Mathematical Modeling for Sustained and Controlled Release of Tacrolimus Ophthalmic Drug Loaded on Chitosan and Nanoliposome

Subject Areas :

Parisa Hasansheikhi ¹ , Elham Ameri ^{2 *} , Zahra Alimohamadi ³

1 - Ph.D. Candidate, Department Of Chemical Engineering Shahreza Branch, Islamic Azad University, Shahreza, Iran.
2 - Associate Professor, Department Of Chemical Engineering, NT.C., Islamic Azad University, Najafabad, Iran
3 - Assistant Professor, Department Of Chemical Engineering, Najafabad Branch Islamic Azad University, Shahreza, Iran

Received: 2024-07-26 Accepted : 2024-09-19 Published : 2025-07-08

Keywords: composite, nanoliposome, morphology, tacrolimus, chitosan,

Abstract :

In the present study, active loading of tacrolimus drug on liposome-chitosan composite was investigated. The construction and improvement of the carriers are investigated and characterized by various tests and the medicine was loaded on the carriers. Transport mechanisms in the delivery and controlled release of various drugs to the eye are very complex. In this study, it is placed inside a lipid matrix and used for drug administration. Release modeling is a bit complicated due to the moving and initial boundary conditions. Therefore, in this article, mathematical methods were used to solve the equation in initial and boundary conditions. These equations are simplified to be solved analytically. According to all the solutions of the models, the method of separation of variables is used and this study suggests that diffusion kinetics will be an implicit achievement by examining and identifying the most appropriate mathematical conditions and still experimental models for the first solution remain to be investigated. As a perspective of the future, it can be said that mathematical theories have potential advantages and limitations, but they are discussed with the aim of facilitating the design of drug delivery systems and improving drug efficiency. In this study, the results showed that the highest amount of permeability factor is related to the liposome made of EPC lipid and the lowest permeability factor values are related to the liposome made of DPPC60 lipid.

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