Chemical constituents from the leaves and liana of Salacia nitida (Benth.) N.E.Br. (Celastraceae) and their antimicrobial activities
Subject Areas : Phytochemistry: Isolation, Purification, Characterization
Brice
Mba’ning
1
(Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1, Po. Box 812, Yaoundé, Cameroon)
Joël E. T.
Ateba
2
(Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1, Po. Box 812, Yaoundé, Cameroon)
Angelbert F.
Awantu
3
(Department of Chemistry, Faculty of Science, University of Bamenda, Po. Box 39, Bambili, Cameroon)
Luciana S.
Amaral
4
(Departamento de Química, Universidade Federal de São Carlos, CP 676, 13.565-905 SP, Brazil)
Gervais M.
Happi
5
(Department of Chemistry, Higher Teacher Training College, University of Yaoundé 1, Po. Box 47, Yaoundé, Cameroon)
Beate
Neumann
6
(Inorganic Chemistry, Department of Chemistry, Faculty of Chemistry, Bielefeld University, University str. 25, Bielefeld, Germany)
Georg
Stammler
7
(Inorganic Chemistry, Department of Chemistry, Faculty of Chemistry, Bielefeld University, University str. 25, Bielefeld, Germany)
Bruno
Lenta
8
(Department of Chemistry, Higher Teacher Training College, University of Yaoundé 1, Po. Box 47, Yaoundé, Cameroon)
Silvère A.
Ngouela
9
(Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1, Po. Box 812, Yaoundé, Cameroon)
Iran
Malavazi
10
(Departamento de Genética e Evolução, Universidade Federal de São Carlos, CP 676, 13.565-905 SP, Brazil)
Etienne
Tsamo
11
(Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1, Po. Box 812, Yaoundé, Cameroon)
Norbert
Sewald
12
(Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, Po. Box 100131, D-33501 Bielefeld, Germany)
Edson
Rodrigues-Filho
13
(Departamento de Química, Universidade Federal de São Carlos, CP 676, 13.565-905 SP, Brazil)
Keywords: NMR spectroscopy, <i>Salacia nitida</i> (Benth.) N.E.Br, leaves and liana, Antimicrobial Activity, benzophenone, X-ray diffraction,
Abstract :
One benzophenone, 4′-hydroxy-2,4,6-trimethoxybenzophenone (1) was isolated from the liana and leaves of Salacia nitida (Benth.) N.E.Br., together with n-hexacosane (2), 29-hydroxyfriedelane (3), 3β-friedelinol (4), n-hexacosan-1-ol (5), n-octacosan-1-ol (6), mangiferin (7), β-sitosterol-3-O-β-D-glucopyranoside (8), friedelin (9), 30-hydroxyfriedelin (10), salaspermic acid (11), 22β-epi-maytenfolic acid (12), orthosphenic acid (13), maltose (14), D-mannitol (15), cangoronine (16), 7-hydroxyfriedelane-1,3-dione (17), tingenone (18), pristimerin (19), α-amyrin acetate (20), β-sitosterol (21) and stigmasterol (22), 21-hydroxyfriedelan-3-one (23), abruslactone A (24), and 2α-hydroxypopulnonic acid (25). The structures of the isolated compounds were established by means of spectroscopic analysis. In addition, the structure of (1) was confirmed by its X-ray diffraction. Compounds (1), (7), (10)-(11), (13), (16)-(19) and (25) were evaluated for their antimicrobial activities. Compound (18) showed a significant activity against Staphylococcus aureus (MIC = 23.8 µM) while compounds (11) and (19) exhibited moderate inhibiting effect against Staphylococcus aureus (MIC = 53.8 µM) and Candida glabrata (MIC = 105.9 µM), respectively.
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