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1 - Study Effects Of Hydroalcoholic Extract Of Medicago sativa in the Treatment Of Acetic Acid Induced Gastric Ulcer in Rats
Mahdi Margani Hamed Alizadeh Sina Aghshahi

Inroduction and Objective:Peptic ulcer, from histologicalpointisknownasmucosalnecrosisfactor. The purpose of this study was to investigate the effect of Alfalfa hydroalcoholicvegetivearial organs extract on gastric ulcer induced by acetic acid in Rat.Material and Method More

Inroduction and Objective:Peptic ulcer, from histologicalpointisknownasmucosalnecrosisfactor. The purpose of this study was to investigate the effect of Alfalfa hydroalcoholicvegetivearial organs extract on gastric ulcer induced by acetic acid in Rat.Material and Methods: In this experimental study, 60 wistar rats weighting approximately (200-250g) were randomly divided into 4 groups; control, sham(normal salin), experiment 1 (extract of dose 250 mg/kg body weight) and experiment 2 (extract of dose 500 mg/kg body weight). Rats were deprived of food and then underwent surgeryand gastric wasby injecting60% acetic acid after 4,7,10,14 days gavage, the rats' stomach out and then measuring the wound and fixed with 10% formalin, the passage of the tissue section was stained And the number of neutrophils, macrophages and fibroblasts were counted.Results:Results showed that the hydroalcoholic extract of Alfalfacaused a significant increase in gastric ulcer healing in experimental groups 1 and 2 (PConclusion:Alfalfahydroalcoholic vegetive arial organs extract is effective in the treatment of peptic ulcer induced by acetic acid Manuscript profile
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2 - The Study Of the effect Of ovine bladder scaffold Of sheep, ِDomesticated breed, on blastema cells in vitro
نگار صغیری هاشم راستی جواد بهارآرا ناصر مهدوی شهری مهدی مرجانی سید حسن علوی فاطمه علوی

Introduction and ObjectiveBiological scaffolds, composed of Extra Cellular Matrix (ECM), are capable of facilitating the restructuring of a large number of tissues. The objective of this study was to investigate the effect of ovine bladder scaffold of sheep, domesticate More

Introduction and ObjectiveBiological scaffolds, composed of Extra Cellular Matrix (ECM), are capable of facilitating the restructuring of a large number of tissues. The objective of this study was to investigate the effect of ovine bladder scaffold of sheep, domesticated breedon blastema cells in vitroMaterials and Methods: At first, ovine bladder o the sheep was decellularized by putting in 1% wt/vol solution of sodium dodecyl sulfate (SDS) for 24 hours. Then to prepare the blastema tissue, the pinna of New Zealand rabbit was manually punched-hole with a special puncher and a circular blastema was separated. There after, the decellularized samples were put in the middle of blastema ring and were transfered to the culture medium. To continue the study, microscope with lights of hematoxylin and eosin and pick indigo and Toluidine blue staining was used. Some samples on the day 15 and 20 of culture were studied by transitional electron microscope.Results: Collagen fibers were preserved after decellularized in matrix of bladder. Most migration of blastema cells occurred on days 15 and 20 of culture. On the day 10 and 15, some immature cells were differentiation in the pathway of adipocyte and fibroblast. On the day 15th and 20th, more blastema cells were migrated to the ovine scaffold. On the 10th and 15 day immature cell culture was seen to be differentiated from fibroblast and adipocyte cells. On the 15 th day blastema cell culture differentiated from covering cells and on the 20th day from fibroblast and adipocyte cells were seen.Conclusion: Bladder scaffold has ability to induce blastema cells and causes not only blastoma cells’ migration but also to be changed to different cells. This phenomenon is very important because of no growth factor and inducer was used in culture medium. Manuscript profile
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3 - Effect Of Anesthesia with PropOfol Following Premedication Vitamin C in Dogs
Mehdi Marjani Hamed Alizadeh Seyyed Emade Mirza Ghafour

Inroduction and Objective:Propofol is an intravenous anesthetic agent that is very useful today and is administered intravenously. Effect of Vitamin C on the central nervous system are similar to amphetamines is the moderation of central nervous system. The purpose of t More

Inroduction and Objective:Propofol is an intravenous anesthetic agent that is very useful today and is administered intravenously. Effect of Vitamin C on the central nervous system are similar to amphetamines is the moderation of central nervous system. The purpose of this study was to investigate the effect of propofol anesthesia following treatment with vitamin C in male dogs.Materials andMethods:In this experimental study, 25 dogs were divided into 5 groups. Group 1 as control (no treatment), and group 2 and anesthetic with propofol group 3 to 5, respectively treated with 100 ,250, 500µg/kg of body weight dose of vitamin C and then anesthetized with propofol. Pre and postoperative vital signs including heart rate, respiratory rate, and rectal temperature were recorded during anesthesia. Before and after anesthesia vital signs including heart rate, respiratory rate, rectal temperature and anesthesia time were recorded.Results:The comparison of parameters before and after of anesthesia induction don’t show significant differences between the experimental and control group. Moderate doses of vitamin C leads to a decrease in body temperature after the anesthesia induction. On the other hand, high doses of vitamin C leads to a reduction in the duration of anesthesia compared with control group.Conclusion:High-dose of vitamin C can be used as pre-anesthetic in dogs which there are long-term risks of anesthesia Manuscript profile

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