Background & Aims: CuO is one of the most important transition metal oxides due to its interesting properties. It is used in various technological applications such as high critical temperature superconductors, gas sensors, photocatalyst, and so on. Staphylococcus a
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Background & Aims: CuO is one of the most important transition metal oxides due to its interesting properties. It is used in various technological applications such as high critical temperature superconductors, gas sensors, photocatalyst, and so on. Staphylococcus aureus bacteria causes a wide range of infectious diseases. In this study, the antimicrobial activity of the synthesized copper oxide nanoparticles in the presence of Berberis integerrima aqueous extract on the infected surgical wound caused by this bacterium was investigated in mice.
Materials and methods: First, copper oxide nanoparticles were synthesized in the presence of Berberis integerrima aqueous extract and confirmed by XRD, FT-IR, FE-SEM analyses, and the MIC and MBC levels of the nanostructures used were determined by the dilution method in Mueller Hinton Broth culture medium. Also, after creating a skin wound and inoculating the solution of Staphylococcus aureus bacteria with a concentration of (5 × 105 CFU/ml), the concentration of MBC along with Eucerin ointment was checked on the infected wounds.
Results: In general, copper oxide nanoparticles synthesized in the presence of Berberis integerrima aqueous extract has a significant antimicrobial activity to control the growth of Staphylococcus aureus bacteria. Also, the synthesized copper oxide has a favorable antimicrobial and reparative effect on the infected surgical wound caused by this bacterium.
Conclusion: According to the findings, copper oxide nanoparticles can be effectively and efficiently synthesized by Berberis integerrima aqueous extract in simple and environmentally friendly conditions. It also has a significant antibacterial effect on Staphylococcus aureus bacteria and has a favorable reparative effect compared to Eucerin ointment. Copper oxide nanoparticles can be expected to play an effective role in the treatment of microbial infections.
Key words: Berberis integerrima, copper nanoparticles, Eucerin, mice, Staphylococcus aureus.
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