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رقم المقالة : ASCIJ-2306-1505 (R1) زيارة : 287 الصفحة: 203 - 218

10.22034/ascij.2023.1989804.1505

نوع المخطوط: ابحاث

مروری برکاربرد نانوذرات کیتوسان در درمان انواع سرطان و بررسی سمیت سلولی آنها

الموضوعات : فصلنامه زیست شناسی جانوری

الهام رستمی 1 (گروه شیمی، دانشکده علوم، دانشگاه شهید چمران اهواز، اهواز، ایران)

تاريخ الإرسال : 07 الأحد , ذو الحجة, 1444 تاريخ التأكيد : 18 الأحد , صفر, 1445 تاريخ الإصدار : 10 الثلاثاء , شعبان, 1445

الکلمات المفتاحية: کیتوسان, نانوذرات, سمیت سلولی, انتقال هدفمند دارو,

ملخص المقالة :

کیتوسان یکی از مناسب‌ترین بیوپلیمرها با امکانات گسترده برای بهبود بخشیدن ویژگی‌های جدید نانو دارو و استفاده در زمینه‌های زیست دارویی است که از کیتین دی‌استیل و آمینو‌پلی‌ساکارید ساخته شده است. ویژگی‌های متنوع دارو از جمله خاصیت کاتیونی و رهایش کنترل شده به دلیل وجود گروه عاملی آمینی نوع اول در کیتوسان است. این ویژگی‌های عالی، زیست‌سازگاری، زیست‌تخریب پذیری و ظرفیت بارگذاری، راه‌حل کارآمدی برای جلوگیری از واکنش‌های نامطلوب می‌باشند. با اصلاح نانوذرات کیتوسان که بطور رایج به عنوان حامل دارو تولید و استفاده می‌شوند، سمیت و عوارض جانبی ناشی از تجویزات کاهش داده می‌شوند. دستیابی به رسانش هدفمند دارو، با استفاده از پپتید‌ها، آنتی‌بادی ها، آپتامر یا مولکول‌های کوچک میسر می‌شود. روش‌های ذکر شده دوز میزان استفاده از داروی لازم را کاهش می‌دهند. بعلاوه، آنها دارو را به سمت بافت هدف هدایت می‌کنند. این مقاله مروری با هدف نشان دادن اهمیت ویژگی‌های نانوذرات متصل به آنتی‌بادی، مغناطیسی، کیتوسان مزدوج حساس به pH، در انتقال هدفمند دارو انجام شد. همچنین اثر انواع این نانوذرات بر رده‌های مختلف سلول‌های سرطانی، سمیت سلولی انواع نانوذرات و فارماکوکینتیک آنها مورد بررسی قرار گرفته است. روش گردآوری اطلاعات استفاده از پایگاه های علمی Scopus، Elsevier و PubMed می باشد.

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