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Open Access Article
1 - Association Between Dietary Atherogenic Index and Risk of Polycystic Ovary Syndrome: A Case-Control Study in Tehranian Women
Parisa Navidgouei Behnood Abbasi Sedigheh HosseiniPolycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder characterized by impaired glucose metabolism and insulin resistance. Dietary fatty acids may play a role in the progression of PCOS and related metabolic abnormalities. We conducted a case-control st MorePolycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder characterized by impaired glucose metabolism and insulin resistance. Dietary fatty acids may play a role in the progression of PCOS and related metabolic abnormalities. We conducted a case-control study to examine the association between dietary atherogenic index (AI) and PCOS risk. The study included 203 women with PCOS and 291 healthy controls from Taleghenai Hospital in Tehran, Iran. Demographic, anthropometric, and dietary data were collected using a validated food frequency questionnaire. AI was calculated based on dietary fatty acid intake. Participants’ mean ages were 28.98±5.43 and 30.15±6.21 years for cases and controls, respectively. No significant differences in intakes of total fat, cholesterol, saturated, trans, monounsaturated fatty acids, linoleic, or linolenic acids were observed across AI quartiles (p>0.05). However, polyunsaturated fatty acid intake decreased significantly with increasing AI quartiles (p=0.034). In addition, this case-control study found no relationship between the dietary atherogenic index and the risk of PCOS among Iranian women. Further research is needed to validate these findings and elucidate the role of dietary fatty acids in PCOS pathogenesis. Manuscript profile -
Open Access Article
2 - Survey relationship between rs2303169 polymorphism in FBN3 gene in patients with polycystic ovary syndrome
Reyhaneh Kalhor naser kalhor Hourieh Kalhor Mojtaba SohrabiAbstract Introduction: Polycystic ovary syndrome (PCOS) is a very complex and heterogeneous disorder that genetic and environmental factors have a significant contribution to its creation. PCOS is the commonest endocrine abnormality in 6 to 10 percent of women in fertil MoreAbstract Introduction: Polycystic ovary syndrome (PCOS) is a very complex and heterogeneous disorder that genetic and environmental factors have a significant contribution to its creation. PCOS is the commonest endocrine abnormality in 6 to 10 percent of women in fertility age that FBN3 gene is one of the most important candidate genes, for PCOS. This gene has 20 polymorphisms. This study examines the relationship between rs2303169 polymorphism in FBN3 gene in women with PCOS. Method: This study is a case-control study which is done on 100 women with PCOS and 100 healthy women. In this research, Tetra-ARMS PCR method was used to study the relationship between rs2390169 genotypes in FBN3 gene and the probability of getting PCOS in both patient and control groups. Connecting data from this study are analyzed statistically using SPSS software, chi-squared tests and Independent student t-test. Results: The results of the research showed no significant relationship between rs2303169 polymorphism in FBN3 gene and PCOS (P = 0.152). Also, CT and TT genotypes increased the probability of getting PCOS to 1,995 and 1,621 times towards CC genotype respectively. Conclusion: For the first time, this study showed that there is no significant relationship between rs2303169 polymorphism in FBN3 gene and PCOS. However, relationship between polymorphisms of other genotypes in FBN3 gene and PCOS needs a wider research in greater populations and different ethnicities in the country. Key words: Polycystic ovary syndrome; Polymorphism; FBN3 gene. Manuscript profile -
Open Access Article
3 - The effect of selenium nanoparticles on DNA oxidative damage, oxidative stress parameters and ovarian tissue structure in an animal model of polycystic ovary syndrome
Mohammad Amin Edalatmanesh Samaneh RafieiPolycystic ovary syndrome (PCOS) is associated with hormonal-metabolic disorders, oxidative stress and ovulation disorders. The present study evaluated the effect of selenium nanoparticles (SeNPs) on the activity of antioxidant enzymes and ovarian tissue structure and o MorePolycystic ovary syndrome (PCOS) is associated with hormonal-metabolic disorders, oxidative stress and ovulation disorders. The present study evaluated the effect of selenium nanoparticles (SeNPs) on the activity of antioxidant enzymes and ovarian tissue structure and oxidative DNA damage in the polycystic ovary syndrome (PCOS) model. 32 female Wistar rats were divided into 4 control groups, PCOS, PCOS+SeNPs0.1 and PCOS+SeNPs0.1. Polycystic ovary syndrome was induced by a single intramuscular injection of estradiol valerate (4 mg/kg) and SeNPs with doses of 0.1 and 0.2 mg/kg were administered orally for 14 days. At the end, the tissue level of superoxide dismutase (SOD), catalase (CAT) enzymes, content of malondialdehyde (MDA) and 8-hydroxydeoxyguanosine (8-OHdG) in the ovarian tissue was measured by ELISA technique and the ovarian tissue structure was examined histopathologically. A significant decrease in the number of follicular cysts, 8-OHdG and MDA levels along with a significant increase in tissue levels of SOD and CAT enzymes were seen in the SeNPs treatment groups compared to the PCOS group. In fact, SeNPs with antioxidant function improved ovarian tissue structure in polycystic ovary syndrome model. Manuscript profile -
Open Access Article
4 - Effect of berberine on polycyctic ovary syndrome induced by letrozole in adult female Wistar rats
Saba Safdarpour Akram Eidi Pejman MortazaviBerberine which is the major active component of Berberis vulgaris, has been widely used in traditional medicine and has an antioxidant activity against oxidative stress. Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in reproductive-aged MoreBerberine which is the major active component of Berberis vulgaris, has been widely used in traditional medicine and has an antioxidant activity against oxidative stress. Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in reproductive-aged women. PCOS is often associated with a metabolic syndrome. In the present study, the effect of berberine on letrozole-induced PCOS was investigated in adult female Wistar rats. The rats were randomly divided into 8 groups: normal control, berberine (25, 50 and 100 mg/kg intragastrically, daily) alone, PCOS control rats (letrozole, 1 mg/kg, intragastrically, daily), berberine (25, 50 and 100 mg/kg intragastrically, daily) together with (letrozole 1 mg/kg, intragastrically, daily), and treatment was performed accordingly. Administration of berberine was started 30 minutes before the first dose of letrozole and continued up to 28 days. The animals were euthanized 24 hours after the last dose of the treatment. Antioxidant activity was tested by measuring the activity of superoxide dismutase, catalase and glutathione peroxidase enzymes as well as the amount of malondialdehyde in ovarian tissue homogenates. The findings of the present study showed that berberine increases antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase and decreases malondialdehyde levels. The results of this study suggest that berberine treatment may be beneficial in letrozole-induced PCOS in rats. Manuscript profile -
Open Access Article
5 - Effect of green tea extract (Camellia sinensis) on polycystic ovary syndrome induced by letrozole in adult female Wistar rats
Seyed Iman Khodarahmi Pejman Mortazavi Akram EidiGreen tea (Camellia sinensis), has always been a focus of interest in traditional medicine for its biochemical and medicinal properties as an antioxidant agent. Polycystic ovary syndrome (PCOS) is a common endocrinopathy among women of reproductive age. In the present s MoreGreen tea (Camellia sinensis), has always been a focus of interest in traditional medicine for its biochemical and medicinal properties as an antioxidant agent. Polycystic ovary syndrome (PCOS) is a common endocrinopathy among women of reproductive age. In the present study, the effects of green tea extract on letrozole-induced PCOS were evaluated. Forty eight adult female Wistar rats were assigned to eight groups in random: healthy control group (no treatment), PCOS control group (letrozole at 1 mg/kg by gavage), three healthy experimental groups (green tea extract at 50, 100 and 200 mg/kg body weight by gavage), and three experimental PCOS groups (green tea extract at 50, 100 and 200 mg/kg body weight + letrozole at 1 mg/kg by gavage). On the 28th day (at the end of the experiment), the rats were euthanized, and the antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) and lipid peroxidation were assessed in the ovarian tissue homogenates. The results indicated that the green tea extract significantly increased the activities of the antioxidant enzymes and decreased lipid peroxidation (p<0.001). Our results showed that the green tea extract was also effective in treating letrozole-induced PCOS in the rats by increasing the activities of the antioxidant enzymes. Manuscript profile -
Open Access Article
6 - اثرات دارچین بر سندرم تخمدان پلی کیستیک
مهرداد استادپور مجید غلامی آهنگران سیدحسین حیدریBackground & Aim: Polycystic ovary syndrome (PCOS) is a major endocrine disorder in young age women affecting their health-related quality of life (HRQOL) and their mental well-being as well. In this review, the authors discuss the effect of cinnamon as an herbal me MoreBackground & Aim: Polycystic ovary syndrome (PCOS) is a major endocrine disorder in young age women affecting their health-related quality of life (HRQOL) and their mental well-being as well. In this review, the authors discuss the effect of cinnamon as an herbal medicine on PCOS in humans and introduce the advantages and efficacy of these herbs on the control of this problem.Experimental: In this review, the authors searched the main related keywords e.g. polycystic, and cinnamon in main biological data centers e.g. Science Direct, Pubmed and Google Scholar. Then, the authors classified articles and only discussed the valid full papers in different categories.Results: The study of papers related to the effect of cinnamon on polycystic ovary syndrome revealed that this herb can control this problem via some route e.g., by control of triglyceride and cholesterol to diminish risk factors of fat deposition and by inhibitory effects on oxidative cascade decreasing the cystic formation process.Recommended applications/industries: The review proposed the positive effect of cinnamon on the control of PCOS in humans. Therefore, supplementary cinnamon on feed can diminish PCOS via some metabolic cycle. Manuscript profile -
Open Access Article
7 - A review of common animal models in reproductive biology studies
ramazan khanbabaee nahideh nazdikbin yamchiOne of the major problems in today's world is the inability to have children. This has affected social health and led researchers to preclinical studies. Over several decades, numerous animal models in the biology of reproduction have entered the field of research. Diff MoreOne of the major problems in today's world is the inability to have children. This has affected social health and led researchers to preclinical studies. Over several decades, numerous animal models in the biology of reproduction have entered the field of research. Different mechanisms and approaches induce different types of reproductive diseases. Variety in conventional methods in inducing animal models has confused researchers. Since premature ovarian failure, azoospermia and polycystic ovary syndrome are important causes of inability of couples to have children, we decided to review the studies conducted in this field, appropriate laboratory methods and processes to create an animal model for premature failure. Introduce ovarian, azoospermia and polycystic ovary syndrome. The use of chemical drugs used in adults as chemotherapy drugs, especially cyclophosphamide, is known as the most appropriate method to create an animal model in premature ovarian failure. To create an animal model of azoospermia, busulfan injection is used as the most common method to induce azoospermia. Finally, to create an animal model of polycystic ovary syndrome, the most common method is to inject androgens into dihydroepiandestrone. In the present study, common methods along with the relevant protocols, along with the advantages and disadvantages of each model are presented. Manuscript profile -
Open Access Article
8 - Using stem cells as a new approach for treatment of polycystic ovary syndrome
somayeh ebrahimi-barough fatemeh kouchakzadeh seyyed mahdi kalantar jafar Ai behrooz aflatoonianPolycystic ovary syndrome (PCOS) is a common disorder in women that usually occurs in reproductive age in a number of people around the world. Symptoms include impaired folliculogenesis, hyperandrogenism, menstrual irregularities, numerous small cystic follicles, infert MorePolycystic ovary syndrome (PCOS) is a common disorder in women that usually occurs in reproductive age in a number of people around the world. Symptoms include impaired folliculogenesis, hyperandrogenism, menstrual irregularities, numerous small cystic follicles, infertility, and chronic anovulation. The present review study was conducted with the aim of describing the use of stem cells for the treatment of PCOS, their biological characteristics and mechanism of action. The information related to this review study was collected from 53 papers that searched from databases such as SID, Magiran, PubMed, Google Scholar, Ironed Scopus and clinicaltrials. Currently, only the studies are at the level of pre-clinical studies on bone marrow mesenchymal stem cells, adipose stem cells, cord blood stem cells and exosomes derived mesenchymal stem cells, and there are only two studies on the Clinicaltrials.gov website as clinical studies. Due to the uncertainty of the safety of this method for the purpose of using stem cells in human, more studies in this field should be designed and implemented. Manuscript profile -
Open Access Article
9 - A comparative study of the therapeutic effects of mesenchymal stem cells on polycystic ovary syndrome in various animal models
Umeh Leila Bakhshi Seyed Gholam Ali Jorsaraei Ramzan Khanbabaeia Maryam Gholamitabar tabari Seyedeh Zahra BabazadehInfertility is a global health problem. One of the main causes of infertility in women is polycystic ovary syndrome (PCOS). Different methods are used to treat such people. Using stem cells and its products can be a good alternative for its treatment. There are differen MoreInfertility is a global health problem. One of the main causes of infertility in women is polycystic ovary syndrome (PCOS). Different methods are used to treat such people. Using stem cells and its products can be a good alternative for its treatment. There are different models for inducing PCOS in animal models. Mesenchymal stem cells reduce ovarian dysfunction in PCOS mice. Tail injection of BM-MSC will improve the process of folliculogenesis. Intraovarian injection of BM-Hmsc and UC-MSC mesenchymal stem cells improves the process of folliculogenesis. AMSCs mesenchymal stem cell injection is associated with a positive result in fertility. MSC-EV stem cells improve fertility and increase folliculogenesis. One of the main causes of infertility in women is polycystic ovary syndrome (PCOS). The use of cell therapy for various diseases including PCOS is considered. The use of MSC in the treatment of infertility is in its preclinical research stages. The safety and efficacy of MSCs in the treatment of infertility needs further investigation. In this study, we have compared the therapeutic effects of mesenchymal stem cells on polycystic ovary syndrome in various animal models. Manuscript profile -
Open Access Article
10 - Role of Oxidized Low-density Lipoprotein in Human Diseases: A Review
Israa Qusay Falih Mohammed A.H. Alobeady Shaima Rabeea Banoon Mohanad Yakdhan Saleh -
Open Access Article
11 - The Interaction of Gallic Acid and Swimming Training on Ovarian Histology in Rats with Polycystic Ovary Syndrome
Maryam Ebrahimi Narges Abarshahr Mohammad Amin EdalatmaneshPolycystic Ovary Syndrome (PCOS) is the leading cause of infertility due to lack of ovulation and the result of oxidative stress of ovarian tissue, which is associated with disability in ovarian functions. This study aims at evaluating the effect of 4 weeks of Gallic Ac MorePolycystic Ovary Syndrome (PCOS) is the leading cause of infertility due to lack of ovulation and the result of oxidative stress of ovarian tissue, which is associated with disability in ovarian functions. This study aims at evaluating the effect of 4 weeks of Gallic Acid (GA) prescription and swimming (EX) training on ovarian tissue parameters in PCOS model. Forty adult Wistar female rats weighing 180 ± 10 g were randomly divided into 5 groups: PCOS, PCOS + GA, PCOS + EX and PCOS + GA + EX. To induce the PCOS model, letrozole (1 mg / kg) was NG tubed for 28 days. Then, GA was prescribed orally for 4 weeks and swimming was performed for 4 weeks and 3 sessions per week. Finally, after dissection of the ovary and staining with hematoxylin-eosin, histological evaluations were performed. The results showed a significant decrease in corpus luteum diameter, number of monolayer, multilayer, secondary and Graafian follicles and corpus luteum in PCOS group and also a significant increase in the number of atretic and cystic follicles compared with control group. While the interaction of GA prescription and swimming improved ovarian parameters. However, no significant change in the diameter of oocytes and primary and multilayered follicles was observed in the groups. GA and swimming appear to be effective on restoring the folliculogenesis of PCOS rat model and the ovulation process. Manuscript profile -
Open Access Article
12 - The Effect of Thymol on Rat with Polycystic Ovary Syndrome
Sara Hojat jalali Parichehre Yaghmaee Azadeh Ebrahim-Habibi Nasim Hayati rodbariPolycystic ovary syndrome (PCOS) is one of the most common endocrinopathy disorders in women and is one of the most important factors that lead to infertility. Thymol has many antimicrobial and antifungal effects. The aim of this study is to investigate the effect of th MorePolycystic ovary syndrome (PCOS) is one of the most common endocrinopathy disorders in women and is one of the most important factors that lead to infertility. Thymol has many antimicrobial and antifungal effects. The aim of this study is to investigate the effect of thymol in the treatment of rats suffering from polycystic ovary syndrome (PCOS). This experimental study was conducted on female Wistar rats and the animals were divided into three groups: control, control (sham), and experimental. In order to induce PCOS, estradiol-valerate in the amount of 40 mg/4 ml was injected intramuscularly in 2 control and experimental groups for 25 days. Then, for 4 weeks, the control group and the experimental group were given grape seed oil, thymol in the amount of received 12 mg/kg in the amount of 1 cc through gavage. Finally, the animals were anesthetized by ether, the ovaries were removed for histological examination, and the blood serum was separated to examine the blood parameters. The findings of this study indicate that in the group The recipient of thymol increased the number of primary follicles (p < 0.01), developing and corpus luteum (p < 0.05), grafts (p < 0.001) and reduced cysts (p < 0.001) compared to the group. A control was observed. In the examination of blood parameters, it was found that in the group receiving thymol, there was a decrease in LH hormone (p < 0.01) and an increase in FSH hormone (p < 0.01). It was observed with the control group. The results of the research showed that probably the composition of thymol can be effective in the treatment of patients with polycystic ovary syndrome, although this case requires more studies. Manuscript profile -
Open Access Article
13 - Effect of Stem Cells Containing TSP-1 Gene along with Letrazole on ROS and VEGF Levels in Polycystic Ovary Syndrome Induced by Estradiol Valproate in Female Wistar Rat Model
masoumeh Rahimi maryam bananaj Ramin Hajikhani maryam akhavantaheriPolycystic ovary syndrome (PCOS) is a complex genetic, endocrine and metabolic heterogeneous disorder and the most common endocrine disease and metabolic disorder in children of reproductive age and the most important cause of infertility due to ovulation in women. Ther MorePolycystic ovary syndrome (PCOS) is a complex genetic, endocrine and metabolic heterogeneous disorder and the most common endocrine disease and metabolic disorder in children of reproductive age and the most important cause of infertility due to ovulation in women. There is a direct and close relationship between systemic and local inflammation and the rate of angiogenesis and PCOS. Stem TSP-1 and mice receiving letrazole and mice receiving concomitant TSP-stem cells and letrazazole were categorized and VEGF was measured by Real Time PCR and ROS by ELISA. Wistar female rats with polycystic ovary syndrome (PCOS) had a significant increase in VEGF gene expression and tissue ROS levels compared to the control group, which was significant. The results showed a significant decrease in VEGF gene expression and ROS levels compared with PCOS mice. The highest reduction was observed in letrrazole-receiving mice with TSP-1-containing stem cells compared to the other two treatments in both VEGF and ROS. ROS and VEGF levels are associated with increased ovarian masses, and increased ovarian masses with hypoxia, androgens, insulin, and AMH may increase VEGF levels. Manuscript profile
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