Obesity is a major global health problem determined by genetic and environmental factors, and its incidence is increasing yearly. In recent years, dysbiosis of the gut microbiota has been shown to be closely linked to obesity. The purpose of this review was to investiga More
Obesity is a major global health problem determined by genetic and environmental factors, and its incidence is increasing yearly. In recent years, dysbiosis of the gut microbiota has been shown to be closely linked to obesity. The purpose of this review was to investigate the characteristics of gut microbiota in obesity, the mechanism of obesity caused by gut microbiota, and the effect of exercise and diet. For this purpose, Sid.ir and Magiran.Com databases as well as the system of scientific and research publications approved by the Ministry of Science in the field of sport sciences were searched for domestic articles from 1380 to 1401. The keywords used for searching were "obesity" or "diet" or "overweight" or "weight loss" and or "exercise training" combined with "gut microbiota". For foreign articles between 2000 and 20223, PubMed, Megapaper, and Google Scholar databases were used. The searched keywords were "obesity" or "diet" or "overweight" or "weight loss" and or "exercise training" combined with "gut microbiota". The results indicate that gut microbiota induce the occurrence and development of obesity by increasing host energy absorption, increasing central appetite, enhancing fat storage, contributing to chronic inflammation, and regulating circadian rhythms. Akkermansia muciniphylla abundance has also been shown to inversely correlate with obesity and related metabolic disorders. Our findings indicate that exercise training is another important factor in the relationship between the microbiota, host immunity and host metabolism, with diet playing an important role.,
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Hot spring extreme ecosystems are important biological resources for identifying the genetic stocks of thermophilic microorganisms and their biological characteristics in terms of tolerance and survival in high temperatures in order to use of their potential in various More
Hot spring extreme ecosystems are important biological resources for identifying the genetic stocks of thermophilic microorganisms and their biological characteristics in terms of tolerance and survival in high temperatures in order to use of their potential in various industries and biotechnology. Although there have been many studies on the microbiome of these biomass in recent years in the world, so far few studies have been done on such indigenous extreme environments of Iran. Iran has a variety of geothermal and volcanic areas which contained numerous unique springs with antimicrobial and antifungal, anti-rheumatism and other muscle aches properties. In this study, the identification of composition of different taxa of the bacterial community of Qeynarjeh hot spring as one of the hottest chloride springs in the world with the temperature of 86◦ C was performed by independent cultivation methods using next generation sequencing techniques. For quantitative profiling of the relevant bacterial community or so-called metagenomics analysis, 16s rRNA gene libraries were constructed from three functional regions of taxonomic classification V1 to V3 with barcoded primers. By bioinformatics analysis, 200 different taxa belonging to different bacterial families and genera were identified with MG-RAST and SILVAngs systems. The dominant taxa with the most abundant, are respectively: Pediococcus acidilactici، uncultured (unclassified) bacterium، Lactobacillus rhamnosus، Thermus scotoductus، Thermus sp. HR13 و Thermus sp. BXR.
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Background & Aim: Microbiota is a collection of microorganisms that live in the oral cavity, respiratory system and intestine of multicellular organisms. Microbiota exerts numerous physiological and pathological effects on the host in which it lives. Increasing attentio More
Background & Aim: Microbiota is a collection of microorganisms that live in the oral cavity, respiratory system and intestine of multicellular organisms. Microbiota exerts numerous physiological and pathological effects on the host in which it lives. Increasing attention has been directed to the interaction of host and microbiota. Adenomatous polyps are one of the common symptoms of colon cancer, the second leading cause of cancer-related death worldwide. Our study tries to show the relationship between Lactobacillus, Bifidobacterium, Enterococcus faecalis and Fusobacterium nucleatum in the intestinal paraffin tissue samples of adenomatous polyp patients and healthy individuals.
Materials & methods: In this study, in order to investigate the mentioned bacteria in a total of 100 samples of intestinal paraffin tissue from adenomatous polyp patients (50 people) and healthy controls (50 people) for the presence, copy number and relative quantity of the above bacterial species using Real-time polymerase chain reaction (PCR), compared to the reference gene, were investigated.
Results: In the studied samples, the presence and number of copies of Enterococcus faecalis bacteria in adenomatous polyp samples was significantly higher than the other three groups. There was no significant difference in the abundance and presence of Fusobacterium nucleatum and Lactobacillus species between the two groups. Also, a decrease in the average number of gaps and the relative abundance of Bifidobacterium species in adenomatous polyps compared to the control group was obtained.
Conclusion: Our study showed a higher number of Enterococcus faecalis bacteria and a decrease in the number of Bifidobacterium species in the samples of intestinal paraffin tissue of patients with adenomatous polyps compared to the control group. However, any association between gut microbiome dysbiosis and adenomatous polyps remains unknown.
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