The effect of phenylbutazone injection on serumic levels of thyroid hormones in the horse
Subject Areas : Veterinary Clinical PathologyAli Hassanpour 1 , Vahid Farshchi Andisi 2 , مجید Ebrahimi Hamed 3 , فرهاد Farhangpajoh 4
1 - گروه علوم درمانگاهی، دانشکده دامپزشکی، دانشگاه آزاد اسلامی تبریز، تبریز، ایران
2 - Graduated of Veterinary Medicine, Islamic Azad University of Tabriz, Tabriz, Iran
3 - Department of Clinical Sciences, Faculty of Veterinary Medicine, Islamic Azad University of Urmia, Urmia, Iran
4 - Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Urmia, Urmia, Iran
Keywords: thyroid hormones, horse, Phenylbutazone,
Abstract :
This study was conducted to evaluate the effect of phenylbutazone injection on serumic levels of thyroid hormones in the Arabian horse. Twelve Arabian horses were allocated to two groups of control and treatment each consisting of six animals. In the treatment group, 3 mg/kg phenylbutazone was injected intravenously for 6 days while in the control group equal values of 0.9% NaCl solution was used for the injection. Blood samples of all animals were collected from the jugular vein at days 0(before injection), 1, 2, 3, 4, 5 and 6, their sera separated by centrifuging and the levels of T3 and T4 were measured using the ELISA technique. There was a significant difference (P
1. Alberts, M.K., McCann, J.P. and Woods, P.R (2000): Hemithyroidectomy in a horse with confirmed hyperthyroidism, J. Am. Vet. Med. Assoc. 217: 1051-1054.
2. Bayly, W., Andrea, R., Smith, B. and Tiged, P. (1996): Thyroid hormone concentrations in racing thoroughbreds, Pferdeheilkunde 4: 534-538.
3. Breuhaus, B.A (2002): Thyroid stimulating hormone in adult euthyroid and hypothyroid horses, J. Vet. Int. Med. 16: 109-115.
4. Flier, J.S., Harris, M. and Hollenberg, A.N. (2000): Leptin, nutrition and the thyroid: the why, the wherefore, and the wiring, J. Clin. Invest. 105: 859-961.
5. Forhead, A.J., Li, J. and Gillmour, R. (2002): Thyroid hormones and the mRNA of the GH receptor and IGFs in skeletal muscle of fetal sheep, Am. J. Physiol. Endocrinol. Metab. 282: E80-E86.
6. Gentry, L.R., Thompson, D.L. and strelzer, A.M., (2002): Responses of seasonally unovulatory mares to daily administration of thyrotropin releasing hormone and (or) gonadotropin – releasing hormone analog, J. Anim. Sci. 80: 208-213.
7. Johnson, P.J.Y., (2002): The equine metabolic syndrome: peripheral Cushing's Syndrome, Vet. Clin. North. Am. 18: 271-294.
8. Kantrowitz, L.B., Peterson, M.E. and Melian, C. (2001): Serum total thyroxine, total triiodothronine, free thyroxine, and thyrotropin concentrations in dogs with nonthyroidal disease, J. Am. Vet. Med. Assoc. 219: 765-769.
9. McManus, C.J. and Fitzerald, B.P., (2000): Effects of a single day of feed restriction on changes in serum leptin, gonadotropins, prolactin, and metabolites in aged and young mares, Domest. Anim. Endocrinol. 19: 1-13.
10. Messer, N.T., Ganjam, V.K., Nachreiner, R.F. and Krause, G.F. (1995): Effect of dexamethasone administration on serum thyroid hormone concentrations in clinically normal horses, J. Am. Vet. Med. Assoc. 206(1):63-6.
11. Morris, D.D. and Garcia, M.C., (1985): Effects of phenylbutazone and anabolic steroids on adrenal and thyroid gland function tests in healthy horses, Am. J. Vet. Res. 46(2):359-64.
12. Patel, Y.C (2001): Neurotransmitters and hypothalamic control of anterior pituitary function. 1st ed. Saunders, Philadelphia, pp: 136-147.
13. Pezzi, C., Accorsi, P.A., Vigo, D., Govoni, N, and Gaiani. R (2003): -deiodinase activity and circulating thyronines in lactating cows, J. Dairy Sci. 86: 152-158.
14. Ramirez, S., Wolfsheimer, K.J. and Moore, R.M. (1997): Duration of effects of phenylbutazone on serum total thyroxine and free thyroxine concentrations in horses. J. Vet. Int. Med. 11: 371-374.
15. Reichln, S. Neuroendocrinology. In: Wilson, J.D., Foster, D.W. and Kronenberg, H.M. (1998): William's textbook of endocrinology. 2nd ed. Saunders, Philadelphia, pp: 241-263.
16. Suwannachot, P., Verkleij, C.B. and Kocsis, S. (2000): Prolonged food restriction and mild exercise in Shetland ponies: effects on weight gain, thyroid hormone concentrations and muscle Na (+), K(+)- ATPase, J. Endocrinol. 167: 321-329.
17. Wehr, U., Englschalk, B. and Kienzle, E. (2002) Iodine balance in relation to iodine intake in ponies, J.Nutr. 132: 1767S-1768S.