Investigation of clinical and histopathological effects of Rofecoxib after surgical trauma of the gum in rabbit

Subject Areas : Veterinary Clinical Pathology

Ali Rezaie ¹ , داریوش Mohajeri ² , آرش Khaki ³ , افشین Akbari ⁴

1 - Department of Clinical Science, Veterinary Faculty, Islamic Azad University of Tabriz, Tabriz, Iran.
2 - Department of Pathobiology, Veterinary Faculty, Islamic Azad University of Tabriz, Tabriz, Iran.
3 - Graduated from Veterinary Medicine, Islamic Azad University of Tabriz, Tabriz, Iran.
4 - Graduated from Veterinary Medicine, Islamic Azad University of Tabriz, Tabriz, Iran

Received: 2008-01-04 Accepted : 2008-01-04 Published : 2007-05-22

Keywords: Rabbit, Healing, Rofecoxib, surgical trauma, Gum,

Abstract :

  In this study, clinical and histopathological effects of Rofecoxib, which is usually used in surgery as an analgesic and anti inflammatory drug is evaluated on the process of healing following surgical trauma. 15 New Zealand white rabbits with the same condition were selected and after numbering, divided to three different groups so that there were 5 rabbits per group. Then in each group after anesthesia  with Xylazine and Ketamine a circular surgical trauma was created in the right lateral region of mandible using punch biopsy and after 12 days, clinical and histopathological effects of treatment with low dose (6 mg/kg/day) and high dose (12 mg/kg/day) Rofecoxib was compared with control group that received placebo. It was evident that use of this drug had positive effects on healing which was obvious from clinical findings and comparison of photomicrographs of the healing site in both low dose and high dose treatment groups compared with control group. Also it was determined that use of high dose of Rofecoxib had better effects on healing process compared to low dose of this drug.

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