The Study of Herpes Simplex 1 and 2 and Cytomegalovirus Viruses in Patients with Alzheimer Disease

Subject Areas : microbiology

Sepideh Khodamoradi ¹ , Mohammad Hassan Shahhosseiny ² , Taher Mohammadian ³ , Atousa Ferdousi ⁴

1 - PhD. Candidate of Microbiology, Department Of Microbiology, Shahr-e-Qods Branch- Islamic Azad University, Tehran, Iran
2 - Professor, Department Of Microbiology, Faculty of Basic Sciences, Shahr-e-Qods Branch-Islamic Azad University, Tehran, Iran
3 - Assistant professor, Department Of Microbiology, Faculty of Basic Sciences, Shahr-e-Qods Branch-Islamic Azad University, Tehran, Iran
4 - Assistant professor, Department Of Microbiology, Faculty of Basic Sciences, Shahr-e-Qods Branch-Islamic Azad University, Tehran, Iran

Received: 2020-12-06 Accepted : 2021-01-08 Published : 2020-02-20

Keywords: Prevalence, Alzheimer, Cytomegalovirus, Herpes virus,

Abstract :

Different environmental factors, such as infection have cause Alzheimer's disease. Studies have shown that Herpes simplex 1 and 2 and cytomegalovirus viruses have relations with Alzheimer disease. Human cytomegalovirus viruses (CMV) induces infection in central nervous system. It is need a study investigating the relation between different viruses with Alzheimer. The current study, investigates the relation between different viruses Alzheimer. In this study, 100 patients with Alzheimer were studied and blood samples were collected (1.5 ml per patient). Following extraction of viral DNA, the samples were investigated by PCR method. The data for peoples with positive PCR were analyzed by Kruska-Walis test of SPSS software (version 23). The prevalence of CMV, HSV2 and HSV1 was observed in 27, 8 and 4 people that means 27%, 8% and 4%. These results suggest that CMV infection is associated to increased risk of AD and a quick rate of cognitive decline in elderly populations. In sum, all the studied viruses were identified, but cytomegalovirus virus had higher frequency.