Atherosclerosis is characterized by the accumulation of fat and inflammatory response in the artery intima and can cause narrowing or complete blockage of the artery. Thymol is a phenolic monoterpene with antioxidant and anti-inflammatory properties. The aim of this stu More
Atherosclerosis is characterized by the accumulation of fat and inflammatory response in the artery intima and can cause narrowing or complete blockage of the artery. Thymol is a phenolic monoterpene with antioxidant and anti-inflammatory properties. The aim of this study was to evaluate the effects of thymol on blood lipids, atherogenic indices and atheroma plaque of NMRI mice fed a high-cholesterol diet (HCD). 45 NMRI male mice were divided into 5 groups (n=9): Animals of the control group received a normal diet. Whiles in the HCD group received a diet containing 2% cholesterol for 18 weeks. Animals of the sham group received HCD for 12 weeks and then normal diet for 6 weeks with a thymol solvent (oil). The experimental groups 1 and 2 received HCD for 12 weeks and then received a normal diet with thymol at doses of 12 mg/kg and 24 mg/kg for 6 weeks, respectively. At the end of study, concentration of serum lipids and atherogenic indices were measured. Also aorta was measured microscopically. In the present study, consumption of HCD resulted in the formation of atheroma plaque, increased serum triglycerides, total cholesterol concentration, atherogenic indices and significantly decreased high density lipoprotein cholesterol (HDL-C). Treatment with both doses of thymol significantly reduced these changes and improves blood lipids, atherogenic indices was normal and atheroma plaques. The results of this study suggest that thymol can be used for treatment of increased total cholesterol and triglycerides and to improve the atheroma plaque.
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Cardiovascular disease is related with various risk factors. The most important of these are age. Coronary arterial disease mortality is increased after menopause. It is due to hypoestrogenemia. Soy bean is a source of fetoestrogen that is similar to hormone. The most i More
Cardiovascular disease is related with various risk factors. The most important of these are age. Coronary arterial disease mortality is increased after menopause. It is due to hypoestrogenemia. Soy bean is a source of fetoestrogen that is similar to hormone. The most important fetoestrogen is isoflavone. Soy bean is source of isoflavone that can decrease serum total cholesterol so protect of heart disease.In this randomized clinical trial 50 menopause women with hyper lipidemia and inclusion criteria were chosen. They were divided randomly to two groups (control and soya milk) diet. In soya milk group they were given 1 liter soya milk every day for 12 weeks. In control group they were not given soya milk or any product of soya. Initial and after 12weeks they were assayed for serum lipids profile. Data were collected and analyzed by SPSS software. There were no significant changes in serum lipids profile (triglyceride, HDL-cholesterol, LDL-cholesterol, total cholesterol) within control group Initial and after 12 weeks (P=NS). There were no significant changes in serum lipids profile) triglyceride, HDL-cholesterol, LDL-cholesterol, total cholesterol) within soya milk group Initial and after 12 weeks (P=NS). There were no significant changes in serum lipids profile) triglyceride, HDL-cholesterol, LDL-cholesterol, total cholesterol)between soya milk group and control group Initial and after 12weeks (P=NS).It seems soy milk has no actually effects on serum lipids profile, therefore this subject need to additional studies.
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Atherosclerosis is a chronic inflammatory disease of the artery that is mainly known by arterial wall thickening. The use of medicine herbs with minimal side effects in hypercholesterolemia treatment and removal of atherosclerotic plaque is important. The aim of the pre More
Atherosclerosis is a chronic inflammatory disease of the artery that is mainly known by arterial wall thickening. The use of medicine herbs with minimal side effects in hypercholesterolemia treatment and removal of atherosclerotic plaque is important. The aim of the present study was to investigate the comparative effect of simvastatin with methanolic extract and hyoscyamoside extracted from Hyoscyamus niger plant on APO A gene expression in Wistar atherosclerosis male rats.Forty Wistar male rats weighing approximately 180 gr (at the beginning of the experiment) were prepared and randomly divided into 5 groups including 8 (control, sham, experimental 1, 2 and 3). All groups (except control) received fatty foods (1% cholesterol) in addition to 2% cholesterol for 40 days (receiving saline water 1 mg/kg daily by control group during this period). Then, the three experimental groups were treated daily with 40 mg/kg of simvastatin, 25 mg/kg of hyoscyamoside and 25 mg/kg of methanolic extract of Hyoscyamus niger plant for 28 days, respectively. During the treatment, sham group received 1 mg/kg saline water daily. Finally, APO A gene expression was determined by blood sampling with real-time PCR tecnique in leukocytes. Also, serum lipid levels were measured by photometric method. Methanolic extract and Hyoscyamus niger plant extracted-hyoscyamoside and simvastatin were caused a significant increase in APO A gene expression in all three experimental groups compared to sham group. Also, methanolic extract was more effective than other products in increasing this gene expression. Methanolic extract of Hyoscyamus niger plant and extracted hyoscyamoside have an additive effect on APO A gene expression and increase serum HDL levels.
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