This research was applied in terms of purpose and in terms of method it was a semi-experimental cross-sectional study with a pre-test-post-test-follow-up design. The statistical population included all cancer patients in Bushehr city from November 2019 to April 2014. From this population, 40 people were selected by available sampling method and randomly assigned to four groups of 10 people (three experimental groups and one control group). World Health Organization quality of life questionnaires (1996) and Beck depression questionnaires (1998) were administered to all participants as a pre-test. Then the people of the first experimental group received behavioral activation group therapy, the second experimental group received therapy based on acceptance and commitment, and the third experimental group also received cognitive therapy based on mindfulness in ten 90-minute sessions. But people in the control group did not receive intervention. Due to the corona situation, therapeutic interventions were held in the form of video calls. Finally, the aforementioned questionnaires were administered to all participants as a post-test. In order to follow up the effectiveness, after one month, all the participants answered the questionnaires again. The findings were analyzed using analysis of variance with repeated measurements and Tukey and Bonferroni post hoc tests. Based on the results, the mean post-test scores of the patients of all three test groups in the variables of depression and quality of life had a significant decrease and increase, respectively, compared to the control group (P<0.05). These differences were also significant in the follow-up phase (P<0.05). However, the difference in the effectiveness of the three mentioned treatments on reducing depression and increasing quality of life was not significant (P>0.05).
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