List of Articles Pimozide

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  1 - Effects of Pimozide on Physiology of Reproduction in Adult Male Rat
  Tahereh Bagheri Mehrdad Shariati
  Inroduction & Objective: Pimozide is an antipsychotic with neuroleptic properties that has been found to be useful in the management of chronic schizophrenic patients , mania and hypomania. This drug blocks dopamine receptors. In this research the effect of pimozide wer More

  Inroduction & Objective: Pimozide is an antipsychotic with neuroleptic properties that has been found to be useful in the management of chronic schizophrenic patients , mania and hypomania. This drug blocks dopamine receptors. In this research the effect of pimozide were studied on pituitary gonad axis function, the concentration of testosterone , FSH and LH level and testis histological changes. Materials and Methods:The present study was done on 50 male rats wistar strain that divided to 5 groups of 10 animal, including: Control, sham (received normal saline as a solvent) and three pimozide (1,2,4 mg/ kg) received the experimental groups. The drug were administered for 30 days orally and blood samples were taken from the rats and serum concentrations of testosterone, FSH and LH were measured by RIA method. Histological changes were studied among experimental, control and sham groups. The results were evaluated by using SPSS software and ANOVA tests. Results:The results showed that 4 mg/ kg dose of pimozide reduced testosterone. The level of FSH and LH were increased (P ConclusionSo in general we can say that high doses of pimozide decreases the concentration of testosterone level and the number of spermatogenic cells exception sertoli. Manuscript profile
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  2 - The Performance Review Prebiotic Safety Isomalto-Oligosaccharide on Reducing the Incidence of Intestinal Tissue of Common Carp (Cyprinus Carpio) in the Face of Lethal Poison Concentration of Butachlor (Machty)
  Mohammad Forouhar Vajargah ّFatemeh Darabitabar Seyyed Ali Akbar Hedayati
  Inroduction & Objective: Pimozide is an antipsychotic with neuroleptic properties that has been found to be useful in the management of chronic schizophrenic patients , mania and hypomania. This drug blocks dopamine receptors. In this research the effect of pimo More

  Inroduction & Objective: Pimozide is an antipsychotic with neuroleptic properties that has been found to be useful in the management of chronic schizophrenic patients , mania and hypomania. This drug blocks dopamine receptors. In this research the effect of pimozide were studied on pituitary gonad axis function, the concentration of testosterone , FSH and LH level and testis histological changes. Materials and Methods: The present study was done on 50 male rats wistar strain that divided to 5 groups of 10 animal, including: Control, sham (received normal saline as a solvent) and three pimozide (1,2,4 mg/ kg) received the experimental groups. The drug were administered for 30 days orally and blood samples were taken from the rats and serum concentrations of testosterone, FSH and LH were measured by RIA method. Histological changes were studied among experimental, control and sham groups. The results were evaluated by using SPSS software and ANOVA tests. Results: The results showed that 4 mg/ kg dose of pimozide reduced testosterone. The level of FSH and LH were increased (P Manuscript profile
• Open Access Article
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  3 - The effect of LHRH-A2 alone and in combination with pimozide on induction of final maturation in Three-spot gourami (Trichogaster tricopterus)
  T. Naji H. Hosseinzadeh sahafi G. Shakibaian M. K. Jazebizadeh Sh. Ejtemaei Mehr
  The effect of LHRH-A2 alone and combined with dopamine antagonist (pimozide) on induction of final maturation were investigated in Three-spot gourami. Therefore, 80 female fish were evaluated in 8 treatments. The fishes in different groups were treated with LHRH-A2 (2, More

  The effect of LHRH-A2 alone and combined with dopamine antagonist (pimozide) on induction of final maturation were investigated in Three-spot gourami. Therefore, 80 female fish were evaluated in 8 treatments. The fishes in different groups were treated with LHRH-A2 (2, 8 µg per fish), pimozide (50µg per fish) and the combination of LHRH-A2 (2, 8 µg per fish) and pimozide(50µg per fish), there were 3 groups as control. Controls received the mixture of DMSO/PG (1:9) and FIA/Saline (1:1). One group also was  inject. 7 days after injection the mean of gonadosomatic index percentage and histological structures of ovary were compared with control groups.   Statistical analyses showed that the results of second (GSI%: 4/477) and fifth (GSI%: 5/027) Treatments in comparison with control group (GSI%: 2/92) were significant (P<0.05). This result was approved by histological study. Histological results showed that fifth treatment was more effective on induction of final maturation in Three-spot gourami. Manuscript profile