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Open Access Article
1 - Synthesis and Physico-mechanical Characterization of β-tricalcium Phosphate-Hydroxyapatite-Bioactive Glass Composite for Use in Bone Tissues Regeneration
S.K. Seyedmajidi F. Moztarzadeh M. Seyedmajidi S.A. Seyedmajidi -
Open Access Article
2 - Preparation of Fluorapatite Nanoparticles and 45S5 Bioactive Glass by Sol-gel Method
S.A. Manafi F. Mirjalili R. Rashidi -
Open Access Article
3 - Evaluation of Bioactivity, Antibacterial and Cell Viability Properties of Electrophoretic Coated Bioglass- Silver Nano Composite on Ti-6Al-4V
M. Talepour Ardakani S.A. Hassanzadeh Tabrizi -
Open Access Article
4 - Bio-active Glass Synthesis by Sol-gel Process and using Spark Plasma Sintering for Forming Process
S.A. Manafi M. Mohsenpour-Tehrani -
Open Access Article
5 - Characterization and investigation of biocompatibility of bioactive glass 60 mol%SiO2-36 mol%CaO-4 mol%P2O5-5 mol%SrO containing zinc
Amirhossein Moghanian Noushin Nankali Morteza SaghafiyazdiIn this research, bioactive glasses 60mol%SiO2-36mol%CaO-4mol%P2O5-5mol%SrO containing 0, 5, and 8 mol% zinc were synthesized by sol-gel method, and the effect of adding ZnO microstructure, in vitro bioactivity and biocompatibility was investigated. To investigate the i MoreIn this research, bioactive glasses 60mol%SiO2-36mol%CaO-4mol%P2O5-5mol%SrO containing 0, 5, and 8 mol% zinc were synthesized by sol-gel method, and the effect of adding ZnO microstructure, in vitro bioactivity and biocompatibility was investigated. To investigate the in vitro bioactivity, glass powders were placed in the simulated body solution (SBF) for 14 days, and before and after the mentioned periods, the changes and process of hydroxyapatite (HA) phase formation on BGs surfaces, using characterization methods. Fourier transform infrared (FTIR), checking the release rate of different ions by inductively coupled plasma spectroscopy (ICP_AES), pH changes, and microstructure studies using a scanning electron microscope (SEM) were investigated. In the infrared Fourier transform spectroscopic analysis of the surface of the synthesized bioactive glasses after immersion in SBF solution, phosphate and carbonate bands were detected, indicating the synthesized glasses' bioactivity. Also, the scanning electron microscope images showed that the microstructure of HA created was spherical. Finally, among all the bioactive glasses synthesized in this research, S5Z5 bioactive glass was introduced as a new multi-functional biological bio-material in bone tissue engineering due to its osteogenic, biocompatibility, and bioactivity in vitro properties. Manuscript profile -
Open Access Article
6 - Evaluation of the Potential of 3D Printed Polycaprolactone Scaffolds Coated with Bioceramics in the Proliferation and Osteogenic Differentiation of Human Adipose Tissue-derived Mesenchymal Stem Cells
Nasrin Fazeli Ehsan Arefian Shiva Irani Abdolreza Ardeshirylajimi Ehsan SeyedjafariIn recent years, the focus of researches in the field of tissue engineering has been on the preparation of scaffold materials and methods. 3D printing is an emerging technology that can accurately and quickly prepare bone tissue engineering scaffolds with specific shape MoreIn recent years, the focus of researches in the field of tissue engineering has been on the preparation of scaffold materials and methods. 3D printing is an emerging technology that can accurately and quickly prepare bone tissue engineering scaffolds with specific shapes and structures. One of the most common 3D printing methods is fused deposition modeling (FDM), the materials used in this method are polymers such as polycaprolactone (PCL). In this study, 3D printed PCL scaffolds were made and due to the hydrophobic and non-osteogenic nature of PCL, the surface of the scaffolds was coated with a 1% solution of hydroxyapatite (HA) and bioactive glass (BG) bioceramics. Surface modification of PCL scaffolds was done to increase hydrophilicity and improve cell attachment. Field emission scanning electron microscop (FeSEM) images, Energy-dispersive X-ray spectroscopy (EDS) and mapping of the surface elements of the scaffolds confirmed the proper coating of PCL scaffolds with HA and BG bioceramics. The biocompatibility of PCL/HA/BG scaffolds and the cell viability and attachment on the surface of the scaffolds were investigated by seeding of human adipose mesenchymal stem cells (hAMSCs) and using MTT test and FeSEM images. Also, the potential of PCL/HA/BG scaffolds in osteogenic differentiation of hAMSCs was evaluated by alkaline phosphatase activity measurement test and immunocytochemical staining. The results showed that the three-component PCL/HA/BG scaffolds improved the proliferation and osteogenic differentiation of hAMSCs, so the PCL/HA/BG scaffolds can be a suitable candidate for bone tissue engineering applications. Manuscript profile