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Open Access Article
1 - Effects of Long-term administration of sildenafil citrate on serum markers of cardiac injury in the rats
Zarini, E., Amouoghli Tabrizi, B. *, Fartashvand, M., Sadeghy, R. .Nowadays, sexual impotence due to increased heart disease, has led to rising in consumption ofsexual enhancing drugs. In heart failure, due to decreased blood supply to corpus cavernosum,complete erection does not occur, which can lead to sexual dissatisfaction. One of MoreNowadays, sexual impotence due to increased heart disease, has led to rising in consumption ofsexual enhancing drugs. In heart failure, due to decreased blood supply to corpus cavernosum,complete erection does not occur, which can lead to sexual dissatisfaction. One of the mostimportant drugs which are used to treat this disorder is sildenafil citrate, a selective inhibitor oftype 5 cGMP. The purpose of this study was to evaluate the long-term side effects of this drugon serum biomarkers of cardiac injury in the rat. In this study, 20 male Wistar rats wererandomly assigned into 2 groups including: control and treatment. In treatment group, sildenafilcitrate use at a dose of 100 mg/kg for 30 consecutive days in oral rout and control group onlyreceived Distilled water. At the end of experiment, the serum levels of cardiac troponin I,creatine kinase- MB, lactate dehydrogenase and aspartate aminotransferase were measured. Theresults obtained showed that sildenafil citrate has protective effects on cardiac enzymes whichmay be in association with releasing of nitric oxide (NO). Manuscript profile -
Open Access Article
2 - A survey on the effects of citrate on canine mammary tumor cells (CF41-Mg)
Vahidi, R., Farsinejad, A., Safi, S. .Mammary tumors are among the most prevalent tumors in female dogs which according to the pathological classification have several types. These tumors have many resemblances to human tumors and can be used as a suitable model for study of human mammary tumors. Although t MoreMammary tumors are among the most prevalent tumors in female dogs which according to the pathological classification have several types. These tumors have many resemblances to human tumors and can be used as a suitable model for study of human mammary tumors. Although the antitumor effects of citrate against a variety of cancerous cells has been proven, the effect of this substance against canine mammary tumor cells has not yet been analyzed. The aim of present study was to evaluate the apoptotic and cytotoxic effects of citrate on canine mammary tumor cells(CF41-Mg) by Annexin-PI and MTT tests (a yellow tetrazole is reduced to purple formazan in living cells), respectively. MTT data showed dose dependant inhibition of citrate on proliferation of CF41-Mg cells and 50%inhibitory concentration (IC50) of this substance at a dose of26mM. In addition, percentage of apoptotic cells significantly increased after 48 hours’ treatment with IC50 of citrate (P<0/001). According to the obtained results, it seems that citrate can be used as a suitable adjuvant therapy alongside other cancer treatment substances. Manuscript profile -
Open Access Article
3 - Partitioning Studies of Alpha-amylase in Aqueous Two Phase System Composing of Polyethylene Glycol and Tri-Sodium Citrate
مریم Karimi N. Hadidi Gh. Pazuki Sh. AbdolrahimiIntroduction: One of the scenario for separation of biotechnology products is the application of aqueous two-phase systems (ATPS) rather than traditional extraction by using solvent. The ATPSs are applicable method for separation and purification of biomolecules mixture MoreIntroduction: One of the scenario for separation of biotechnology products is the application of aqueous two-phase systems (ATPS) rather than traditional extraction by using solvent. The ATPSs are applicable method for separation and purification of biomolecules mixture. The ATPS can be applied for protein purification of biomolecules from suspension broth. The goal of the present research is the study of partitioning of -amylase in polymer-salt aqueous two-phase system composed of polyethylene glycol with molecular weight of 1000 and tri-sodium citrate salt as a biocompatible salt. Materials and Methods: The aim of this research is to study partitioning of α-amylase enzyme in an aqueous two phase system. The system consists of polyethylene glycol (PEG) with molecular weight of 1000 and tri-sodium citrate that is a biocompatible salt. Results: The results for partitioning of enzyme in ATPS has been modeled and statistically analyzed; and indicated that the partition coefficient of -amylase in the system has the maximum amount of 2.681. Conclusion: In this research it has been proved that ATPS components concentration has an effect on the enzyme partition coefficient. Using experimental results, -amylase has a great tendency to be placed in the PEG rich phase. Manuscript profile -
Open Access Article
4 - The Effect of Emulsifying Salts on Physicochemical Properties and Enzymatic Gelation Time of Skim Milk
Mahdokht Ehteshami Hamid Ezzatpanah Soleyman Abbasi Mohammad Hadi GivianradIntroduction: Milk proteins are able to form gel under different situations such as heating, acidification, adding the enzymes and emulsifying salts. In this study, the effect of adding tetrasodium pyrophosphate (TSPP) and trisodium citrate (TSC) on physicochemical prop MoreIntroduction: Milk proteins are able to form gel under different situations such as heating, acidification, adding the enzymes and emulsifying salts. In this study, the effect of adding tetrasodium pyrophosphate (TSPP) and trisodium citrate (TSC) on physicochemical properties and rennet gelation time of unheated and heated skim milk was investigated. Materials and Methods: 2 to 10 mM TSPP and TSC were added to unheated and heated reconstituted skim milk. The pH, electro-conductivity (EC), and turbidity of samples were measured and upon the rennet treatment, the gelation time and water holding capacity (WHC) of treated samples were determined.Results: Based on our findings, addition of TSPP and TSC increased the pH and EC while it decreased the turbidity of the samples. Moreover, the presence of these salts extended the rennet gelation time of induced casein gels and gelation was only observed in the samples containing 2 and 4 mM TSC, and 4, 6, and 8 mM TSPP. The WHC of the samples was increased as well.Conclusion: TSPP and TSC resulted in dispersing the casein and forming a new gel networks, that can contribute to the improvement of some properties of milk products. Manuscript profile -
Open Access Article
5 - Studying of the Antioxidant and Antimicrobial Effects of Sodium Ascorbate, Sodium Acetate and Sodium Citrate on the Shelf Life of Packaged Minced Veal Meat
S. Tehraninejad A. Sharifan S. Ayoughi Poor TaftiIntroduction: Meat product are susceptible to spoilage during cold shortage due to microbial activities and fat oxidation. In this study, the application of sodium ascorbate, sodium acetate and sodium citrate as antioxidant and antimicrobial agents in packaged minced ve MoreIntroduction: Meat product are susceptible to spoilage during cold shortage due to microbial activities and fat oxidation. In this study, the application of sodium ascorbate, sodium acetate and sodium citrate as antioxidant and antimicrobial agents in packaged minced veal meat was investigated and evaluated. Materials and Methods: In order to carry out this research work, meat samples were minced and immersed in sterile solutions of sodium ascorbate, sodium citrate and sodium acetate at different concentrations for 10 minutes. The samples were packed in poly ethylene containers with stretch PVC coating and kept in 4 and -18°C for 0, 7 and 14 days. then Microbial (Aerobic mesophilic bacteria, Coliform, E. Coli, Staphylococcus aureus, Yeast and Mold count) evaluations and chemical analysis (TBA, Myoglobin concentration) and determination of color changes were carried out on the sample. Results: The results of this study showed that during 14-day review period at -18 ° C, there were significant changes in physico-chemical and microbial characteristics, therefor TBA values, pH, myoglobin concentration, color changes among the treatments, containing sodium acetate 1%, sodium citrate 0.5%, sodium ascorbate 0.5%), it was at lowest level while, in the control sample were at the highest level during storage. The use of these compounds at -18 ° C has also a significant effect on inhibiting the growth of microorganisms. Conclusion: The Addition of sodium acetate (1%), sodium citrate (0.5%) and sodium ascorbate (0.5%) are recommended in order to increase the shelf life of minced veal meat. Manuscript profile -
Open Access Article
6 - Evaluation of cardiac injury biomarkers in serum following concomitant administration of sildenafil citrate with dextromethorphan and chlorpheniramine in rat
Rasol Sadeghy B. Amouoghli Tabrizi majid fartashvandSildenafil citrate is an inhibitor of the enzyme phosphodiesterase 5, dextromethorphan is an antitussive with weak opioid effects, and chlorpheniramine is a first-generation antihistamine. Since cardiovascular complications related to all three drugs have been reported, MoreSildenafil citrate is an inhibitor of the enzyme phosphodiesterase 5, dextromethorphan is an antitussive with weak opioid effects, and chlorpheniramine is a first-generation antihistamine. Since cardiovascular complications related to all three drugs have been reported, the aim of this study was to evaluate the serum levels of cardiac damage index enzymes and tropovinin I following co-administration of sildenafil with dextromethorphan and chlorpheniramine. Forty male Wistar rats were studied in 8 groups, one control group and the rest in the treatment group; Drugs sildenafil citrate (100 mg / kg), dextromethorphan (20 mg / kg), chlorpheniramine (20 mg / kg), dextromethorphan + chlorpheniramine, sildenafil + dextromethorphan, sildenafil + chlorpheniramine, sildenafil + rosemethor + dextrometer , Received food. The results showed that administration of sildenafil to rats did not cause statistically significant changes in serum cardiac injury indices compared with the control group (p < 0.05); The amount of CK-MB also decreased compared to the control group. On the other hand, following administration of chlorpheniramine and dextromethorphan to rats, either alone or in combination, serum levels of AST, LDH and CK-MB increased statistically significantly. Administration of chlorpheniramine caused a significant increase in LDH (p < 0.01) and CK-MB (p < 0.001) compared to the control group and administration of dextromethorphan increased the activity of the studied enzymes which increased AST (p < 0.05). ) And CK-MB (p < 0.001) were significant. Co-administration of sildenafil with dextromethorphan and sildenafil with chlorpheniramine or all three together increased the activity of all three enzymes in the heart damage index. Manuscript profile -
Open Access Article
7 - Structural and mechanical properties of AFe2O4 (A = Zn, Cu0.5Zn0.5, Ni0.3Cu0.2Zn0.5) nanoparticles prepared by citrate method at low temperature
Ahmad Gholizadeh -
Open Access Article
8 - Structural and mechanical properties of AFe2O4 (A = Zn, Cu0.5Zn0.5, Ni0.3Cu0.2Zn0.5) nanoparticles prepared by citrate method at low temperature
Ahmad Gholizadeh -
Open Access Article
9 - Rapid Synthesis of Silver Nanoparticles and Their Decoration on TiO2 by Plasma-Over-Liquid Process: Characterization and Application for Tetracycline Antibiotic Degradation
Margarita Skiba Victoria Vorobyova -
Open Access Article
10 - Estrus Synchronization Methods during the Non-Breeding Season of Ghezel Ewe Lambs
M. Ebrahimi R. Aghamohammadzadeh G. Moghaddam H. Daghigh Kia -
Open Access Article
11 - Leaching of heavy metal from native plants by chemical leachants
Fatemeh Akbarpour Mohamad Akbarpour Majid Seyri -
Open Access Article
12 - Effect of the ionic liquid 1-butyl-3-methyl-imidazolium bromide as adjuvant on the formation of {PEG 600-potassium citrate} aqueous biphasic system at different temperatures
Sholeh Hamzehzadeh Mostafa AbbasiAbstract: In biotechnology, separation, extraction, and purification of biomolecules using aqueous biphasic systems, as environmental and economic sustainable alternatives for conventional water-organic solvent extraction techniques, have always been the focus of great MoreAbstract: In biotechnology, separation, extraction, and purification of biomolecules using aqueous biphasic systems, as environmental and economic sustainable alternatives for conventional water-organic solvent extraction techniques, have always been the focus of great attention and examina-tion. One approach proposed by researchers is based on the use of ionic liquids (ILs) as adjuvants in ABS, making the capability of these systems for the extraction of biomolecules to be promoted. In this regard, this work is devoted to study the effect of IL 1-butyl-3-methyl imidazolium bromide ([C4C1im] Br) on the formation of ABS Composed of a polyethylene glycol (PEG) with molecular weight 600 and a biodegradable organic salt potassium citrate. For this purpose, the binodal curves and the liquid-liquid equilibrium (LLE) data of the studied ABS, along with the partition coeffi-cients of [C4C1im]Br were determined at two temperatures of 278.15 K and 318.15 K. The results obtained indicate that the ability of [C4C1im]Br to promote the formation of the studied ABS de-creases with increasing temperature, so that at 318.15 K, the addition of IL makes the formation of two-phase system more difficult. In addition, [C4C1im]Br displays the partition coefficients greater than one for all the compositions and temperatures studied, which increases with increasing TLL at a given temperature. Manuscript profile -
Open Access Article
13 - Electrocatalytic activity of Pt/C nanocatalyst stabilized by different amounts of sodium citrate in oxygen reduction reaction
Kulthum Mehrabinejad Mehdi KheirmandIn the present study, Pt(20wt%)/C electrocatalysts for oxygen reduction reaction in the cathode of fuel cells were synthesized with different amounts of trisodium citrate as stabilizing agent, to achieve higher efficiency of platinum electrocatalyst. The electrocatalyst MoreIn the present study, Pt(20wt%)/C electrocatalysts for oxygen reduction reaction in the cathode of fuel cells were synthesized with different amounts of trisodium citrate as stabilizing agent, to achieve higher efficiency of platinum electrocatalyst. The electrocatalysts containing platinum and trisodium citrate with ratios of 1:12, 1:9, 1:6, and 1:3 (Pt/C:TC) were prepared by using the saturation-reduction method. To evaluate the oxygen reduction reaction in the cathode catalyst layer in an acidic environment cyclic voltammetry (CV), linear sweep voltammetry (LSV), rotating disk electrode (RDE), and finally electrochemical impedance spectroscopy (EIS) techniques were applied. Also, morphology of the catalysts was studied with scanning electron microscopy (SEM). The results showed that the efficiency of the synthesized electrocatalysts at a ratio of 1:3 (Pt/C:TC) was better for oxygen reduction. It also had lower charge transfer resistance, more suitable distribution, and higher electrochemically active surface area (14.7 m2gPt). In addition, the number of electrons involved in the oxygen reduction reaction was calculated to follow the four-electron pathway for the electrocatalyst prepared at ratio of 1:3. Manuscript profile -
Open Access Article
14 - The effect of pulsing and continuous treatments of chemical preserving solutions on increasing the vase life and quality of cut carnations (Dianthus caryophyllus L., cv.Yellow Candy)
Masoud Zadehbagheri anita namayandeh mohammadreza solati shurangiz javanmardiCarnations are one of the most common cut flowers in many countries and have economic importance in the floriculture industry. Their vase life duration could be increased by some methods. The aim of this study was to assess the effect of some chemical solutions on cut c MoreCarnations are one of the most common cut flowers in many countries and have economic importance in the floriculture industry. Their vase life duration could be increased by some methods. The aim of this study was to assess the effect of some chemical solutions on cut carnations (Dianthus caryophyllus) after harvest using a factorial statistical design based on a completely random blocks (factor A: chemical treatments with eight levels including, control, sucrose, HQC350 & 500 mg L-1, salicylic acid 300 & 400 mg L-1, Calcium acetate 2 & 3 mmol L-1 and factor B: duration of treatment application with 4 levels including 7, 14, 21 and continuous hours) and with three replications and evaluation of vase life, fresh weight, water absorption and appearance quality of the flowers. The results of variance analysis showed that chemical treatments had a significant effect on the studied characteristics. The period for solution intake was also significant regarding the studied characteristics (except water absorption). The effect of interaction of the type of solution and time of solution intake was significant for all characteristics. The results of mean comparison showed that Calcium acetate 2ml had the highest effect on the shelf life of the flower and the 8-HQC500 had the most effect on the fresh weight of the flowers. Its apparent quality and finally the 8-HQC350 treatment had the most effect on the flower's water absorption. Salicylic acid also had a beneficial effect on increasing the quality of cut carnations. The pulsing treatment had the highest effect on most of the studied characteristics after a 7-hour solution intake. Generally, the role of Calcium acetate on improving the quality of cut carnations is due to its effect on postponing and deactivating some destructive and physiologic processes with the help of Calcium. Moreover, the HQC treatments, due to its anti-microbial effect, revents the accumulation of micro-organisms in xylem vascular tissues and therefore prevents their obstruction. Manuscript profile
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