Histopathology and Anti-cancer Effects of Silver Nanoparticles on the Gelatin Substrate in Ovarian Cancer Induced by DMBA in Female Wistar Rats
Subject Areas : Journal of Animal Biologyعباسعلی دهپور جویباری 1 , مستانه میرمیرانی 2 , سیده مرضیه محمدی 3 , مرجان فرهمند 4
1 - گروه زیست شناسی، واحد قائمشهر، دانشگاه آزاد اسلامی، قائمشهر، ایران
2 - گروه زیست شناسی، واحد قائمشهر، دانشگاه آزاد اسلامی، قائمشهر، ایران
3 - گروه زیست شناسی، واحد قائمشهر، دانشگاه آزاد اسلامی، قائمشهر، ایران
4 - گروه زیست شناسی، واحد قائمشهر، دانشگاه آزاد اسلامی، قائمشهر، ایران
Keywords: Rat, silver nanoparticle, DMBA, Ovarian cancer,
Abstract :
Ovarian cancer is one of the commonest cancers among the woman. Although not common, but one of the main causes of death in woman is considered.one of the main problem in the treatment of cancer is the lack of active drugs and effective drugs, and drug resistance to the drugs available. Nanoparticles are one of the most well-known nanomaterials that have been studied for their anticancer properties. Among these nanoparticles, silver nanoparticles having very strong antimicrobial properties in medical and dental acceptility are high. Thus, the present study was carried out to study the cytotoxic effects of silver nanoparticles on the glycine substrate on ovarian cancer induced by DMBA in female wistar rats. In this study, female wistar rats were used .Animals were divided into 6 groups. The first group was the control group. The second group only injected by DMBA respectively. Third group treated with injection of DMBA+Salin and other groups treated injection of different doses of silver nanoparticles on the glycine substrates to induced cancer,7,12 dimethyl benza anthracen was directly injected in to ovary. In this study the weight of ovaries and ovarian histopathological features in all experimental groups were measured and evaluated and finally, data collected using 16 spss software and one way ANOVA were analyzed. The tumor weight in the group receiving the nanoparticle fell sharply. In fact, the silver nanoparticles were significantly positive effects on cancer cells. The microscopic section of luteinizing and follicle improved in the group receiving the silver nanoparticles on the glycine substrate was observed. This study confirms the positive effect of the silver nanoparticle on glycine substrate in treating the ovary cancer and destroying cancer cells, although more studies are needed.
