The Effect of Olibanum Extract with Aerobic Exercise Training on Cognitive Status and Serum BDNF Levels in the Elderly with Mild Cognitive Impairment
Subject Areas : Open Access
zahra koohestani
1
,
Mohammad-Ali Kohanpour
2
,
Craig Duncan
3
,
sara naeimi
4
1 - Physical Education Teacher of Khorasan Razavi Province, Iran
2 - Department of Physical Education and Sports Science, Zand University, Shiraz, Iran
3 - Australian Catholic University, Strathfield, Australia; Performance Intelligence Agency, Sydney, Australia
4 - Postgraduate Student of Plant Pathology, Faculty of Agriculture, Ferdowsi university, Mashhad, Iran
Keywords: Aerobic training, BDNF, cognitive status, Cognitive impairment, Olibanum,
Abstract :
Introduction: The aim of this study was to investigation of the effect of 12 weeks aerobic training and consumption of olibanum extract on cognitive status and BDNF levels in the elderly with mild cognitive impairment (MCI).Materials and Methods: 32 elderly people who scored between 21 and 25 in the MMSE questionnaire were purposefully selected and randomly divided into 4 groups: aerobic training, olibanum, aerobic training + olibanum, and placebo (N=8 in each group). Interventions were performed for 12 weeks. Aerobic training consisted of eight minutes of running with an intensity of 75 to 85% of the maximum reserve heart rate in the first session. Both sessions increased running time by one minute until after 12 weeks, the running time reached 26 minutes. Olibanum extract was taken as a capsule at a dose of 100 mg/kg body weight per day.Findings: BDNF levels in both training and training + olibanum groups increased significantly compared to the other two groups (P <0.05). Cognitive status also increased significantly in the three groups of intervention compared with the placebo group (P <0.05).Conclusion: It is possible that 12 weeks of aerobic training and olibanum can slow and possibly stop the progression of MCI by improving the cognitive status in the elderly with MCI.
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