The Performance Review Prebiotic Safety Isomalto-Oligosaccharide on Reducing the Incidence of Intestinal Tissue of Common Carp (Cyprinus Carpio) in the Face of Lethal Poison Concentration of Butachlor (Machty)
Subject Areas :
Mohammad
Forouhar Vajargah
1
(کارشناسی ارشد شیلات، دانشکده شیلات و محیط زیست، دانشگاه کشاورزی و منابع طبیعی گرگان، گرگان. ایران)
ّFatemeh
Darabitabar
2
(کارشناسی ارشد شیلات، دانشکده شیلات و محیط زیست، دانشگاه کشاورزی و منابع طبیعی گرگان، گرگان. ایران)
Seyyed Ali Akbar
Hedayati
3
(استادیار گروه شیلات، دانشکده شیلات و محیط زیست، دانشگاه کشاورزی و منابع طبیعی گرگان، گرگان. ایران)
Keywords: Gonadotropin, Pimozide, Testosterone, Rat, Spermatogenesis,
Abstract :
Inroduction & Objective: Pimozide is an antipsychotic with neuroleptic properties that has been found to be useful in the management of chronic schizophrenic patients , mania and hypomania. This drug blocks dopamine receptors. In this research the effect of pimozide were studied on pituitary gonad axis function, the concentration of testosterone , FSH and LH level and testis histological changes. Materials and Methods: The present study was done on 50 male rats wistar strain that divided to 5 groups of 10 animal, including: Control, sham (received normal saline as a solvent) and three pimozide (1,2,4 mg/ kg) received the experimental groups. The drug were administered for 30 days orally and blood samples were taken from the rats and serum concentrations of testosterone, FSH and LH were measured by RIA method. Histological changes were studied among experimental, control and sham groups. The results were evaluated by using SPSS software and ANOVA tests. Results: The results showed that 4 mg/ kg dose of pimozide reduced testosterone. The level of FSH and LH were increased (P
