Gut microbiota and obesity; Investigating the effectiveness of exercise training and diet

Subject Areas : Effect of Physical Activity on Diseases

fatemeh  islami ¹ (faculty member of Golestan university)

Received: 2023-04-17 Accepted : 2023-05-08 Published : 2023-05-22

Keywords: Obesity, microbiome, gut microbiota, Dysbiosis,

Abstract :

Obesity is a major global health problem determined by genetic and environmental factors, and its incidence is increasing yearly. In recent years, dysbiosis of the gut microbiota has been shown to be closely linked to obesity. The purpose of this review was to investigate the characteristics of gut microbiota in obesity, the mechanism of obesity caused by gut microbiota, and the effect of exercise and diet. For this purpose, Sid.ir and Magiran.Com databases as well as the system of scientific and research publications approved by the Ministry of Science in the field of sport sciences were searched for domestic articles from 1380 to 1401. The keywords used for searching were "obesity" or "diet" or "overweight" or "weight loss" and or "exercise training" combined with "gut microbiota". For foreign articles between 2000 and 20223, PubMed, Megapaper, and Google Scholar databases were used. The searched keywords were "obesity" or "diet" or "overweight" or "weight loss" and or "exercise training" combined with "gut microbiota". The results indicate that gut microbiota induce the occurrence and development of obesity by increasing host energy absorption, increasing central appetite, enhancing fat storage, contributing to chronic inflammation, and regulating circadian rhythms. Akkermansia muciniphylla abundance has also been shown to inversely correlate with obesity and related metabolic disorders. Our findings indicate that exercise training is another important factor in the relationship between the microbiota, host immunity and host metabolism, with diet playing an important role.,