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      • Open Access Article

        1 - Evaluation of the Effect of Polyethylene Coating Based on Silver Nanoparticles on Increasing the Shelf Life, Qualitative and Microbial Parameters of Wheat Germ
        M. Darab Sh. Shahriari H. Mozafari
        Introduction: It is possible to increase the shelf life and maintain the quality of wheat germ during storage by using suitable packaging. One of the new technologies considered by researchers is the use of packaging based on nanoparticles.Materials and Methods: In this More
        Introduction: It is possible to increase the shelf life and maintain the quality of wheat germ during storage by using suitable packaging. One of the new technologies considered by researchers is the use of packaging based on nanoparticles.Materials and Methods: In this study, wheat germs were packaged in polyethylene packages containing silver nanoparticles, and the effect of the packaging on the quality characteristics and shelf life of wheat germ were determined. In this research work, at determining the most optimal conditions for the packaging of wheat germ, the effects of weight percent (wt%) of nanosilver (0, 3, and 5%), time of storage (0, 5, and 10 days), and three different temperatures (2, 4, and 6 0C) on the shelf life of wheat germ have been studied.Results: The results showed that temperature, storage time, and concentration of nanosilver in polyethylene packaging had significant effects on moisture, pH, and enzyme activity of wheat germ. Experimental data indicated that the storage time of wheat germ increased by increasing the concentration of nanosilver from 3% to 5% and by decreasing temperature from 6 ° C to 2 ° C for ten days. Nanoparticle packages were significantly (P <0.05) able to reduce mold growth in wheat germ.Conclusion: Based on the results, it might be concluded that the application of films based on silver nanoparticles increases the shelf life of wheat germ. Wheat germ had the highest shelf life in packaging with 5% silver nanoparticles at 2 ° C and was selected as the selected sample. Manuscript profile
      • Open Access Article

        2 - Synergic effects of scopoletine and green synthesized silver nanoparticles on Angiogenesis of Chick Chorioallantoic Membrane (CAM)
        Parisa zamani esmati Javad Baharara Alireza Iranbakhsh Tayebeh Ramezani
        Background: Today, anti-angiogenesis properties of plants products are considered by researchers. Since the silver nanoparticles (AgNPs) are green synthesized and scopoletine, have anti-angiogenesis properties. In the present study, the use of these two substances has b More
        Background: Today, anti-angiogenesis properties of plants products are considered by researchers. Since the silver nanoparticles (AgNPs) are green synthesized and scopoletine, have anti-angiogenesis properties. In the present study, the use of these two substances has been investigated on the angiogenesis in the Chick Chorioalantoic Membrane. Materials and Methods: In this experimental study, the fertilized eggs were divided, the control and experimental groups including silver nanoparticles treated with nanoparticles (50, 100 and 150 μg/ml), scopoletine (25, 50 and 100 μg/ml), synergistic group, 50μg ml silver nanoparticles and 25 μg/ml scopoletin. In 8th day incubation, treatment was done on gelatin sponge and in 12th day were photographed and the number and lengths of vessels around the sponges, crown rump (CR), fetal weight and blood vessels hemoglobin levels were recorded and compared with control. Data were analyzed by SPSS-16 software, one way ANOVA and Tukey test in significant level of P <0.05. Results: The results showed that dose dependent manner of silver nano particles and scopolotine reduced the number and length of blood vessels and decreased level of hemoglobin concentration in treatment groups. The use of Synergic 50 μg/ml nanoparticles and 25 μg/ml concentration of scopoletine, which did not affect on the angiogenesis process, showed a significant decrease in angiogenesis (P<0.05). Conclusion: The use of green synthesized silver nanoparticles and scopolinoth has been shown to enhance their anti-angiogenic effects and can be considered as an important study basis to identify effective therapeutic strategis. Manuscript profile
      • Open Access Article

        3 - Histopathology and Anti-cancer Effects of Silver Nanoparticles on the Gelatin Substrate in Ovarian Cancer Induced by DMBA in Female Wistar Rats
        عباسعلی دهپور جویباری مستانه میرمیرانی سیده مرضیه محمدی مرجان فرهمند
        Ovarian cancer is one of the commonest cancers among the woman. Although not common, but one of the main causes of death in woman is considered.one of the main problem in the treatment of cancer is the lack of active drugs and effective drugs, and drug resistance to the More
        Ovarian cancer is one of the commonest cancers among the woman. Although not common, but one of the main causes of death in woman is considered.one of the main problem in the treatment of cancer is the lack of active drugs and effective drugs, and drug resistance to the drugs available. Nanoparticles are one of the most well-known nanomaterials that have been studied for their anticancer properties. Among these nanoparticles, silver nanoparticles having very strong antimicrobial properties in medical and dental acceptility are high. Thus, the present study was carried out to study the cytotoxic effects of silver nanoparticles on the glycine substrate on ovarian cancer induced by DMBA in female wistar rats. In this study, female wistar rats were used .Animals were divided into 6 groups. The first group was the control group. The second group only injected by DMBA respectively. Third group treated with injection of DMBA+Salin and other groups treated injection of different doses of silver nanoparticles on the glycine substrates to induced cancer,7,12 dimethyl benza anthracen was directly injected in to ovary. In this study the weight of ovaries and ovarian histopathological features in all experimental groups were measured and evaluated and finally, data collected using 16 spss software and one way ANOVA were analyzed. The tumor weight in the group receiving the nanoparticle fell sharply. In fact, the silver nanoparticles were significantly positive effects on cancer cells. The microscopic section of luteinizing and follicle improved in the group receiving the silver nanoparticles on the glycine substrate was observed. This study confirms the positive effect of the silver nanoparticle on glycine substrate in treating the ovary cancer and destroying cancer cells, although more studies are needed. Manuscript profile