The effect of edible mushroom vinegar (Agaricus bisporus) on fat metabolism in obese rats caused by overeating
Subject Areas : biotechnology
farhang moraghebi
1
(Graduated from Department of Convergent Sciences and Techniques Faculty of Basic Sciences Central Tehran Branch, Islamic Azad university.Tahran. Iran)
Hamid Reza Samadikhah
2
(Department of Convergent Sciences and Techniques Faculty of Basic Sciences Central Tehran Branch, Islamic Azad university.Tahran. Iran)
Keywords: Obesity, Wistar Rat, PPAR gene, GLUT4 gene, Adiponectin gene, LPL gene,
Abstract :
Abstract Introduction:Fat is one of the most important components of human diet. The human body needs fats to perform its daily activities. In case of eating a lot of carbohydrates, inactivity or genetic factors, some people have obesity problem. Obesity and overweight are relatively dangerous diseases. The production of vinegar from various materials has been of interest for a long time, and it is used as an effective drink for weight loss. The purpose of this research is to investigate the effect of vinegar prepared from button mushrooms on obesity. Methods: 12 eight-week-old male Wistar rats became obese during 4 weeks with high feeding and low exercise. The effect of edible mushroom vinegar during 2 weeks on obesity with three treatments (control group (VS) boiled vinegar group ml2 (V1), boiled vinegar group ml 1 (V2) and raw vinegar group ml 2 (V3) per kilogram of weight) was investigated. Vinegar treatment was directly entered into the stomach of rats with the help of long gavage needles. Results: All treatments caused significant (p<0.01) weight loss. A number of genes effective in the production of fat in the liver were investigated. Increasing GLUT4 gene expression was effective in preventing lipogenesis in all treatments of obese rats with overeating. The increase in PPAR gene expression was not significant. Increasing the expression of Adiponectin gene was effective in increasing lipolysis in all treatments of obese rats with overeating, While the increase in LPL gene expression was not significant. All 3 mushroom vinegar treatments had a positive effect on the reduction of renal enzymes ALT and ALP. V2 treatment of mushroom vinegar reduced cholesterol and triglycerides. Discussion: It was found that edible mushroom vinegar causes weight loss and also has positive protective effects on the liver.
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