Prophylactic effects of Dexamethasone on Xylazine –Induced Vomiting in Dogs and Comparison with Metoclopramide

Subject Areas : Journal of Large Animal Clinical Science Research(JLACSR)

Received: 2021-07-06 Accepted : 2021-07-06 Published : 2007-09-23

Keywords: dogs, dexamethasone, Vomiting, Metoclopramide, Xylazine Hydrochloride,

Abstract :

Xylazine Hcl was enthusiastically received as a sedative and over the past 30 years it has maintained its popularity as a generally reliable sedative and premedication in a wide range of animal species, especially in dog and cats. One of the side-effects of Xylazine consists of vomiting at the onset of sedation that sometimes necessitates using antemetic drugs. In this study six healthy dogs (3 male and 3 female) with 163.41 Kg B.W, and 3.32 years old were exploited for 3 weeks. In the first week, effect of (4 mg/BW, IM) of dexamethasone injection, 30 min prior to administering xylazine Hcl(1 mg/kg ,IM) was studied. In the second week, effect of 0.4 mg/kg IM metoclopramide injection, 30 min before using xylazine Hcl was studied. In the third week, effect of normal saline IM injection with same volum as dexamethasone, 30 min before using xylazine Hcl was studied. Results showed that dexamethasone could prevent xylazine -induced emesis in dogs and its effect was similar to metoclopramide effects. Thus, it was concluded that dexamethasone can be used as a prophylactic antiemetic drug in dogs sedated with xylazine hydrochloride.

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