Effects of Hydro alcoholic Extract of Ferulago angulataon Glucose, Lipid Profile and Liver enzymes in Male Rats on High-fat Diet
Subject Areas :
Maryamsadaat moshashaei
1
,
somayeh bohlouli
2
*
1 - Department of Biology, College of Basic Science, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran.
2 - Department of Veterinary Medicine ,College of Agriculture, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran.
Keywords: High-fat diet, Lipid profile, Rat, Hydro Alcoholic Extract, Ferulago angulata,
Abstract :
Inroduction & Objective: The use of herbal supplements to prevent and stop obesity is cheaper than chemical and synthetic drugs and has fewer side effects. in this study, the effect of Ferulago angulatahydro alcoholic extract on the biochemical parameters of male rats on a high-fat diet was surveyed. Material and Method: Thirty-two male Wistar rats,which were randomly tested,were experimentally studiedin four groups: One control groupreceiving a fatty diet without extract;threeexperimental groups receiving Ferulago angulata extract of with doses of 50, 100 and 200 mg/kg. Nursing was performed for 20 weeks. At the end of the experiment, biochemical factors were tested on serum levels, including: glucose, triglycerides, cholesterol (HDL and LDL), leptin, and liver enzymes (ALT, AST, and ALP). Results: Doses of 50, 100 and 200 mg/kg of the extract reduced some biochemical and liver factors in rats compared to the control group under high-fat diet and the extract reduced cholesterol and leptin significantly. Different doses of choy extract significantly reduced the levels of leptin, glucose, triglycerides and liver enzymes (ALP / AST / ALT). LDL levels decreased. HDL levels also increased and cholesterol levels did not change Conclusion: In this study, the reducing effects of biochemical factors were observed at doses of 50, 100 and 200 mg/kg of extract, which may be evidenced by the positive effects of the extract of this plant on reducing harmful fats in the biochemical factors of the blood and the weight of the rats. Daily consumption of low dose of theextract of this plant can lead to fat metabolism and weight loss.
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