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Open Access Article

1 - Theoretical Study of Flavopiridol Binded to Transition Metals
M. Monajjemi1 H. Passdar L. Saedi R. Ghiasi F. Mollaamin

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Open Access Article

2 - Study of the effect of nerolidol on Alzheimer's disease in Wistar rats
پیمان Taheri پریچهره Yaghmaei زهرا Hajebrahimi کاظم Parivar

10.30495/jcp.2022.20567

Alzheimer's disease is the most important cause of dementia in human societies and the elderly population. One of the most important symptoms of this disease is amyloid plaques in the hippocampus. Inflammation and oxidative stress play an important role in the developme More

Alzheimer's disease is the most important cause of dementia in human societies and the elderly population. One of the most important symptoms of this disease is amyloid plaques in the hippocampus. Inflammation and oxidative stress play an important role in the development of Alzheimer's disease. Nerolidol is one of the many metabolites of plants and has antioxidant and anti-inflammatory properties. Therefore, the aim of this study was to evaluate the effect of nerolidol on beta amyloid-induced model of Alzheimer's in rats. 48 male Wistar rats randomly divided into 8 groups including control, sham, streptozotocin induced model of Alzheimer's, Alzheimer's and drug solvent, Alzheimer's and treatment with donepezil, Alzheimer's and treatment with nrolidol dose 50, Alzheimer's and treatment with nrolidol dose 100 and protection groups (pre-treatment with nerolidol before Alzheimer's induction). Rats weight, catalase activity, and amount of amyloid plaque were measured. Histological studies were performed by fluorescent staining. Streptozotocin increased amyloid plaques, and decreased rat's weight and catalase activity. Donepezil and nerolidol, especially at doses of 100 and in the protective group, reduced the symptoms of Alzheimer's disease through weight gain, increased catalase activity, and decreased amyloid plaques. These findings show that nerolidol can be effective in improving Alzheimer's disease and its damage, and may possibly be effective in preventing Alzheimer's in people with a family history of Alzheimer's. Manuscript profile

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3 - Profanity and obscenity in jurisprudence (by examining verse 108 of Surah An'am)
Nahid Dehghan Afifi

Insulting to things that are sacred and respected for other religions and it is a faulty act from the point of view of the holy Sharia of Islam. The important verse "La Tasabbu Al-Lazina Yadoona Men Dunellah Fayasabbu Allah Adovan Beghayre Elm" expresses this issue. It More

Insulting to things that are sacred and respected for other religions and it is a faulty act from the point of view of the holy Sharia of Islam. The important verse "La Tasabbu Al-Lazina Yadoona Men Dunellah Fayasabbu Allah Adovan Beghayre Elm" expresses this issue. It is important to note that this action can not only be done verbally, but the general verse includes any action that involves insult. On the other hand, it is not only the sanctities of religions and idols that are subject to this ruling. There are some reasons why everything that is for others, and insulting them causes insults to the holy things, including the essence of God, the saints, etc., is prohibited in the holy verse. In Islamic hadiths, obscenity towards others is forbidden. According to some jurisprudential rules, sanctity can also be deduced. Manuscript profile

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4 - Comparison of the effect of Haloperidol on changes of the ovarian tissue ultrastructure and the level of the sex steroid hormones in Trichogaster trichopterus
اورعی اورعی طاهره ناجی Homayon Hosseinzadeh sahafi

Introduction & Objective: Studies suggest that haloperidol has anti-psychotic effects through the inhibition of dopamine receptors in the nervous system. Morus alba L. leaf extract is also known as an herbal medicine with dopamine blocking effect similar to haloperi More

Introduction & Objective: Studies suggest that haloperidol has anti-psychotic effects through the inhibition of dopamine receptors in the nervous system. Morus alba L. leaf extract is also known as an herbal medicine with dopamine blocking effect similar to haloperidol. The aim of this study is to compare the effect of haloperidol and Morus alba L. leaf extract on steroid hormones and ovarian tissue ultrastructure in adult Trichogaster trichopterus fish.Materials and methods: 120 pieces of Trichogaster trichopterus adult female fish were obtained from the ornamental fish breeding workshop in Qazvin, and after preparing the aquariums, they were divided into 8 intact control groups and solvent control groups, and three groups of doses of 0.05, 0.1, and 2. 0 mg/kg of haloperidol drug and three groups of doses of 50, 100, 200 mg/kg of Morus alba L. leaf ethanol extract. Injections were done 10 times and every other day in a period of 20 days in the amount of 0.02 ml in the muscle between the dorsal fin and the lateral line of the fish. At the end of euthanasia of the fish, gonadosomatic index, steroid hormones and the ultrastructure of ovarian tissue were investigated in the treatment and control groups.Results: Haloperidol drug in all doses caused a significant decrease in gonadosomatic index, 17-beta estradiol and 17-hydroxyprogesterone hormones (P<0.05) and had no significant effect on testosterone hormone (P>0.05). While white mulberry leaf extract increased gonadosomatic index and steroid hormones (P<0.05).Conclusion: By increasing the dose of haloperidol, the level of gonadosomatic index and beta-estradiol decreased, but these effects were not dose-dependent. Also, the administration of , Morus alba L leaf ethanolic extract showed a less harmful effect on the level of sex hormones and gonadosomatic index than haloperidol. Nevertheless, it seems that the dose of 50-200 mg/kg is not sufficient and appropriate dose to observe the sexual effects of mulberry leaf plant and it is better to prescribe higher doses so that the dose-dependent effects can be observed better by increasing the concentration of flavonoids. Manuscript profile

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5 - Asbestos Presence in a Factory that Produced Asbestos-Containing Products
H. Fajković

In 2007, research was carried out to determine the type and amount of asbestos fibers in a Croatian factory with a long history of making asbestos-containing products.Since the 1970s, asbestos fibres have been considered carcinogenic in humans i.e as a known cancer-caus More

In 2007, research was carried out to determine the type and amount of asbestos fibers in a Croatian factory with a long history of making asbestos-containing products.Since the 1970s, asbestos fibres have been considered carcinogenic in humans i.e as a known cancer-causing agent. In the environment, asbestos fibres are inactive and naturally resist biodegradation. In time, fibres can only be ground into smaller particles by mechanical force. These small particles in the air present a health hazard. Because of their small size, shape and durability, asbestos fibres can easily be inhaled and stick to the lung tissue, causing serious respiratory problems. Among these are diseases with long latency periods of 10 to 40 years such as: asbestosis, mesothelioma and lung cancer. Asbestos is the generic, industrial name for a group of six minerals determined by common size and inherent physical properties. Crocidolite, amosite, anthophyllite, tremolite and actinolite are all asbestos minerals from the amphibole mineral group. The sixth mineral, chrysotile, is a mineral from the serpentine mineral group. Asbestos fibres are particles longer than, or equal to, five μm with a length to width ratio greater than or equal to 3:1; however, the ratio can be higher than 20 or even 1000. They are inflammable, thermally stable, resistant to biodegradation, chemically inert to most chemicals and have low electrical conductivity. Because of these attributes, asbestos was heartily embraced in industrial production.Different methods are used to determine the type and quantity of asbestos fibres in the air. Some of the most common methods and instruments are: polarizing light microscopy (PLM), phase contrast optical microscopy (PCM), scanning electron microscopy (SEM), analysis with electron diffraction spectra (SAED) with energy dispersive X-ray analysis (EDS), powder X-ray diffraction technique (XRD), and transmission electron microscopy (TEM). Some of above-mentioned methods (PCM, PLM, XRD) are currently popular due to their low cost, but using these methods exclusively could lead to false estimates of asbestos levels. It is hard to distinguish asbestos fibres from certain other fibres like artifacts, organic or inorganic. Therefore, it is important to observe not only the habit of minerals, but also the chemical composition of them. A combination of SEM and EDS gives information about both the habit and the chemical composition of the observed fibers, and so is suitable for asbestos analysis. Different methods of analysis are displayed and compared in this paper. Analyses were made using SEM with EDS and XRD. All samples were collected in working areas of a factory which used asbestos in production. Presence of different types of asbestos was confirmed. Manuscript profile

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6 - Rereading the Meaning and Reference of "Ṭāghūt" in the Holy Qurʿan by the Historical-Etymological Approach
mohammad ali mahdavirad hossein shojaei

Muslim commentators and lexicographers have not reached a coherent opinion about ṭāghūt, neither from literally, nor semantically, nor figuratively, and this has also caused a lot of confusion about this concept in the exegetical works. Using the etymological method, t More

Muslim commentators and lexicographers have not reached a coherent opinion about ṭāghūt, neither from literally, nor semantically, nor figuratively, and this has also caused a lot of confusion about this concept in the exegetical works. Using the etymological method, this article aims to clarify the historical meaning of this concept by illustrating the structure of this word and its origin. According to the research done in this article, it was found that ṭāghut is derived from the common Semitic root "ṬˁY/ṬĠY" which means “to make mistake, go astray”. Based on the use of this word in Jewish Aramaic texts and Christian Abyssinian texts, which are the origin of this concept entering the Arabic language, two references for ṭāghut can be found. The first reference is idols, which is borrowed from the Aramaic language, and the second reference is Kahins (shamans), which is borrowed from the Abyssinian (Geˁez) language. In the Holy Qur'an, the same two semantic spectrums are also reflected; both idol and god-like ṭaġūts are mentioned, and human ṭāghuts (which are shamans) are also mentioned. In addition to these two, ṭāghut is also used in the Qur'an in its general meaning in Semitic languages. Manuscript profile

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7 - Alfacalcidol (1-Alpha-Hydroxycholecalciferol) and Its Efficacy in Broiler Nutrition
N. Landy F. Kheiri A. Kamyab

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8 - Introducing and Studying the Kholasatoshoara ( Botkhaneh ) , idol temple , Biography
Mohaddeseh Farrokhi

Abstract         One of the methods in paying attention in the existing identity of societies is collecting and editing of the manuscripts and precise programming to identify and introduce these works. Among the manuscripts, since som More

Abstract         One of the methods in paying attention in the existing identity of societies is collecting and editing of the manuscripts and precise programming to identify and introduce these works. Among the manuscripts, since some of the biographies have kept the names and addresses of their writers, and have been survived up to now, are of specific importance. The biography of Kholasatoshoara ( botkhaneh ) is a footnote which  has been written to the miscellany of Botkhaneh. It has over four thousand stitches, a selection poetry of the ancient or contemporary poets which is collected by Mulla Mohammad Sufi Mazandarani in cooperation with Abdollatif Abbasi in 1010 A. H. and later Abdollatif Abbasi Gojarati , in addition to writing a preface to it, has added the biography of poets together with their contemporary kings and the sages in brief and has arranged it in two volumes called Kholasatoshoara. In this article, by introducing the biography and existing copies of it, we have tried to offer its stylistics specification from the view point of lingual, thought and rhetoric Manuscript profile

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