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Open Access Article
1 - Role of Adenosine A2A receptors on 6-Hydroxydopmaine-induced catalepsy in rats
S. Reyhani-Rad, J. Mahmoudi,Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease in ageingindividuals. This movement disorder caused by degeneration of dopaminergic neurons from thesubstantia nigra pars compacta (SNc). Caffeine consumption has been proposed to be a MoreParkinson’s disease (PD) is the second most prevalent neurodegenerative disease in ageingindividuals. This movement disorder caused by degeneration of dopaminergic neurons from thesubstantia nigra pars compacta (SNc). Caffeine consumption has been proposed to be associatedwith a reduced risk of Parkinson’s disease and caffeine in rodent models has protective effects.We have shown that caffeine and SCH58261 as A2A receptor antagonists improve motordysfunctions induced by 6-hydroxydopamine (animal model of Parkinson’s disease) in rats. Thepresent study extends these findings by investigating the role of A2A receptors on motor disorderinduced by unilateral infusion of 6-OH-dopamine into the substantia nigra, compact part (SNc)in rat. The experimental study was carried out on 72 male Wistar rats weighing between 180-200 g. Animals were divided into the groups contain 8 rats per group and were kept in standardcondition. 6-OHDA-induced catalepsy was assessed by using bar test. Caffeine (30 mg/kg i.p.)attenuated catalepsy on bar test in parkinsonian rats (P<0.001), whereas with dose of 10 mg/kgdid not produce significant effect (P>0.05). SCH58261 (2 mg/kg i.p) significantly improvedcatalepsy in bar test (P<0.001) in parkinsonian rat. These findings suggest that A2A receptors areinvolved in 6-OHDA-induced motor deficit like catalepsy. It seems that attenuating of catalepsymay caused by inhibition of A2A receptors. Manuscript profile -
Open Access Article
2 - The Effect of Combined Training and Caffeine Supplementation on Toll-like Receptor 2 (TLR2), TLR4, and Dectin-1 in Obese Men
SH. Ghaderi Goodarzi A. Abbassi Daloii A. Abdi A. SaeidiIntroduction: Overweight and obesity are associated with increased inflammatory conditions and metabolic disorders. A therapeutic agent that can suppress metabolic and immune disorders may effectively ameliorate parallel abnormalities in obesity. The aim of this study w MoreIntroduction: Overweight and obesity are associated with increased inflammatory conditions and metabolic disorders. A therapeutic agent that can suppress metabolic and immune disorders may effectively ameliorate parallel abnormalities in obesity. The aim of this study was to evaluate the effect of combined training and caffeine supplementation on Toll-like receptor 2 (TLR2), TLR4, and dectin-1 in obese men. Materials and Methods: In a semi-experimental trial, 44 obese men were purposefully and accessibly selected and randomly divided into four groups: 1) control, 2) combined training, 3) caffeine and 4) combined training -caffeine. Subjects received 6 mg of caffeine per kilogram of body weight daily for 12 weeks. The combined training program include circular resistance training (3 times with 14 repetitions at 50% of one maximum repetition and 30 seconds rest between each station) and aerobic exercise (70% maximum heart rate for 30 minutes) was performed 3 sessions per week for 12 weeks. The combined training program was performed for 12 weeks and 3 sessions per week. Data were analyzed with covariance analysis and Tukey post hoc test at the p<0.05.Results: The results showed that 12 weeks of combined training, caffeine and combined training - caffeine significantly reduced serum levels of TLR2, TLR4 and Dectin-1 (P=0.001). The reduce of serum levels of TLR2, TLR4 and Dectin-1 were significant in the combined training compared to caffeine group (P=0.001). the effect of interactive combined training with caffeine was more than supplementation and training alone.Conclusion: According to the findings, it is suggested that combined training intervention with caffeine consumption be used in order to reduce its inflammatory effects associated with obesity. Manuscript profile -
Open Access Article
3 - The effect of caffeine intake on the risk of cardiovascular disease
Mehdi Ahmadifar نازیلا وحیدی ایریسفلی1 غلامحسین واعظی حسن باقری یزدی ناصر کلهر Reihane NateghiIntroduction:Caffeine is a chemical and edible substance, which is found in some foods, such as coffee, cocoa, cola, tea, chocolate and some drinks. Caffeine is the most widely used drug among people and almost 90 percent of people are using it on a daily basis. Given t MoreIntroduction:Caffeine is a chemical and edible substance, which is found in some foods, such as coffee, cocoa, cola, tea, chocolate and some drinks. Caffeine is the most widely used drug among people and almost 90 percent of people are using it on a daily basis. Given that taking food and drinks containing caffeine including chocolate, tea and coffee is very high in Iran as well as its effects on cardiovascular disease is still not fully understood; hence, the purpose of this research was to study the effects of caffeine on cardiovascular diseases and to report the results of research conducted in this regard.Research Methodology: In this study, library collection, searching the scientific literature and papers were used. The views of relevant experts were also examined.Results:The results showed that using tea has no harmful effects on the cardiovascular system. According to obtained results chocolate consumption will reduce both systolic and diastolic blood pressure. In general, drinking coffee causes increased blood pressure, irregular heartbeat, increased blood cholesterol, increased levels of homocysteine and increased risk of heart attacks. Several studies indicated fetal cardiac arrhythmias caused by excessive consumption of caffeine in pregnant women.Conclusions: According to the results, green and black tea has no harmful effects on cardiovascular diseases, but in some cases positive effects have also been reported. Consumption of chocolate, cocoa and coffee have harmful effects on the cardiovascular system. Due to the effects of caffeine on pregnant women, consumption of coffee and caffeine should be reduced during pregnancy. Manuscript profile -
Open Access Article
4 - Determination of caffeine content in Wollega Zones, Ethiopian coffee bean, pulp and leaves by high performance liquid chromatography
Zerihun Asfew Aman Dekebo -
Open Access Article
5 - media conditioning on the antioxidant and histomorphometry of testis following caffeine consumption in adult male rat
Davoud Rahimi Jabbar Bashiri Alireza NoorAzar رقیه Pouzesh Jadidi Daryoush MohajeriConsidering the consumption of caffeine as a supplement favored by theathletes and the proof of its long-term abuse effects on male fertility, the purpose of this study was to investigate the effect of moderate aerobic training combined with the conditioning of Sertoli MoreConsidering the consumption of caffeine as a supplement favored by theathletes and the proof of its long-term abuse effects on male fertility, the purpose of this study was to investigate the effect of moderate aerobic training combined with the conditioning of Sertoli cell media in testicular damage caused by caffeine consumption.For this purpose,30male Wistar rats were tested in5groups.For4weeks, the groups received caffeine at a dose of200 mg/kg orally and group1received of distilled water.42days after that, the conditioned media of Sertoli cells was injected into the efferent ducts of the rats in the treatment group.After8 weeks, mice were sampled.Tissue samples were studied by histomorphometry andSOD,,GPX, TACand MDA.The group under the influence of caffeine compared to the healthy group, significantly(p<0.01).had lower values of seminiferous tubule diameter, epithelium height, interstitial thickness,TAC, SODandGPXand higher values ofMDA. Respectively, the three groups affected by caffeine along with exercise treatment, treatment with media conditioning and exercise along with media conditioning compared to the group affected with caffeine, have higher values of seminiferous tubule diameter, epithelium height, interstitial thickness,TAC, SODandGPX,and MDA values were lower.In the treatment group with media conditioning and exercise, there was a significant difference in the amount of decrease and increase in the mentioned parameters compared to the other two treatment groups (p<0.05).The results of the present study showed that the use of Sertoli cell media conditioning and aerobic exercise at the same time, with synergistic effects, improves the antioxidant defense indices and reduces the harmful effects of caffeine in the testicular tissue of rats.. Manuscript profile -
Open Access Article
6 - Caffeine-loaded Fe3O4 nanoparticles: A new magnetically recoverable organocatalyst for Knoevenagel condensation reaction
Soheil Sayyahi -
Open Access Article
7 - Exploration of the adsorption of caffeine molecule on the TiO2 nanostructures: A density functional theory study
Amirali Abbasi -
Open Access Article
8 - Caffeine-loaded Fe3O4 nanoparticles: A new magnetically recoverable organocatalyst for Knoevenagel condensation reaction
Mina Javdannezhad Maryam Gorjizadeh Mohammad Hosein Sayahi Soheil Sayyahi -
Open Access Article
9 - Effect of combined consumption of caffeine and carbohydrate on anaerobic performance and muscular strength of young male soccer players
Elham Farhadfar Seyed Mohammad Hosseini AraThe purpose of this study was the effect of combined consumption of caffeine and carbohydrate on anaerobic performance and muscle strength of young male soccer players12 young male athletes in 20-25 years volunteered. In the carbohydrate turn, 21 grams of carbohydrate s MoreThe purpose of this study was the effect of combined consumption of caffeine and carbohydrate on anaerobic performance and muscle strength of young male soccer players12 young male athletes in 20-25 years volunteered. In the carbohydrate turn, 21 grams of carbohydrate supplement dissolved in 250 ml of water along with flavoring and food coloring was consumed 30 minutes before the test. caffeine supplement of 6 mg per kilogram of body weight was consumed as a solution in 250 ml of water. In the turn of combined consumption of supplements, the subjects consumed caffeine and carbohydrates. In the placebo group, 250 ml of water was consumed along with flavoring and food coloring. 48 hours after the last consumption, the tests were repeated. The Shapiro-Wilk test was used to determine the normal distribution of the data and to compare the results of the groups, the analysis of variance with repeated measurements and the Makhli test were used. the significance level of the tests was p≥0.05.The results showed that the average anaerobic power of the subjects in the caffeine + carbohydrate group was about 15% higher than placebo and 13% higher than carbohydrate. The average strength of the lower body and upper body of the subjects in caffeine + carbohydrate was 12 and 18% higher than placebo and 9 and 15% higher than carbohydrate. Also, the consumption of caffeine, carbohydrates and the combination of these two had no effect on the fatigue index. Manuscript profile -
Open Access Article
10 - Synthesis of pyrazolopyranopyrimidines catalyzed by caffeine supported on boehmite nanoparticles and their evaluation for anti-bacterial activities
Mohammad Bakherad Rahele Doosti Mahdi Mirzaee Khosrow Jadidi -
Open Access Article
11 - Caffeine effect on adenosine deaminase catalysis: A new look at the effect of caffeine on adenosine deaminase activity
Roya Mahinpour Majid Ghasemi Zahra Moosavi-Nejad Zohreh Zahraie -
Open Access Article
12 - Effect of Caffeine-based Energy Drinks on Perceived Exertion and Mood of Basketball Players Aged 16 to 18 Years
pezhman ahmadi vahid farahani bita divsarnazIn recent years the consumption of energy drinks has increased dramatically, especially among athletes. Athletes believe that consuming energy drinks increases their performance due to their ergogenic compounds such as sugars, caffeine and taurine. The age range was 16 MoreIn recent years the consumption of energy drinks has increased dramatically, especially among athletes. Athletes believe that consuming energy drinks increases their performance due to their ergogenic compounds such as sugars, caffeine and taurine. The age range was 16 to 18 years. The statistical population of the study was 60 male high school students in the third grade of the Malard School of Physical Education, out of which 24 volunteers with the same weight (between 68 and 72 kg) were selected. Participants were randomly assigned to three groups: consumption of 250 ml hype drinks with caffeine (32 mg per 100 ml), placebo and baseline conditions. Interventions were applied for 3 weeks. In the present study, Wall Sit test was used for fatigue. Then, perception of stress through Borg index and mood status was assessed by Broms Questionnaire in two stages of pretest and posttest. The results of Friedman test and repeated analysis of variance showed that consumption of hype drinks significantly reduced perception of stress and temperament in adolescent basketball players. As a result, energy drink hype can be effective in reducing perception of stress and improving mood in adolescent basketball players. The present study also showed that perception of placebo (effect of placebo) can be effective in reducing perception of stress and mood. Manuscript profile
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