Evaluation of serum homocysteine and cardiac troponin I in sheep with theileriosis in Urmia city
Subject Areas :
Veterinary Clinical Pathology
Kaveh
Azimzadeh
1
(Assistant Professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran.)
Asghar
Hasanpour
2
(Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran.)
Received: 2017-07-09
Accepted : 2017-12-02
Published : 2018-04-21
Keywords:
Homocysteine,
Sheep,
Cardiac troponin I,
Theileriosis,
Abstract :
Theileriosis is an important protozoal disease of domestic animals with a substantial role in reduction of production (milk and meat). The aim of the present study was to evaluate serum homocysteine and cardiac troponin I as biomarkers of cardiovascular damage in sheep affected by theileriosis based on gender and breed in Urmia city. After diagnosis of theileriosis based on clinical and laboratory symptoms, 30 infected sheep were selected (15 Ghezel breed and 15 Makouei breed) with 8 males and 7 females from each breed. Meanwhile, the same number of healthy sheep (based on sex and breed) were selected as healthy group. Thereafter, blood samples were taken from the jugular vein in both groups and the previously mentioned parameters were measured and evaluated statistically. The results showed a significant increase (p≤0.05) in all parameters in diseased sheep in comparison to healthy ones. In terms of gender, significant increase in all parameters were observed in males compared with females and in the case of breed, there was a significant difference between the Makouei breed with healthy sheep and Ghezel with healthy ones (p≤ 0.05). Overall, it can be concluded that increase of serum homocysteine and cardiac troponin I in sheep with theileriosis, especially in males, could be a warning that careful attention should be paid to the prevention and treatment of sheep with theileriosis.
References:
Azimzadeh, K. (2017). Ovine theileriosis enhances cardiovascular disease biomarkers in naturally infected sheep (ghezel breed) in West Azerbaijan, Iran. İstanbul Ünivsitesi Veterinary Fakultesi Dergisi, 43(1): 61-66.
Babuin, L. and Jaffe, A.S. (2005). Troponin: the biomarker of choice for the detection of cardiac injury. Canadian Medical Association Journal, 173(10): 1191-1202.
Baghishani, H., Razmi, G.R., Yaghfoori, S. and Ahmadi, A. (2012). Investigation of selected biochemical parameters in sheep naturally infected with theileriosis. Comparative Clinical Pathology, 21(6): 1417-1420.
Col, R. and Uslu, U. (2006). Haematological and coagulation profiles during severe tropical theileriosis in cattle. Turkish Journal of Veterinary and Animal Science, 30: 577-582.
Collinson, P.O. and Gaze, D.C. (2007). Biomarkers of cardiovascular damage and dysfunction– an overview. Heart Lung Circulation, 16(3): 71-82.
Fartashvand, M., Nadalian, M.G., Sakha, M. and Safi, S. (2013). Elevated serum cardiac troponin I in cattle with theileriosis. Journal of Veterinary Internal Medicine, 27(1): 194-199.
Ganguly, P. and Alam, S.F. (2015). Role of homocysteine in the development of cardiovascular disease. Nutrition Journal, 14: 6.
Gill, B.S., Bhattacharyulu, Y. and Kaur, D. (1977). Symptoms and pathology of experimental bovine tropical theileriosis (Theileria annulata infection). Annales De Parasitologie Humaine Et Comparee, 52(6): 597-608.
Hashemi-Fesharaki, R. (1997). Tick-borne diseases of sheep and goats and their related vectors in Iran. Parasitologia, 39(2): 115-117.
Hatazoe, T., Kubota, C., Fujiki, M. and Misumi, K. (2012). Mating behavior increases workload of the heart in thoroughbred stallions. Journal of Veterinary Medicine Science, 74(4): 423-428.
Kimmel, S.E. (2000). Sex and myocardial infarction: An epidemiologic perspective. American Journal of Cardiology, 86(2): 10-13.
Kirbas, A., Baydar E., Kandemir, F.M. and Dorman, E. (2014). Evaluation of serum cardiac troponin I concentration in sheep with acute ruminal lactic acidosis. Veterinarski Arhiv, 84(4): 355-364.
Lai, W.K.C. and Kan, M.Y. (2015). Homocysteine-induced endothelial dysfunction. Annals of Nutrition and Metabolism, 67(1): 1-12.
Lobetti, R., Dvir, E. and Pearson, J. (2002). Cardiac troponins in canine babesiosis. Journal of Veterinary Internal Medicine, 16(1): 63-68.
Nazifi, S., Razavi, S.M., Safi, N. and Rakhshandehroo, E. (2012). Malignant ovine theileriosis: Alterations in the levels of homocysteine, thyroid hormones and serum trace elements. Journal of Bacteriology and Parasitology, 3(7): 1-4.
Nehler, M.R., Talor, L.M. and Porter, J.M. (1997). Homocysteine as a risk factor for atherosclerosis: a review. Journal of Cardiovascular Surgery, 5(6): 559-567.
O'Brien, P.J. (2008). Cardiac troponin is the most effective translational safety biomarker for myocardial injury in cardiotoxicity. Toxicology, 245: 206-218.
Omer, O.H., El-Malik, K.H., Mahmoud, O.M., Haroun, E.M., Hawas, A., Sweeney, D., et al. (2002). Haematological profiles in purebred cattle naturally infected with Theileria annulata in Saudi Arabia. Veterinary Paasitology, 107(1-2): 161-168.
Perna, A.F., Ingrosso, D. and De Santo, N.G. (2003). Homocysteine and oxidative stress. Amino Acids, 25(3-4): 409-417.
Razmi, G.R., Barati, F. and Aslani, M.R. (2009). Prevalence of Theileria annulata in dairy cattle in Mashhad area. Iranian Journal of Veterinary Parasitology, 23(1): 81-83.
Razavi, S.M., Nazifi, S., Hasani, S. and Rakhshandehroo, E. (2015). Bovine tropical theileriosis: effects on the cardiovascular system on the basis of serum analysis. Complementary Clinical Pathology, 24(1): 29-33.
Shahnawaz, S., Ali, M., Aslam, M.A., Fatima, R., Chaudhry, Z.L., Hassan, M.U., et al. (2011). A study on the prevalence of a tick-transmitted pathogen, Theileria annulata, and hematological profile of cattle from Southern Punjab (Pakistan). Parasitology Research, 109(4): 1155-1160.
Soulsby, E.J.L. (1982). Helminths, Arthropods and Protozoa of Domesticated Animals. London: Baillière Tindall, pp: 728-741.
Terada, M., Momozawa, Y., Komano, M., Kusunose, R., Sato F. and Sait, T.R. (2005). Changes in the heart rate and plasma epinephrine and norepinephrine concentrations of the stallion during copulation. Reproductive Medicine and Biology, 4(2): 143-147.
Tunca, R., Sozmen, M., Erdogan, H., Citil, M., Uzlu, E., Ozen, H., et al. (2008). Determination of cardiac troponin I in the blood and heart of calves with foot-and-mouth disease. Journal of Veterinary Diagnosis Investigation. 20(5): 598-605.
Yaghfoori, S., Razmi, G.R., Mohri, M., Taghavi Razavizadeh, A.R. and Movassaghi, A.R. (2016). An experimental ovine Theileriosis: The effect of Theileria lestoquardi infection on cardiovascular system in sheep. Acta Tropica, 161: 55-61.
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Azimzadeh, K. (2017). Ovine theileriosis enhances cardiovascular disease biomarkers in naturally infected sheep (ghezel breed) in West Azerbaijan, Iran. İstanbul Ünivsitesi Veterinary Fakultesi Dergisi, 43(1): 61-66.
Babuin, L. and Jaffe, A.S. (2005). Troponin: the biomarker of choice for the detection of cardiac injury. Canadian Medical Association Journal, 173(10): 1191-1202.
Baghishani, H., Razmi, G.R., Yaghfoori, S. and Ahmadi, A. (2012). Investigation of selected biochemical parameters in sheep naturally infected with theileriosis. Comparative Clinical Pathology, 21(6): 1417-1420.
Col, R. and Uslu, U. (2006). Haematological and coagulation profiles during severe tropical theileriosis in cattle. Turkish Journal of Veterinary and Animal Science, 30: 577-582.
Collinson, P.O. and Gaze, D.C. (2007). Biomarkers of cardiovascular damage and dysfunction– an overview. Heart Lung Circulation, 16(3): 71-82.
Fartashvand, M., Nadalian, M.G., Sakha, M. and Safi, S. (2013). Elevated serum cardiac troponin I in cattle with theileriosis. Journal of Veterinary Internal Medicine, 27(1): 194-199.
Ganguly, P. and Alam, S.F. (2015). Role of homocysteine in the development of cardiovascular disease. Nutrition Journal, 14: 6.
Gill, B.S., Bhattacharyulu, Y. and Kaur, D. (1977). Symptoms and pathology of experimental bovine tropical theileriosis (Theileria annulata infection). Annales De Parasitologie Humaine Et Comparee, 52(6): 597-608.
Hashemi-Fesharaki, R. (1997). Tick-borne diseases of sheep and goats and their related vectors in Iran. Parasitologia, 39(2): 115-117.
Hatazoe, T., Kubota, C., Fujiki, M. and Misumi, K. (2012). Mating behavior increases workload of the heart in thoroughbred stallions. Journal of Veterinary Medicine Science, 74(4): 423-428.
Kimmel, S.E. (2000). Sex and myocardial infarction: An epidemiologic perspective. American Journal of Cardiology, 86(2): 10-13.
Kirbas, A., Baydar E., Kandemir, F.M. and Dorman, E. (2014). Evaluation of serum cardiac troponin I concentration in sheep with acute ruminal lactic acidosis. Veterinarski Arhiv, 84(4): 355-364.
Lai, W.K.C. and Kan, M.Y. (2015). Homocysteine-induced endothelial dysfunction. Annals of Nutrition and Metabolism, 67(1): 1-12.
Lobetti, R., Dvir, E. and Pearson, J. (2002). Cardiac troponins in canine babesiosis. Journal of Veterinary Internal Medicine, 16(1): 63-68.
Nazifi, S., Razavi, S.M., Safi, N. and Rakhshandehroo, E. (2012). Malignant ovine theileriosis: Alterations in the levels of homocysteine, thyroid hormones and serum trace elements. Journal of Bacteriology and Parasitology, 3(7): 1-4.
Nehler, M.R., Talor, L.M. and Porter, J.M. (1997). Homocysteine as a risk factor for atherosclerosis: a review. Journal of Cardiovascular Surgery, 5(6): 559-567.
O'Brien, P.J. (2008). Cardiac troponin is the most effective translational safety biomarker for myocardial injury in cardiotoxicity. Toxicology, 245: 206-218.
Omer, O.H., El-Malik, K.H., Mahmoud, O.M., Haroun, E.M., Hawas, A., Sweeney, D., et al. (2002). Haematological profiles in purebred cattle naturally infected with Theileria annulata in Saudi Arabia. Veterinary Paasitology, 107(1-2): 161-168.
Perna, A.F., Ingrosso, D. and De Santo, N.G. (2003). Homocysteine and oxidative stress. Amino Acids, 25(3-4): 409-417.
Razmi, G.R., Barati, F. and Aslani, M.R. (2009). Prevalence of Theileria annulata in dairy cattle in Mashhad area. Iranian Journal of Veterinary Parasitology, 23(1): 81-83.
Razavi, S.M., Nazifi, S., Hasani, S. and Rakhshandehroo, E. (2015). Bovine tropical theileriosis: effects on the cardiovascular system on the basis of serum analysis. Complementary Clinical Pathology, 24(1): 29-33.
Shahnawaz, S., Ali, M., Aslam, M.A., Fatima, R., Chaudhry, Z.L., Hassan, M.U., et al. (2011). A study on the prevalence of a tick-transmitted pathogen, Theileria annulata, and hematological profile of cattle from Southern Punjab (Pakistan). Parasitology Research, 109(4): 1155-1160.
Soulsby, E.J.L. (1982). Helminths, Arthropods and Protozoa of Domesticated Animals. London: Baillière Tindall, pp: 728-741.
Terada, M., Momozawa, Y., Komano, M., Kusunose, R., Sato F. and Sait, T.R. (2005). Changes in the heart rate and plasma epinephrine and norepinephrine concentrations of the stallion during copulation. Reproductive Medicine and Biology, 4(2): 143-147.
Tunca, R., Sozmen, M., Erdogan, H., Citil, M., Uzlu, E., Ozen, H., et al. (2008). Determination of cardiac troponin I in the blood and heart of calves with foot-and-mouth disease. Journal of Veterinary Diagnosis Investigation. 20(5): 598-605.
Yaghfoori, S., Razmi, G.R., Mohri, M., Taghavi Razavizadeh, A.R. and Movassaghi, A.R. (2016). An experimental ovine Theileriosis: The effect of Theileria lestoquardi infection on cardiovascular system in sheep. Acta Tropica, 161: 55-61.
