulation: protein C (PC), antithrombinIII (ATIII) 3. Fibrinolytic: d-dimer (D-D), tissue plasminogen activator (tPA), plasminogen activator inhibitor1 (PAI-I), tPA/PAI-1. To analyze the data, Shapiro- Wilk test, Factorial repeated measures ANOVA, as well as Pearson correlation coefficient were used at significant level (P ≤ 0.05). Results: HIIT caused significant increase in the rate of Vo2max (p = 0.001) and significant decrease in RHR (p = 0.001), SBP (p = 0.001) and DBP (p = 0.001). No significant difference was observed between the two groups in the response of FIB (p = 0.262), FVIII (p = 0.248), PT (p = 0.396), PTA (p = 0.646), INR (p = 0.408), aPTT (p = 0.856), PLT (p = 0.678), MPV (p = 0.223), D-D (p = 0.621), tPA (p = 0.381), PAI-1 (p = 0.353), tPA / PAI-1 (p = 0.069), PC (p = 0.147) and ATIII (p = 0.138) to OBSEE after 12 weeks HIIT. Conclusion: It seems that to observation of significant positive changes in the response of coagulation, anticoagulant, and fibrinolytic factors to one OBSEE, more than 12 weeks HIIT are required.
1. Elaine NM, Katja H. Human anatomy& physiology. (9th Ed). Upper Saddle River, United States: Pearson. 2013.
2. Beevers DG, Lip G, Brien EO. ABC of hypertension. (6th Ed). Oxford, London: BMJ Books. 2015.
3. Smith DL, Fernhall B. Advanced cardiovascular exercise physiology. Human Kinetics. 2011.
4. Nadar S, Lip G. Hypertension. (2th Ed). Oxford University Press. 2015.
5. Buttar HS, Li T, Ravi N. Prevention of cardiovascular diseases: Role of exercise, dietary interventions, obesity and smoking cessation. Exp Clin Cardiol. 2005; 10 (4): 229- 249.
6. Gielen S, Schuler G, Adams V. Cardiovascular effects of exercise training molecular mechanisms. Circ J. 2010; 122: 1221- 1238.
7. Thinkham MH. Health promotion in cardiac rehabilitation patients through the use of a high- intensity interval training protocol. WJCD. 2014; 4: 493- 497.
8. Guiraud T, Nigam A, Gremeaux V, Meyer PH, Juneau M, Bosquet L. High- intensity interval training in cardiac rehabilitation. Sports Med. 2012; 42 (7): 587- 605.
9. Ciolac EG. High- intensity interval training and hypertension: maximizing the benefits of exercise?, Am J Cardiovasc Dis. 2012; 2 (2): 102- 110.
10. Biskey LM. Effects of high intensity interval training on hemostasis and fibrinolysis in healthy males: relationship to sympathetic nervous system activation. MSc thesis in University of Toronto. 2015.
11. Heyward VH, Gibson AL. Advanced fitness assessment and exercise prescription. 7th Ed. New Mexico: J Hum Kinet. 2014.
12. Hilberg T, Menzel K, Wehmeier UF. Endurance training modifies exercise-induced activation of blood coagulation. Eur J Appl Physiol. 2013; 113 (6): 1423- 1430.
13. Graham T, Deirdre L, Douglas C, Gregory YHL. A systematic review of the effects of acute psychological stress and physical activity on haemorheology, coagulation, fibrinolysis and platelet reactivity: Implications for the pathogenesis of acute coronary syndromes. Thromb Res. 2007; 120 (6): 819- 847.
14. Nascimento DC, Neto FR, Santana FS, Silva RAS, Santos-Neto, LD, et al. The interactions between hemostasis and resistance training: a review. Int J Gen Med. 2012; 5: 249- 254.
15. Patelis N, Karaolanis G, Kouvelos GN, Hart C, Metheiken S. The effect of exercise on coagulation and fibrinolysis factors in patients with peripheral arterial disease. Exp Biol Med. 2016; 241: 1699- 1707.
16. Sharief KM, Hassan HA, Osman H, Ahmed AS. Ejection fraction rate for hypertensive patients using echocardiography. Med Res Chron. 2015; 2 (3): 322- 329.
17. Jette M, Sidney K, Blumchen G. Metabolic equivalents (METS) in exercise testing, exercise prescription, and evaluation of functional capacity. Clin Cardiol. 1990; 13: 555- 565.
18. Lakhdar N, Saad HB, Denguezli M, Zaouali M, Zbidi A, Tabka Z. Effects of intense cycling training on plasma leptin and adiponectin and its relation to insulin resistance. Neuro Endocrinol Lett. 2013; 34 (3): 229- 235.
19. Ahmadizad S, Moradi A, Nikookheslat S, EbrahiMI H, Rahbaran A, Connes PH. Effects of age on hemorheological responses to acute endurance exercise. ESCHM. 2011; 49 (1- 4): 165- 174.
20. Patel N. Why is EDTA the anticoagulant of choice for hematology use?. Tech Talk. 2009; 7 (1): 1- 7.
21. Hnasko R. Elisa methods and protocols. Humana Press. 2015.
22. Antovic JP, Blomback M. Essential guide to blood coagulation. Wiley- Blackwell. 2010.
23. Plowman SHA, Smith DL. Exercise physiology for health fitness and performance. (4th Ed). Philadelphia: Lippincott Williams & Wilkins. 2015.
24. Alis R, Sanchis-Gomar F, Primo-Carrau C, Lozano-Calve S, Dipalo M, Aloe R et al. Hemoconcentration induced by exercise: Revisiting the Dill and Costill equation. Scand J Med Sci Sports. 2015; 25 (6): e630- 637.
25. Dill DB, Costill DL. Calculation of percentage changes in volumes of blood plasma and red cells in dehydration. J Appl Physiol. 1974; 37 (2): 247- 248.
26. Emaus A, Wilsgaard T, Furberg AS, Thune I. Blood pressure, cardiorespiratoty fitness and body mass: Result from the Tromso Activity study. Norsk Epidemiologi. 2011; 2 (20): 189- 197.
27. Montero D. The association of cardiorespiratory fitness with endothelial or smooth muscle vasodilator function. Eur J Prev Cardio. 2015; 22 (9): 1200- 1211.
28. Eldour AAA, Khalafallah TO, Noja HM, Saad ESM, Elsayid M, Babker AMAAA. Fibrinogen levels in hypertensive and normotensive: a cross- sectional from El-obied city, sudan. J Biosci Med. 2016; 4: 28- 32.
29. Aziz CA, Omar N, Abdullah WZ, Jalil RA, Nik WW, Zakaria R. Reduced
fibrinogen, fibrinolytic biomarkers, and physical parameters after a weight-loss program in obese subjects. North Am J Med Sci. 2014; 6 (8): 377- 382.
30. Cortes- Canteli M, Zamolodchikov D, Jin Ahn HA, Strickland S, Norris EH. Fibrinogen and altered hemostasis in alzheimer's disease. J Alzheimers Dis. 2012; 32 (3): 599- 608.
31. Chitsaz A, Mousavi SA, Yousef Y, Mostafa V. Comparison of changes in serum fibrinogen level in primary intracranial hemorrhage (ICH) and ischemic stroke. ARYA Atheroscler. 2012; 7 (4): 142- 145.
32. Tabak O, Gelisgen R, Uzun H, Kalender B, Balci H, Curgunlu A, et al. Hypertension and hemostatic/ fibrinolytic balance disorders. Clin Invest Med. 2009; 32 (6): E285- E292.
33. Shankar A, Wang JJ, Rochtchina E, Mitchell P. Positive association between plasma fibrinogen and incident hypertension among men. population-based cohort study. Hypertension J. 2006; 48 (6): 1043- 1049.
34. Charalambos V, Panagiota P, Konstantions A, Gregory V, Carmen V, Athanasios B, et al. Relationship of fibrinogen with arterial stiffness and wave reflections. J Hypertens. 2007; 25 (10): 2110- 2116.
35. Ikeda Y, Iwanaga S, Saito H, Katsuo S, Tanaka K, Davie EW. Recent advances in thrombosis and hemostasis. Springer. 2008.
36. Tarsia J, Chang TR, Aysenne A, Boehme AK, Sartor AE, Albright KC, et al. Elevated plasma factor VIII in patients with ischemic stroke: does it have any association with hypertensive heart disease?. J Neurol Disord Stroke. 2013; 1 (3): 1027.
37. Denuijl IEM, Groen WG, Der Net JJV, Grobbee DE, De Groot, PG, Fischer K. effects of exercise in non- severe haemophilia patients. Blood J. 2010; 116: 545.
38. Lichtin A, Bartholomew J. The coagulation consult: a case- based guide. Springer. 2014.
39. Pan J, Dinh TT, Rajaraman A, Lee M, Scholz A, Czupalla CJ, et al. Patterns of expression of factor VIII and von Willebrand factor by endothelial cell subsets in vivo. Blood J. 2016; 128 (1): 104- 109.
40. Ribeiro J, Almeida-Dias A, Ascensao A, Magalhaes J, Oliveira AR, Carlson J, et al. Response to acute physical exercise in healthy adolescents. J Sci Med Sport. 2007; 10: 164- 169.
41. Gresele P, Fuster V, Lopez J, Page CP, Vermylen J. Platelets in hematologic and cardiovascular disorders. Cambridge University Press. 2008.
42. Longo DL. Harrison's hematology and oncology. (17th Ed). McGraw- Hill Companies. 2010.
43. Shaz BH, Hillyer CD, Abrams CS, Roshal M. Transfusion medicine and hemostasis. clinical and laboratory aspects. (2nd Ed). Elsiver. 2013.
44. Guyton AC, Hall JE. Medical physiology. 13th Ed. Philadelphia: Elsiver. 2016.
