Central synergistic effects of histamine and adrenaline on food intake and plasma cortisol in broilers

Subject Areas : Experimental physiology and pathology

Mostafa   Daneshvar ¹ (Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran.)
Morteza  Zendehdel ² (Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran)
Bita   Vazir ³ (Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran)
Ahmad   Asghari ⁴ (Department of Clinical Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran)

Received: 2024-03-06 Accepted : 2024-05-16 Published : 2024-05-22

Keywords: Food intake, Adrenaline, Histamine, Cortisol, Broilers,

Abstract :

Background & Aim: Years of research on the physiological pathways that regulate appetite have led to the identification of dozens of neural mediators involved in this process. Based on these studies, the role of histaminergic and adrenergic systems in regulating food intake has been proven. The aim of the current study is to investigate the central synergistic effects of histamine and adrenaline on food intake and plasma cortisol in broiler chickens. Materials and Methods: In order to achieve this goal, three experiments were designed, each including one control group and three treatment groups. In the first test, control solution and histamine were prescribed with doses of 75, 150, and 300. In the second test, the control solution and adrenaline were injected with doses of 75, 150, and 300 nmol, and in the third test, in addition to the control solution, histamine (75 nmol), adrenaline (75 nmol) and histamine + adrenaline were injected. Then, chickens were returned to their cages and their food intake was recorded as a percentage of body weight. After the end of the experiments, by cutting the head, blood was taken and the plasma cortisol level was evaluated in all groups. Results: Based on the findings, simultaneous administration of sub effective doses of histamine and adrenaline caused a significant decrease in food intake (P≤0.05) and a significant increase in plasma cortisol levels (P≤0.01). Conclusion: According to the results, it seems that there is a synergistic effect between histamine and adrenaline in controlling food intake and plasma cortisol levels

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