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کد مقاله : ASCIJ-2306-1505 (R1) بازدید : 345 صفحه: 203 - 218

10.22034/ascij.2023.1989804.1505

نوع مقاله: پژوهشی

مروری برکاربرد نانوذرات کیتوسان در درمان انواع سرطان و بررسی سمیت سلولی آنها

محورهای موضوعی : فصلنامه زیست شناسی جانوری

الهام رستمی 1

1 - گروه شیمی، دانشکده علوم، دانشگاه شهید چمران اهواز، اهواز، ایران

تاریخ دریافت : 1402/04/04 تاریخ پذیرش : 1402/06/12 تاریخ انتشار : 1402/12/01

کلید واژه: کیتوسان, نانوذرات, سمیت سلولی, انتقال هدفمند دارو,

چکیده مقاله :

کیتوسان یکی از مناسب‌ترین بیوپلیمرها با امکانات گسترده برای بهبود بخشیدن ویژگی‌های جدید نانو دارو و استفاده در زمینه‌های زیست دارویی است که از کیتین دی‌استیل و آمینو‌پلی‌ساکارید ساخته شده است. ویژگی‌های متنوع دارو از جمله خاصیت کاتیونی و رهایش کنترل شده به دلیل وجود گروه عاملی آمینی نوع اول در کیتوسان است. این ویژگی‌های عالی، زیست‌سازگاری، زیست‌تخریب پذیری و ظرفیت بارگذاری، راه‌حل کارآمدی برای جلوگیری از واکنش‌های نامطلوب می‌باشند. با اصلاح نانوذرات کیتوسان که بطور رایج به عنوان حامل دارو تولید و استفاده می‌شوند، سمیت و عوارض جانبی ناشی از تجویزات کاهش داده می‌شوند. دستیابی به رسانش هدفمند دارو، با استفاده از پپتید‌ها، آنتی‌بادی ها، آپتامر یا مولکول‌های کوچک میسر می‌شود. روش‌های ذکر شده دوز میزان استفاده از داروی لازم را کاهش می‌دهند. بعلاوه، آنها دارو را به سمت بافت هدف هدایت می‌کنند. این مقاله مروری با هدف نشان دادن اهمیت ویژگی‌های نانوذرات متصل به آنتی‌بادی، مغناطیسی، کیتوسان مزدوج حساس به pH، در انتقال هدفمند دارو انجام شد. همچنین اثر انواع این نانوذرات بر رده‌های مختلف سلول‌های سرطانی، سمیت سلولی انواع نانوذرات و فارماکوکینتیک آنها مورد بررسی قرار گرفته است. روش گردآوری اطلاعات استفاده از پایگاه های علمی Scopus، Elsevier و PubMed می باشد.

چکیده انگلیسی:

Chitosan, made of deacetylated of chitin and the amino polysaccharide, is one of the greatest convenient biopolymers, which has large possibilities to be modified for new features of nano-medicine and being used in biomedical fields. Having responsibility of various features such as cationic nature and controlled drug release, are to the primary amine functional groups in chitosan. There are great properties, such as biocompatibility, biodegradability, loading capacity and an efficient way to avoid undesirable reactions, since the toxicity and side effects of systemic administration are reduced by adjusting Chitosan NPs, they are commonly synthesized as drug carriers. Achieving targeted delivery of drug is due to using peptides, antibodies, aptamer or small molecules. Mentioned methods lower using dosage of adequate drugs. Additionally, they lead the drugs to the targets. Also, the cytotoxicity studies of various nanoparticles and their pharmacokinetic studies have been carried out. The purpose of this review article is to show the importance of the characteristics of antibody-bound, magnetic, pH-sensitive conjugated chitosan nanoparticles in targeted drug delivery and to investigate the effect of these nanoparticles on different types of cancer cells.

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