Introduction: Gold nanoparticles can be used as a protective compound in the packaging of nutritionally valuable materials due to their non-toxic effects on humans and high antibacterial and antioxidant properties. Other applications in the food industry, such as the co More
Introduction: Gold nanoparticles can be used as a protective compound in the packaging of nutritionally valuable materials due to their non-toxic effects on humans and high antibacterial and antioxidant properties. Other applications in the food industry, such as the construction of sensors to identify the remnants of hazardous materials from agricultural and industrial processes, are conceivable for these materials. One of the methods of synthesis of these nanoparticles is the use of natural compounds due to reducing the side effects of chemicals, a new approach that in recent years has been referred to as "green chemistry".Materials and Methods: gold nanoparticles were synthesized using curcumin purified from turmeric as the main source of this compound. The synthesis process was investigated using UV-VIS, FT-IR spectroscopy methods. The structure and morphology of the nanoparticles were performed using XRD spectroscopy and TEM and SEM imaging. The antioxidant properties of gold-curcumin nanoparticles were evaluated by DPPH free radical scavenging method.Results: Au-nanoparticles were synthesized using the green chemistry method using curcumin purified from turmeric in the form of a cross and cubic crystal structure of filled funds with an average size of 9.80 nm. Antioxidant studies showed that the free radical scavenging ability of gold-curcumin nanoparticles was increased as compared to pure curcumin.Conclusion: Curcumin as a natural compound with antioxidant properties has the ability to reduce gold ions and convert them into nanoparticles, and due to the use of these nanoparticles in the food industry, this method can be used as a green, inexpensive and eco-friendly.
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Background & Objectives: Escherichia coli is an important indicator in the quality control of pharmaceutical and real samples. This study compares the detection of this bacterium by regular method and a biosensor based on Multi-Walled Carbon Nanotubes (MWCNTs) on glassy More
Background & Objectives: Escherichia coli is an important indicator in the quality control of pharmaceutical and real samples. This study compares the detection of this bacterium by regular method and a biosensor based on Multi-Walled Carbon Nanotubes (MWCNTs) on glassy carbon electrodes (GCE) in pharmaceutical and water as real sample.
Materials and Methods: In this experimental study, the conventional culture method (pour plate) and modified biosensor based on Multi-Walled Carbon Nanotubes on glassy carbon electrode with the arrangement of GC/MWCNTs/AuNPs/Ab/BSA were used for the detection of E. coli. Dilutions of E. coli between (1 ×101–1×108 CFU/ml) were used in pharmaceutical and water samples, prepared in 0.1 M PBS (pH 7.4), mixed with 0.5mM acetaminophen. The efficiency of the designed biosensor was investigated using SEM, Cyclic Voltammetry, and Square-Wave Voltammetry electrochemical techniques, as well as interfering bacteria.
Results: The results of E. coli detection using the conventional culture and designed biosensor were not statistically significant. The designed biosensor had a high sensitivity with accuracy in 3 minutes and LOD 3.02 CFU/ml for Escherichia coli.
Conclusion: Considering the time-consuming and influenced by environmental factors in the microbial monitoring of pharmaceuticals for E. coli detection in conventional methods and the risk of losing pharmaceutical products, the biosensor has good efficiency in detection with low cost and no need for enrichment in a small volume of samples.
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Since ancient times, gold has been prescribed by old doctors as food and medicine for cure of many illnesses like fear and stress. The purpose of this research is studying of the impression of inter ventricle- brain injection gold Nano-particles on the number of lobules More
Since ancient times, gold has been prescribed by old doctors as food and medicine for cure of many illnesses like fear and stress. The purpose of this research is studying of the impression of inter ventricle- brain injection gold Nano-particles on the number of lobules and alveoli and epithelial cells in breast glands at female rotes after childbirth.Control groups for each period instead of gold nano-particles, received distilled water. After surgery, the rats were killed at the end of perfusion and brain was removed from the skull and they were removed from the skull and brains were stored in 10% formalin for 48 hours. Then 4andmu;m sections were prepared from frozen brains and the process of cutting and preparation of slides and stained slides were counted by the gratitude. In this research, the site of ventricle was indicated by using of Parkinson atlas and by stereo tax system a case study mice and guidance canals exactly installed on the same site. Nano-particle was injector to ventricle at amounts 1, 5 and 10 andmicro;g/ kg. Histological study of actual lobules and alveoli is performed at breast glands of animal 24, 48 and 72 hours after injection. Histological study of the breast glands shows that the injection of gold nano-particle at doses 1 andmicro;g/kg and 5 andmicro;g/kg increase the number of epithelial and alloys of breast glands at desert female mouse race of instar. But close 10andmicro;g/kg isnandrsquo;t such impressions.The results show that repeated doses of injected particles at various doses was effective in effect. Nano-particles of gold could act as a competitive antagonist of dopamine and dopamine receptor blocking effect on the release of dopamine effect on and inhibition of prolactin secretion is increased. PRL negative feedback on the hypothalamus of the way and reduce their secretion, which is a type of inhibition for each drug or increasing milk Probably one of the reasons that a dose of 10 micrograms per kilogram of gold nano-particles worked, so the effect of a negative feedback of prolactin on hypothalamic axis - the pituitary has been. The number of alveoli affected by the gold nano-particles with different doses compared to the control group and the dose was ineffective in some.
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