Comparison of the effects of Omperazole and Rabeprazole in prevention of Indomethacin induced gastric ulcers in rats

Subject Areas : clinical veterinary science

بابک Rezvanjoo ¹ , ابوالفضل Baghaikia ² , فریبرز Moayer ³ , M. Ghafari ⁴ , S.H Shirazi-beheshtiha ⁵

1 - Department of Basic Sciences, Faculty of Veterinary Medicine, Karaj Branch, Islamic Azad University, Karaj, Iran
2 - Faculty of Veterinary Medicine, Karaj Branch, Islamic Azad University, Karaj, Iran
3 - epartment of Pathobiology, Faculty of Veterinary Medicine, Karaj Branch, Islamic Azad University, Karaj, Iran
4 - Department of Clinical Sciences, Faculty of Veterinary Medicine, Karaj Branch, Islamic Azad University, Karaj, Iran
5 - Department of Clinical Sciences, Faculty of Veterinary Medicine, Karaj Branch, Islamic Azad University, Karaj, Iran

Received: 2016-11-03 Accepted : 2016-11-03 Published : 2013-03-21

Keywords: Rat, Rabeperazole, Omeprazole, Peptic ulcers,

Abstract :

Peptic ulcer is a common disease in veterinary and human medicine.Protective factors in gastrointestinal tractcontain: mucosal defense, prostaglandin G, local circulation, mucous, Antioxidants (vitamin E, vitamin C,melatonin, Superoxide dismutase). Ulcerogenic factors in gastrointestinal tract contain: HP, acid, pepcin, stress,Genetic, free radicals, NSAIDs, duodenogastric reflux, virus, zollinger- ellison syndrom.Indomethacin is a NSAID drug. Omeprazole, rabeprazole and pantoprazole are Proton Pump Inhibitor (PIP) drugs.This study have performed on 6 groups of rats: saline, indomethacin, omeprazole (10mg/kg) + indomethacin,omprazole (1mg/kg) + indomethacin, rabeprazole (10mg/kg) + indomethacin, rabeprazole (1mg/kg) +indomethacin. All rats were killed 4 hours after the last injection of indomethacin and stomachs were prepared forcalculation of j.score and histopathological study.In indomethacin group, injection of indomethacin was associated with signifcant increased in j.score comparedwith saline group. Injection of omeprazole and rabeprazole, was associated with signifcant decrease in j.scorecompared with indomethacin group.Injection of rabeprazole, was associated with signifcant decrease in j.scorecompared with omeprazole group. Histopathological results confrmed j.score results.