Unveiling the potential antidiabetic, antidyslipidemic, and antimicrobial effects of methanolic root extracts of Nymphaea pubescens Willd. plant: Evidence from in-vitro and in-vivo approaches
محورهای موضوعی : Phytochemistry: Isolation, Purification, Characterization
Sahid Ahmad Santo
1
,
Tanmay Deb
2
,
Md. Abdus Salam
3
,
Arafat Miah
4
,
Md. Saddam Hussain
5
,
Anamika Datta
6
,
Mohammad Nurul Amin
7
,
Mohammad Sarowar Uddin
8
,
Mohammad Safiqul Islam
9
,
Md. Shalahuddin Millat
10
1 - Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
2 - Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
3 - Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
4 - Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
5 - Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
6 - Department of Pharmacy, R. P. Shaha University, Narayanganj-1400, Bangladesh
7 - Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka-1230, Bangladesh
8 - Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
9 - Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
10 - Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
کلید واژه: Antidiabetic, Antihyperlipidemic, Antimicrobial, In vitro, In vivo, Nymphaea pubescens Willd., Nymphaeaceae ,
چکیده مقاله :
This study investigated the therapeutic potential of methanolic root extracts of Nymphaea pubescens Willd. with a focus on their antidiabetic, antilipidemic, and antimicrobial properties. The methanolic root extracts of the N. pubescens at higher doses (500 mg/kg) exhibited a pronounced serum blood glucose-lowering activity (p < 0.001) and also demonstrated remarkable outcomes in body weight loss (p < 0.01), closely resembling the effects of the standard metformin. The same experiment displayed a noticeable reduction in low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) levels (p < 0.001), along with a notable elevation in high-density lipoprotein cholesterol (HDL-C) levels (p < 0.01). Furthermore, the plant extract at 500 mg/kg unveiled significant antimicrobial activities (p < 0.001) against both Staphylococcus aureus and Aspergillus niger and also exhibited significant (p < 0.01) inhibition of Escherichia coli. In summary, these findings highlight the multifaceted therapeutic potential of N. pubescens root extracts, warranting further investigation for their possible development into novel therapeutic agents.
This study investigated the therapeutic potential of methanolic root extracts of Nymphaea pubescens Willd. with a focus on their antidiabetic, antilipidemic, and antimicrobial properties. The methanolic root extracts of the N. pubescens at higher doses (500 mg/kg) exhibited a pronounced serum blood glucose-lowering activity (p < 0.001) and also demonstrated remarkable outcomes in body weight loss (p < 0.01), closely resembling the effects of the standard metformin. The same experiment displayed a noticeable reduction in low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) levels (p < 0.001), along with a notable elevation in high-density lipoprotein cholesterol (HDL-C) levels (p < 0.01). Furthermore, the plant extract at 500 mg/kg unveiled significant antimicrobial activities (p < 0.001) against both Staphylococcus aureus and Aspergillus niger and also exhibited significant (p < 0.01) inhibition of Escherichia coli. In summary, these findings highlight the multifaceted therapeutic potential of N. pubescens root extracts, warranting further investigation for their possible development into novel therapeutic agents.
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