The Effect of Aerobic-Resistance Training on Anti-Mullerian Hormone Levels, Physical Fitness, Body Composition and Ultrasonographic Findings in Women with Polycystic Ovary Syndrome
Subject Areas : Journal of Physical Activity and HormonesMohammad Hedayati 1 , sanam Zahrani 2 , Mahtab Dehghanzade Sahi 3
1 -
2 -
3 - MSN, 17th Shahrivar Hospital, Guilan University of Medical Science, Rasht
Keywords: Polycystic Ovary Syndrome, Anti-Mullerian Hormone, Aerobic-Resistance Training, Physical Fitness, Body Composition,
Abstract :
Introduction: Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder affecting 5-8% of women of reproductive age, often leading to infertility, metabolic disorders, and increased androgen levels. This study investigates the effect of an eight-week aerobic-resistance training exercise training on Anti-Mullerian Hormone (AMH) levels, physical fitness, body composition, and ultrasonographic findings in women with PCOS.
Material & Methods: A quasi-experimental design was implemented with 25 women randomly assigned to either an experimental group (EG, N=13) or a control group (CG, N=12). EG participated in eight-week aerobic resistance training, while the control group maintained regular activity. Pre- and post-intervention measurements were taken for plasma AMH levels, body composition, physical fitness, and ultrasonographic evaluations of ovarian cysts.
Results: This study showed a significant decrease in body weight, body mass index (BMI), and AMH levels, on the other hand, the result showed that improvement in aerobic and anaerobic power in the EG compared to the CG (P<0.05), while no significant reduction in ovarian cyst size was observed.
Conclusion: These findings suggest that aerobic-resistance training may contribute to better management of body composition and hormonal levels in women with PCOS, enhancing their overall fitness and potentially improving reproductive outcomes. The study emphasizes the importance of non-pharmacological interventions, such as structured exercise programs, in managing the complex metabolic and reproductive challenges associated with PCOS. Further research is needed to explore the long-term effects of such interventions on ovarian function and fertility outcomes.
[1] Lőrincz CE, Börzsei D, Hoffmann A, Varga C, Szabó R. Mechanisms and Target Parameters in Relation to Polycystic Ovary Syndrome and Physical Exercise: Focus on the Master Triad of Hormonal Changes, Oxidative Stress, and Inflammation. Biomedicines. 2024;12(3):560.
[2] Azziz R. Polycystic ovary syndrome. Obstetrics & Gynecology. 2018;132(2):321-36.
[3] Teede HJ, Tay CT, Laven JJ, Dokras A, Moran LJ, Piltonen TT, et al. Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome. European journal of endocrinology. 2023;189(2):G43-G64.
[4] Turan V, Mutlu EK, Solmaz U, Ekin A, Tosun O, Tosun G, et al. Benefits of short-term structured exercise in non-overweight women with polycystic ovary syndrome: a prospective randomized controlled study. Journal of physical therapy science. 2015;27(7):2293-7.
[5] Benham JL, Booth JE, Friedenreich CM, Rabi DM, Sigal RJ. Comparative success of recruitment strategies for an exercise intervention trial among women with polycystic ovary syndrome: observational study. Journal of Medical Internet Research. 2021;23(3):e25208.
[6] Rebecca Block C, Blokland AA, Van Der Werff C, Van Os R, Nieuwbeerta P. Long-term patterns of offending in women. Feminist criminology. 2010;5(1):73-107.
[7] Mohammad MB, Seghinsara AM. Polycystic ovary syndrome (PCOS), diagnostic criteria, and AMH. Asian Pacific journal of cancer prevention: APJCP. 2017;18(1):17.
[8] Ollila M-M, Arffman RK, Korhonen E, Morin-Papunen L, Franks S, Junttila J, et al. Women with PCOS have an increased risk for cardiovascular disease regardless of diagnostic criteria—a prospective population-based cohort study. European Journal of Endocrinology. 2023;189(1):96-105.
[9] Wang H, Cao H, Cao J, Zhang L. [Retracted] The Visceral Adiposity Index (VAI) and Lipid Accumulation Product (LAP) Are Predictors of Insulin Resistance and Hyperandrogenaemia in Obesity/Overweight Women with Polycystic Ovary Syndrome. BioMed Research International. 2023;2023(1):1508675.
[10] Dos Santos IK, Ashe MC, Cobucci RN, Soares GM, de Oliveira Maranhão TM, Dantas PMS. The effect of exercise as an intervention for women with polycystic ovary syndrome: A systematic review and meta-analysis. Medicine. 2020;99(16):e19644.
[11] Kyu HH, Bachman VF, Alexander LT, Mumford JE, Afshin A, Estep K, et al. Physical activity and risk of breast cancer, colon cancer, diabetes, ischemic heart disease, and ischemic stroke events: systematic review and dose-response meta-analysis for the Global Burden of Disease Study 2013. bmj. 2016;354.
[12] Mul JD, Stanford KI, Hirshman MF, Goodyear LJ. Exercise and Regulation of Carbohydrate Metabolism. Progress in molecular biology and translational science. 2015;135:17-37.
[13] Butt MS, Saleem J, Zakar R, Aiman S, Khan MZ, Fischer F. Benefits of physical activity on reproductive health functions among polycystic ovarian syndrome women: a systematic review. BMC Public Health. 2023;23(1):882.
[14] Krystock A. Role of lifestyle and diet in the management of polycystic ovarian syndrome. Polycystic ovary syndrome: current and emerging concepts: Springer; 2013. p. 147-64.
[15] Hutchison SK, Stepto NK, Harrison CL, Moran LJ, Strauss BJ, Teede HJ. Effects of exercise on insulin resistance and body composition in overweight and obese women with and without polycystic ovary syndrome. The Journal of Clinical Endocrinology & Metabolism. 2011;96(1):E48-E56.
[16] Norman RJ, Noakes M, Wu R, Davies MJ, Moran L, Wang JX. Improving reproductive performance in overweight/obese women with effective weight management. Human reproduction update. 2004;10(3):267-80.
[17] Benham JL, Booth JE, Corenblum B, Doucette S, Friedenreich CM, Rabi DM, et al. Exercise training and reproductive outcomes in women with polycystic ovary syndrome: A pilot randomized controlled trial. Clinical endocrinology. 2021;95(2):332-43.
[18] Saha S, Saha S. Comparison of the effect of dietary and herbal supplements on anthropometric, metabolic and androgenic profiles of women with polycystic ovary syndrome: a systematic review and network meta-analysis protocol. Journal of the Turkish German Gynecological Association. 2023;24(4):277.
[19] Nybacka Å, Carlström K, Fabri F, Hellström PM, Hirschberg AL. Serum antimüllerian hormone in response to dietary management and/or physical exercise in overweight/obese women with polycystic ovary syndrome: secondary analysis of a randomized controlled trial. Fertility and sterility. 2013;100(4):1096-102.
[20] Seo D-C, Sa J. A meta-analysis of psycho-behavioral obesity interventions among US multiethnic and minority adults. Preventive medicine. 2008;47(6):573-82.
[21] Jiskoot G, Benneheij SH, Beerthuizen A, de Niet JE, de Klerk C, Timman R, et al. A three-component cognitive behavioural lifestyle program for preconceptional weight-loss in women with polycystic ovary syndrome (PCOS): a protocol for a randomized controlled trial. Reproductive health. 2017;14(1):34.
[22] Moran L. H utchison SK, Norman RJ, et al. Lifestyle changes in women with polycystic ovary syndrome. Cochrane Database Syst Rev. 2011;7.
[23] Shaw KA, O'Rourke P, Del Mar C, Kenardy J. Psychological interventions for overweight or obesity. Cochrane database of systematic reviews. 2005(2).
[24] Nasiri M, Monazzami A, Alavimilani S, Asemi Z. The Effect of High Intensity Intermittent and Combined (Resistant and Endurance) Trainings on Some Anthropometric Indices and Aerobic Performance in Women with Polycystic Ovary Syndrome: A Randomized Controlled Clinical Trial Study. International journal of fertility & sterility. 2022;16(4):268-74.
[25] Thomson R, Buckley J, Moran L, Noakes M, Clifton P, Norman R, et al. Comparison of aerobic exercise capacity and muscle strength in overweight women with and without polycystic ovary syndrome. BJOG: An International Journal of Obstetrics & Gynaecology. 2009;116(9):1242-50.
[26] Patten RK, Boyle RA, Moholdt T, Kiel I, Hopkins WG, Harrison CL, et al. Exercise interventions in polycystic ovary syndrome: a systematic review and meta-analysis. Frontiers in physiology. 2020;11:606.
[27] Orio Jr F, Giallauria F, Palomba S, Cascella T, Manguso F, Vuolo L, et al. Cardiopulmonary impairment in young women with polycystic ovary syndrome. The Journal of Clinical Endocrinology & Metabolism. 2006;91(8):2967-71.