A new phenylpropanoid glucoside from Psorospermum tenuifolium Kotschy (Hypericaceae)

Subject Areas : Natural Products: Isolation and Characterization

Gervais Mouthe Happi ¹ , Alexis Sylvain W. Mbobda ² , Marcel Frese ³ , Simeon Fogue Kouam ⁴ , Jean Claude Tchouankeu ⁵ , Bruno Ndjakou Lenta ⁶ , Norbert Sewald ⁷

1 - Department of Chemistry, Higher Teacher Training College, University of Bamenda, P.O Box 39, Bambili, Cameroon|Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany
2 - Department of Chemistry, Higher Teacher Training College, University of Yaounde I, P. O. Box 47, Yaounde, Cameroon
3 - Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany
4 - Department of Chemistry, Higher Teacher Training College, University of Yaounde I, P. O. Box 47, Yaounde, Cameroon
5 - Department of Organic Chemistry, Faculty of Sciences, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon
6 - Department of Chemistry, Higher Teacher Training College, University of Yaounde I, P. O. Box 47, Yaounde, Cameroon
7 - Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany

Received: 2020-10-04 Accepted : 2021-03-07 Published : 2021-03-01

Keywords: 2-Geranylemodin, Phenylpropanoid glucoside, <i>Psorospermum tenuifolium</i>, Emodin, Cytotoxicity, Psorospermoside,

Abstract :

A new phenylpropanoid glycoside named psorospermoside (1) possessing an allose unit was isolated from the Psorospermum tenuifolium Hook f. bark extract together with eleven known compounds. Their structures were elucidated using spectroscopic and spectrometric methods including 1D, 2D-NMR, and ESI-MS, as well as by comparison of their data with those reported in the literature. All the isolated compounds were assessed for their cytotoxicity effect on the human cervix carcinoma cell line KB3-1. Emodin (2) and its congener 2-geranylemodin (3) displayed significant cytotoxicity with IC50 values of 11.4 µM and 19.0µM, respectively. Furthermore, the chemotaxonomic significance of the isolated compounds was also discussed.

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