List of Articles Cardiac Troponin

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  1 - Effects of Long-term administration of sildenafil citrate on serum markers of cardiac injury in the rats
  Zarini, E., Amouoghli Tabrizi, B. *, Fartashvand, M., Sadeghy, R. .
  Nowadays, sexual impotence due to increased heart disease, has led to rising in consumption ofsexual enhancing drugs. In heart failure, due to decreased blood supply to corpus cavernosum,complete erection does not occur, which can lead to sexual dissatisfaction. One of More

  Nowadays, sexual impotence due to increased heart disease, has led to rising in consumption ofsexual enhancing drugs. In heart failure, due to decreased blood supply to corpus cavernosum,complete erection does not occur, which can lead to sexual dissatisfaction. One of the mostimportant drugs which are used to treat this disorder is sildenafil citrate, a selective inhibitor oftype 5 cGMP. The purpose of this study was to evaluate the long-term side effects of this drugon serum biomarkers of cardiac injury in the rat. In this study, 20 male Wistar rats wererandomly assigned into 2 groups including: control and treatment. In treatment group, sildenafilcitrate use at a dose of 100 mg/kg for 30 consecutive days in oral rout and control group onlyreceived Distilled water. At the end of experiment, the serum levels of cardiac troponin I,creatine kinase- MB, lactate dehydrogenase and aspartate aminotransferase were measured. Theresults obtained showed that sildenafil citrate has protective effects on cardiac enzymes whichmay be in association with releasing of nitric oxide (NO). Manuscript profile
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  2 - Evaluation of cardiac injury biomarkers of serum in alloxan induced diabetic rats
  Yaghoub Haji-Sadeghi majid fartashvand
  Diabetes mellitus is a metabolic disorder and its incidence is considered to be high all over the world. It causes increase in blood glucose levels and subsequent damage to various tissues and blood vessels. The aim of the present study was to evaluate cardiac injury bi More

  Diabetes mellitus is a metabolic disorder and its incidence is considered to be high all over the world. It causes increase in blood glucose levels and subsequent damage to various tissues and blood vessels. The aim of the present study was to evaluate cardiac injury biomarkers of serum in rats with experimental diabetes. Thirty male Wistar rats were randomly assigned into 2 groups including healthy control and diabetic rats. Diabetes was induced with a single injection of alloxan (120 mg/kg IP). Four weeks after induction of diabetes, levels of cTnI (cardiac troponin I), AST (Aspartate aminotransferase), LDH (lactate dehydrogenase) and CK-MB (keratin kinase) were measured in serum. At the end of the experiment, mean blood sugar levels were 263.1 ± 36 and 96.7 ± 12 mg/dl in diabetic and control groups respectively that reveals a statistically significant difference between the two groups (p=0.000). Serum cTnI level in diabetic rats was significantly higher than healthy control group (p=0.002). Other cardiac biomarkers of serum in experimentally induced diabetic rats were significantly higher than control group. There were significant correlation between blood glucose levels and serum cTnI (r=0.685; p=0.010), and with serum activities of enzymes, including AST (r=0.862; p=0.000), LDH (r=0.760; p=0.008) and CK-MB (r=0.590; p=0.014). In conclusion, elevated level of serum cTnI and enzyme activities in diabetic rats in comparison to the control group suggests some degree of cardiac muscle damages. Manuscript profile
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  3 - Evaluation of serum homocysteine and cardiac troponin I in sheep with theileriosis in Urmia city
  Kaveh Azimzadeh Asghar Hasanpour
  Theileriosis is an important protozoal disease of domestic animals with a substantial role in reduction of production (milk and meat). The aim of the present study was to evaluate serum homocysteine and cardiac troponin I as biomarkers of cardiovascular damage in sheep More

  Theileriosis is an important protozoal disease of domestic animals with a substantial role in reduction of production (milk and meat). The aim of the present study was to evaluate serum homocysteine and cardiac troponin I as biomarkers of cardiovascular damage in sheep affected by theileriosis based on gender and breed in Urmia city. After diagnosis of theileriosis based on clinical and laboratory symptoms, 30 infected sheep were selected (15 Ghezel breed and 15 Makouei breed) with 8 males and 7 females from each breed. Meanwhile, the same number of healthy sheep (based on sex and breed) were selected as healthy group. Thereafter, blood samples were taken from the jugular vein in both groups and the previously mentioned parameters were measured and evaluated statistically. The results showed a significant increase (p≤0.05) in all parameters in diseased sheep in comparison to healthy ones. In terms of gender, significant increase in all parameters were observed in males compared with females and in the case of breed, there was a significant difference between the Makouei breed with healthy sheep and Ghezel with healthy ones (p≤ 0.05). Overall, it can be concluded that increase of serum homocysteine and cardiac troponin I in sheep with theileriosis, especially in males, could be a warning that careful attention should be paid to the prevention and treatment of sheep with theileriosis. Manuscript profile
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  4 - Evaluation of cardiac injury biomarkers in serum following concomitant administration of sildenafil citrate with dextromethorphan and chlorpheniramine in rat
  Rasol Sadeghy B. Amouoghli Tabrizi majid fartashvand
  10.30495/jvcp.2021.1922087.1296
  Sildenafil citrate is an inhibitor of the enzyme phosphodiesterase 5, dextromethorphan is an antitussive with weak opioid effects, and chlorpheniramine is a first-generation antihistamine. Since cardiovascular complications related to all three drugs have been reported, More

  Sildenafil citrate is an inhibitor of the enzyme phosphodiesterase 5, dextromethorphan is an antitussive with weak opioid effects, and chlorpheniramine is a first-generation antihistamine. Since cardiovascular complications related to all three drugs have been reported, the aim of this study was to evaluate the serum levels of cardiac damage index enzymes and tropovinin I following co-administration of sildenafil with dextromethorphan and chlorpheniramine. Forty male Wistar rats were studied in 8 groups, one control group and the rest in the treatment group; Drugs sildenafil citrate (100 mg / kg), dextromethorphan (20 mg / kg), chlorpheniramine (20 mg / kg), dextromethorphan + chlorpheniramine, sildenafil + dextromethorphan, sildenafil + chlorpheniramine, sildenafil + rosemethor + dextrometer , Received food. The results showed that administration of sildenafil to rats did not cause statistically significant changes in serum cardiac injury indices compared with the control group (p < 0.05); The amount of CK-MB also decreased compared to the control group. On the other hand, following administration of chlorpheniramine and dextromethorphan to rats, either alone or in combination, serum levels of AST, LDH and CK-MB increased statistically significantly. Administration of chlorpheniramine caused a significant increase in LDH (p < 0.01) and CK-MB (p < 0.001) compared to the control group and administration of dextromethorphan increased the activity of the studied enzymes which increased AST (p < 0.05). ) And CK-MB (p < 0.001) were significant. Co-administration of sildenafil with dextromethorphan and sildenafil with chlorpheniramine or all three together increased the activity of all three enzymes in the heart damage index. Manuscript profile
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  5 - Evaluation of cardiac troponin I alterationsin dairy cattle with septicmetritis
  majid fartashvand ali derangian amirali kaveh
  Metritis is an important disease in dairy cattle which causes economical loses including decrease in milk yield, increase calving interval, treatment costs and death of ill cases. Septic metritis usually occurs within 2-10 days after parturition, and characterized clini More

  Metritis is an important disease in dairy cattle which causes economical loses including decrease in milk yield, increase calving interval, treatment costs and death of ill cases. Septic metritis usually occurs within 2-10 days after parturition, and characterized clinically with sever toxemia associated with purulent odorous uterine discharge with or without retained placenta. In this study, serum levels of cTnI were measured in 50 female Holstein cattle with septicmetritis and compared with normal cows. cTnI of serum in disease and control groups were 0.017 ± 0.008 and 0.005 ± 0.000 ng/dl, respectively. Heart rate, respiratory rate and rectal temperature in disease cases were significantly higher than normal cattle. There was significant correlation with cTnI and heart rate and rectal temperature. Endotoxemia is one of possible reasons of elevation of serum cTnI. Cytokines and endotoxins originated from gram negative bacteria that cause myocardium depression and ventricular dilatation. Furthermore impairment of left ventricle function is a significant effect of septic shock.   Manuscript profile
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  6 - Serumic concentration of cardiac troponin and some enzymes in horses with strangles
  علی Hassanpour مجید Fartashvand
  This study was conducted on horses to investigate the effect of strangles on cardiac troponin fluctuations and activity of some serum enzymes. The research was done on 30 horses with strangles and 29 normal horses. Sick horses were confirmed on the basis of clinical and More

  This study was conducted on horses to investigate the effect of strangles on cardiac troponin fluctuations and activity of some serum enzymes. The research was done on 30 horses with strangles and 29 normal horses. Sick horses were confirmed on the basis of clinical and laboratory signs (culture of nasal and lymph nodes discharges for Streptococcus equi). Blood samples were taken from the jugular vein. The serum activity of cardiac troponin was measured by ELISA kit and gama gluthamil transferase (GGT), alanine amino tramsferase (ALT), aspartate amino transferase (AST), creatine kinase (CK) and alkaline phosphatase (ALP) were measured by biochemical kits. The mean heart rate increased significantly (p<0.05) in horses with strangles. The mean cardiac troponin also increased significantly (p=0.001). Serum activity of GGT, CK, ALP and ALT enzymes were increased significantly (p= 0.41, p= 0.006 and p=0.001, respectively) in horses with strangles. In conclusion, serumic concentration of cardiac troponin and GGT, CK, ALP and ALT enzymes increase after strangles in the horse. Manuscript profile
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  7 - The Effect of an Aerobic Activity Course in Reducing the Side Effects of Anabolic Steroids with Different Dosages on some Biochemical and Histopathological Indicators of Heart Tissue in Male Wistar Rats
  Iman Mazji Ebrahim SHEKH-NAZARI Asieh Abbasi-daloii Sayyed-Javad Ziaolhagh
  10.22034/ascij.2022.1946660.1346
  In addition to their therapeutic purposes, steroids have been abused a lot and have had many side effects. Therefore, this study aims at investigating the effect of eight weeks of aerobic exercise on structural and biochemical changes in the heart tissue of male Wistar More

  In addition to their therapeutic purposes, steroids have been abused a lot and have had many side effects. Therefore, this study aims at investigating the effect of eight weeks of aerobic exercise on structural and biochemical changes in the heart tissue of male Wistar rats receiving therapeutic dosages and abuse of Boldenone steroid. Therefore, 49 male rats with 12 weeks of age and 190 g mean weight were divided into 7 groups: control group, sham, therapeutic dosage (2 mg / kg), abuse dosage (5 mg / kg), aerobic exercise, aerobic exercise + therapeutic dosage and aerobic exercise + abuse dosage. Injections were given in the same day of the week on the back of rats with a graduated insulin syringe and placebo was used. The aerobic protocol included running five days a week for eight weeks on a rodent treadmill at a speed of 30 meters per minute and 60 minutes training. The samples were first anesthetized and blood and tissue samples were transferred to the relevant laboratories. The results were also analyzed by SPSS software and one-way analysis of variance and Bonferroni post hoc test with a significance level of 0.05. The results showed that there was no significant difference between the groups in final weight gain and cardiac troponin (p <0.05). Also, plasma testosterone levels in steroid-receiving rats decreased significantly in both therapeutic and abusive dosages compared to the exercise groups (p <0.05). On the other hand, the amount of running distance in rodent aerobic function test in steroid and exercise groups was significantly higher than other groups (p <0.05). Generally, data showed that aerobic exercise can prevent the reduction of endogenous testosterone but it has no effect on cardiac troponin levels and rat weight. In addition, Boldenone steroid appears to be effective on increasing the aerobic function of rats. Manuscript profile