List of Articles هیپرلیپیدمی

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  1 - Histopathological comparison of the effect of Salvia sharifi and Salvia virgata extracts on hyperlipidemia in adult male rat
  Shahraki Mojahed, L., Davari, S.A.*, Hajinezhad, M.R. .
  This study was aimed to compare the effects of Salvia Sharifi and Salvia Virgata on serum lipids and histopathology of liver in hyperlipidemic rats. Forty male adult Wistar rats were distributed into four groups as follow: (1) control, (2) hyperlipidemic rats, (3) hyper More

  This study was aimed to compare the effects of Salvia Sharifi and Salvia Virgata on serum lipids and histopathology of liver in hyperlipidemic rats. Forty male adult Wistar rats were distributed into four groups as follow: (1) control, (2) hyperlipidemic rats, (3) hyperlipidemic rats received hydroalcoholic extract of S. Virgata (200 mg/kg bw) and (4) hyperlipidemic rats received hydroalcoholic extract of S. Sharifi (200 mg/kg bw). A high-fat diet was administered to rats for one month.Then, two rats were selected from each diet group and hyperlipidemia was confirmed by measurement of serum triglyceride and serum cholesterol levels. Groups 3&4 were orally treated by S. Virgata and S. Sharifi respectively for 21 days. At the end of the experiment, blood samples were obtained by heart puncture and used to determine serum triglyceride, cholesterol, HDL and LDL levels and liver specimens were obtained for histopathological investigations. The data were analyzed by one-way ANOVA and Tukey's post hoc test. The results showed that S. Sharifi extract significantly reduced serum triglyceride, cholesterol and LDL levels and increased serum HDL compared to untreated hyperlipidemic rats. Treatment with S. Virgata reduced serum triglyceride, cholesterol and LDL levels but serum HDL of rats in this group had no significant effect in comparison to hyperlipidemic group. In addition, S. Sharifi extract decreased hepatic lesions in comparison to hyperlipidemic rats received S. virgata. These results showed the protective effect of S. Sharifi and S. Virgata extracts on hyperlipidemia-induced liver injury and this protection was more pronounced in the group received S. Sharifi. Manuscript profile
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  2 - Hypolipidemic effect of dill essential oil in hyperlipidemic rats
  Tayebeh Moradkhani Maryam Eidi Alireza Saeedinia
  Hyperlipidemia is one of the most important risk factors of cardiovascular disease. The aim of present study was to evaluate the effect of essential oil dill on the lipid profile in hyperlipidemic rats. Thirty-six adult male rats were divided into 6 groups including nor More

  Hyperlipidemia is one of the most important risk factors of cardiovascular disease. The aim of present study was to evaluate the effect of essential oil dill on the lipid profile in hyperlipidemic rats. Thirty-six adult male rats were divided into 6 groups including normal group, control hyperlipidemic group (received 10% lipid in food), hyperlipidemic rats (received atorvastatin at dose of 10 mg/kg, daily) and experimental hyperlipidemic rats (received essential oil of dill at doses 0.5, 1 and 2 ml/kg, daily). After 8 weeks and 12 h fastening, the animals were weighted and anesthetized by ether. The blood and liver sampling was done. The serum cholesterol, triglyceride, LDL, HDL, VLDL, AST and ALT levels were measured by kit. The liver sections were stained by haematocilin-eosin method. The result showed that oral treatment of atorvastatin and essential oil of dill decreased weight gain, serum cholesterol, triglyceride, LDL, VLDL, AST and ALT levels and liver damaged, while increased serum HDL level in experimental rats in comparison to control hyperlipidemic rats, significantly. So, essential oil of dill improved lipid profile in hyperlipidemic animal and has antioxidant effect with improving liver tissue and function. Manuscript profile
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  3 - Hypolipidemic effect of fenugreek (Trigonella foenum-graecum L.) on serum lipid profile and PPAR-gamma gene expression in adipose tissue of hyperlipidemic male rats
  Maryam Eidi Mahdieh Mohseni
  10.30495/jdb.2022.1964609.1325
  Hyperlipidemia is one of the most important risk factors of cardiovascular disease. The aim of present study was to evaluate the effect of hydro-methanolic extract of fenugreek on the serum lipids and PPAR-gamma gene expression in the adipose tissue of hyperlipidemic ra More

  Hyperlipidemia is one of the most important risk factors of cardiovascular disease. The aim of present study was to evaluate the effect of hydro-methanolic extract of fenugreek on the serum lipids and PPAR-gamma gene expression in the adipose tissue of hyperlipidemic rats. Thirty-six adult male rats randomly were divided into 6 groups including normal group, control hyperlipidemic group (received 10% lipid in food), positive control hyperlipidemic rats (received atorvastatin at dose of 10 mg/kg, daily) and experimental hyperlipidemic rats (received extract at doses 100, 200 and 400 mg/kg, daily). After 8 weeks and 12 h fastening, the animals were weighted and anesthetized by ether. The liver was removed and weighted. The blood and adipose tissue sampling were done. The weight gain, liver index, serum cholesterol, triglyceride, LDL, HDL, AST and ALT levels were measured by kit and PPAR-gamma gene expression in the adipose tissue was evaluated by real-time PCR. The results showed that oral treatment of atorvastatin and extract of fenugreek decreased weight gain, serum cholesterol, triglyceride, LDL, AST and ALT levels and PPAR-gamma gene expression in adipose tissue, while increased serum HDL level in experimental hyperlipidemic rats compared to control hyperlipidemic rats, significantly. So, the extract of fenugreek improved lipid profile and then down-regulated PPAR-gamma gene expression in adipose tissue. Manuscript profile
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  4 - The Effects of Soy Milk on Serum Lipid Profile in Hyperlipidemia Menopause Women in Shiraz
  خاطره صفوی نائینی
  Cardiovascular disease is related with various risk factors. The most important of these are age. Coronary arterial disease mortality is increased after menopause. It is due to hypoestrogenemia. Soy bean is a source of fetoestrogen that is similar to hormone. The most i More

  Cardiovascular disease is related with various risk factors. The most important of these are age. Coronary arterial disease mortality is increased after menopause. It is due to hypoestrogenemia. Soy bean is a source of fetoestrogen that is similar to hormone. The most important fetoestrogen is isoflavone. Soy bean is source of isoflavone that can decrease serum total cholesterol so protect of heart disease.In this randomized clinical trial 50 menopause women with hyper lipidemia and inclusion criteria were chosen. They were divided randomly to two groups (control and soya milk) diet. In soya milk group they were given 1 liter soya milk every day for 12 weeks. In control group they were not given soya milk or any product of soya. Initial and after 12weeks they were assayed for serum lipids profile. Data were collected and analyzed by SPSS software. There were no significant changes in serum lipids profile (triglyceride, HDL-cholesterol, LDL-cholesterol, total cholesterol) within control group Initial and after 12 weeks (P=NS). There were no significant changes in serum lipids profile) triglyceride, HDL-cholesterol, LDL-cholesterol, total cholesterol) within soya milk group Initial and after 12 weeks (P=NS). There were no significant changes in serum lipids profile) triglyceride, HDL-cholesterol, LDL-cholesterol, total cholesterol)between soya milk group and control group Initial and after 12weeks (P=NS).It seems soy milk has no actually effects on serum lipids profile, therefore this subject need to additional studies. Manuscript profile
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  5 - Evaluation of hyperlipidemia in patient with hypertension refered to hospitals of Azad university of Mashhad in 86-87
  Mahdi Masumian Mohamad Sarafraz yazdi Golnoosh Ghooshchi
  Aims: About a quarter of adult people (60 million in USA and 1 billion all over the world) suffer arterial blood pressure. Hypertension is the main reason of mortality around the world and is a big trouble in public health. Whereas the lipids such as total cholesterol, More

  Aims: About a quarter of adult people (60 million in USA and 1 billion all over the world) suffer arterial blood pressure. Hypertension is the main reason of mortality around the world and is a big trouble in public health. Whereas the lipids such as total cholesterol, triglyceride, HDL and LDL concern in atherosclerosis which are followed by cardiovascular disorders, we conducted to evaluation of hyperlipidemia in the high arterial blood pressure patients. Method: We carried out our thesis by observational case-control method and we studied 400 patients who refer to the cardiac and internal clinics of Azad University Hospitals of Mashhad during 2007-2008. We divided the patients to 2 groups: 200 patients for control (with normal blood pressure) and 200 patients for case group (high blood pressure). We recorded clinical and demographic information by a questionnaire and then a lipid profile test (cholesterol, triglyceride, HDL and LDL) was done. Results: According to the results there is a significant difference in the levels of total cholesterol and triglyceride between 2 groups (Pvalue= 0.0001). But there is not a significant difference for HDL (Pvalue= 0.692).A bout LDL there is a significant difference between 2 groups. (Pvalue= 0.001). Due to ‍confounding factors such as age, occupation and etc there is no significant difference in a multi-variable logistic regression model in all lipids except triglyceride between 2 groups.(total cholesterol (Pvalue= 0.240), triglyceride (Pvalue= 0.027) , LDL(Pvalue= 0.249), HDL (Pvalue= 0.906)). Discussion: Statistical results showed that there is a significant relation between hypertrigliceridemia and hypertension, but other lipids with notice to confounding factors need to accompariment other risk factors until can be predisposal factors for hypertension.   Manuscript profile