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Open Access Article
1 - Studying the therapeutic effect of artemisinin along with endometrial stem cells containing TSP-1 gene on Alzheimer's disease in streptozotocin-induced Alzheimer's-diabetes model of rat
پروین Poorgholam پریچهره Yaghmaei مهدی Noureddini زهرا HajebrahimiAlzheimer's is the most common neurodegenerative disease of the elderly. Oxidative stress and inflammation play an important role in Alzheimer's disease. The risk of Alzheimer's disease is high in diabetic people, and insulin resistance occurs in the brain of Alzheimer' MoreAlzheimer's is the most common neurodegenerative disease of the elderly. Oxidative stress and inflammation play an important role in Alzheimer's disease. The risk of Alzheimer's disease is high in diabetic people, and insulin resistance occurs in the brain of Alzheimer's patients. Accumulation of amyloid plaques leads to angiogenesis and increased permeability of the vessels. Today, medicinal plants are receiving attention due to fewer side effects than chemical drugs. In the present study, the protective effect of Artemisia herbal product (artemisinin) along with endometrial stem cells containing the antiangiogenesis gene (thrombospondins-1 or TSP-1) was investigated in Alzheimer's disease induced by streptozotocin in a diabetic male rat laboratory model. 3 days after the induction of Alzheimer's and diabetes using streptozotocin, the animals received stem cells intranasally and then received artemisinin for one month (50 mg/kg). Initial and final weight, blood sugar, and interleukin-6 serum levels were measured, and brain amyloid plaques were examined by hematoxylin-eosin staining. The results showed that the induction of Alzheimer's and diabetes led to a significant decrease in body weight and an increase in blood sugar, interleukin-6, and brain amyloid plaques. Treatment with artemisinin and stem cells, separately and simultaneously, improved these parameters. The findings of this research showed that human endometrial stem cells that contain the TSP-1 gene can be used as a potential source of stem cells along with natural antioxidants artemisinin to reduce the symptoms of Alzheimer's disease. Manuscript profile -
Open Access Article
2 - A Comparison between Resting Levels of Interleukin-6, Tumor Necrosis Factor-Alpha, and Some Portions in the Immune System of Athletes and Non-Athletes with Spinal Cord Injury
Reza Shafiee soork Mohammad MashahdiThe purpose of the present study is to compare resting levels of Interleukin-6, Tumor Necrosis Factor-Alpha, and some portions in the immune system of athletes and non-athletes with spinal cord injury. Convenience sampling was used in this study and accordingly 10 non-a MoreThe purpose of the present study is to compare resting levels of Interleukin-6, Tumor Necrosis Factor-Alpha, and some portions in the immune system of athletes and non-athletes with spinal cord injury. Convenience sampling was used in this study and accordingly 10 non-athletes and 10 athletes from different fields were chosen. For testing the immune system, the number of white blood cells (lymphocytes, monocytes, and neutrophils), and for testing inflammatory indexes, resting levels of Interleukin-6 and Tumor Necrosis Factor-Alpha in the blood serum sample were measured. For measurement of blood parameters, ELSA method and the special kit were used. Descriptive statistics was used for data explanation/description and inferential statistics was used to explore the research results. Independent t-test was applied for the comparison between the research variables related to two athletic and non-athletic groups. The results revealed that there is no significant difference between athletes and non-athletes in Interleukin-6 (p=0.859), Tumor Necrosis Factor-Alpha (p=0.539), and the number of white blood cells (p=0.942). It seems that exercising is not considered as a threat for the immune system of those who have spinal cord injury although more research is needed to explore the effect of sport on the immune system of such patients. Manuscript profile -
Open Access Article
3 - Vitamin D3 Supplementation and Aquatic Exercise Combination as A Safe- Efficient Therapeutic Strategy to ameliorate Interleukin-6 and 10, and social interaction in Children with Autism
Fahimeh AdibSaber Soleyman Ansari Kolachahi Alireza Elmieh Akbar Allahyari Karnagh Babak Barkadehi -
Open Access Article
4 - The effect of four weeks of high-intensity interval training with different volumes on IL-6, TNF-α and hs-CRP in overweight and obese young girls.
rasoul dokhtabdiyan azizeh ahmadiThe purpose of this study is to compare the effect of four weeks of high-intensity interval training with different volumes on IL-6, TNF-α and hs-CRP in overweight and obese young girls. 24 girls (BMI>25 kg/m) were randomly placed in three groups: HIIT1 group ( MoreThe purpose of this study is to compare the effect of four weeks of high-intensity interval training with different volumes on IL-6, TNF-α and hs-CRP in overweight and obese young girls. 24 girls (BMI>25 kg/m) were randomly placed in three groups: HIIT1 group (n=8), HIIT2 group (n=8) and control group (n=8). HIIT1 group performed four sets of 30 seconds of running with an intensity of 19-20 RPE, two minutes of rest between sets in each session. HIIT2 group performed four sets of 60 seconds of running with the same intensity and four minutes of rest between sets. training was performed three sessions a week for four weeks. Blood samples were evaluated to measure serum levels of IL-6, TNF-α and hs-CRP 48 hours before and 48 hours after training. To analyze the data . Mixed analysis of variance (ANOVA) test was used at a significant level (P<0.05). hs-CRP level significantly increased only in the HIIT2 group (p<0.05). No significant difference was observed between the groups (p=0.377). The IL-6 significantly decreased only in the HIIT2 group (p<0.05). A significant difference was observed only between the HIIT2 group and the control group (p=0.031). The mean of TNF-α showed a significant decrease only in the HIIT2 group (p<0.05). a significant difference was observed between the HIIT2 group and the control group (p=0.042). It seems that medium-term HIIT training reduces inflammatory indicators (IL-6, TNF-α) compared to short-term and probably has a role in reducing the incidence of heart and metabolic diseases in these people. Manuscript profile -
Open Access Article
5 - The effect of fosfomycin, Saccharomyces bulardii and Saccharomyces cerevisiae on performance, antioxidant activity and expression of interleukin-6 gene in Holstein calves
saber sabooni Mohammad Chamani Ali Asghar Sadeghi Mehdi Amin-Afshar Nasser Emam Jomeh KashanThe aim of this study was to evaluate the effect of fosfomycin antibiotic as well as yeast probiotics of S. bulardii and S. cerevisiae on performance, antioxidant activity and expression of interleukin-6 gene in Holstein calves. In order to test, 20 newborn Holstein cal MoreThe aim of this study was to evaluate the effect of fosfomycin antibiotic as well as yeast probiotics of S. bulardii and S. cerevisiae on performance, antioxidant activity and expression of interleukin-6 gene in Holstein calves. In order to test, 20 newborn Holstein calves were distributed in 5 treatments and 4 replications (each replication including 1 calf) for 60 days after feeding with colostrum in a completely randomized design from the age of 3 days. Experimental treatment diets include 1: control (without antibiotics and probiotics), 2: fosfomycin (0.165 g/kg BW), 3: milk-soluble S. boulardii (1 g/kg BW), 4: milk-soluble S. cerevisiae (1 g/kg BW) and 5: A mixture of S. boulardii and S. cerevisiae were dissolved in milk (1 g/kg BW each). The amount of feed intake, weight gain and feed conversion ratio of none of the treatments were not significantly different from the control (P>0.05). The amount of serum glutathione peroxidase and superoxide dismutase enzymes as well as the amount of interleukin-6 gene expression in the whole period in calves that used a mixture of S. boulardii and S. cerevisiae had the highest significant difference with the control (P<0.05). In general, the use of a mixture of yeast probiotics had a greater effect on the antioxidant system and immune system of calves than their separate use and also compared to antibiotics in calves nutrition. Manuscript profile -
Open Access Article
6 - Comparing the effect of aerobic exercise in clean and polluted air on the responses of interleukin-6 and Reactive Protein-C in the active people
Naser Rabbani Farzaneh Taghian
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