The Effect of Selenium Supplementation on Serum Levels of Creatine Kinase, Lactate Dehydrogenase and Muscle Strength at Resting and after a Soccer Match in Young Soccer Players
Subject Areas : Microbiology
1 - MSc of the Department of Physical Education and Sport Sciences, Saghez Branch, Islamic Azad University, Saghez, Iran.
2 - Assistant Professor of the Department of Physical Education and Sport Sciences, Saghez Branch, Islamic Azad University, Saghez, Iran.
Keywords: Creatine Kinase, Lactate Dehydrogenase, Muscle Strength, Selenium, Soccer Players,
Abstract :
Introduction: Few researches have been carried out on the effect of selenium supplementation on muscle damage in athletes. The aim of this study is to investigate the effect of selenium supplementation on serum levels of creatine kinase (CK), lactate dehydrogenase (LDH) and muscle strength at resting and after a soccer match in young soccer players. Materials and Methods: The research method was quasi-experimental and 19 young soccer players were selected among soccer players in Saghez city and were randomly divided into two experimental (supplementation, n=10) and control (placebo, n=9) groups. The assessments were carried out in three stages (pre-supplementation, post-supplementation, and immediately after the match). General characteristics of subjects, muscle strength, and circulating levels of LDH and CK were measured. The supplementation period was one month (one 200 µg/ml selenium capsule daily). The placebo group also consumed a starch capsule each day. In order to analyze the data, two factor analysis of variance with repeated measures were used at the significant level of P<0.05. Results: Selenium supplementation has no effect on muscle strength (bench-press p=0.790, leg-press p=0.912) and levels of CK (p=0.051) and LDH (p=0.244) at rest and after the soccer match. Conclusion: Selenium supplementation for one month and a daily intake of 200 μg does not appear to have a beneficial or harmful effect on muscle strength and circulating levels of enzymes indicating muscle damage at rest and following a soccer match in young soccer players. More research is needed to reveal various aspects of the issue.
Akil, M., Gurbuz, U., Bicer, M., Sivrikaya, A., Mogulkoc, R. & Baltaci, A. K. (2011).
Effect of selenium supplementation on lipid peroxidation, antioxidant enzymes, and lactate levels in rats immediately after acute swimming exercise. Biological Trace Element Research, 142(3), 651-9.
Amirdizaj, V. D. & Mocheshi, S. S. (2016). Muscle injury and oxidative stress following the use of selenium supplements and exhaustive aerobic exercise in young physically-active females. Journal of Kermanshah University of Medical Sciences, 20(1), 1-5
Baird, M. F., Graham, S. M., Baker, J. S. & Bickerstaff, G. F. (2012). Creatine kinase- and exercise-related muscle damage implications for muscle performance and recovery. Journal of Nutrition and Metabolism, 2012, 960363.
Baltaci, A. K., Mogulkoc, R., Akil, M. & Bicer, M. (2016). Review - Selenium - Its metabolism and relation to exercise. Pakistan Journal of Pharmaceutical Sciences, 29(5), 1719-1725.
Callegari, G. A., Novaes, J. S., Neto, G. R., Dias, I., Garrido, N. D. & Dani, C. (2017). Creatine kinase and lactate dehydrogenase responses after different resistance and aerobic exercise protocols. Journal of Human Kinetics, 58, 65-72.
Chariot, P. & Bignani, O. (2003). Skeletal muscle disorders associated with selenium deficiency in humans. Muscle Nerve, 27(6), 662-8.
Dallak, M. (2017). A synergistic protective effect of selenium and taurine against experimentally induced myocardial infarction in rats. Archives of Physiology and Biochemistry, 123(5), 344-355.
Fischer, J., Bosse, A. & Pallauf, J. (2008). Effect of selenium deficiency on the antioxidative status and muscle damage in growing turkeys. Archives of Animal Nutrition, 62(6), 485-97.
Jablonska, E., Reszka, E., Gromadzinska, J., Wieczorek, E., Krol, M. B., Raimondi, S. (2016). The Effect of selenium supplementation on glucose homeostasis and the expression of genes related to glucose metabolism. Nutrients, 8(12), pii:E772.
Karunasinghe, N., Zhu, S. & Ferguson, L. R. (2016). Benefits of selenium supplementation on leukocyte DNA integrity interact with dietary micronutrients: a short communication. Nutrients, 8(5), 249.
Kim, S. S., Koo, J. H., Kwon, I. S., Oh, Y. S., Lee, S. J., Kim, E. J. (2011). Exercise training and selenium or a combined treatment ameliorates aberrant expression of glucose and lactate metabolic proteins in skeletal muscle in a rodent model of diabetes. Nutrition Research and Practice, 5(3), 205-13.
Lauretani, F., Semba, R. D., Bandinelli, S., Ray, A.L., Guralnik, J. M. & Ferrucci, L. (2007). Association of low plasma selenium concentrations with poor muscle strength in older community-dwelling adults: the InCHIANTI Study. American Journal of Clinical Nutrition, 86(2), 347–352.
Logemann, E., Krützfeldt, B. & Rokitzki, L. (1989). Selenium determination in blood plasma samples of high performance athletes. Beiträge zur Gerichtlichen Medizin, 47, 97-102.
Margaritis, I., Rousseau, A. S., Hininger, I., Palazzetti, S., Arnaud, J. & Roussel, A. M. (2005). Increase in selenium requirements with physical activity loads in well-trained athletes is not linear. Biofactors, 23(1), 45-55.
Margaritis, I., Tessier, F., Prou, E., Marconnet, P. & Marini, J. F. (1997). Effects of endurance training on skeletal muscle oxidative capacities with and without selenium supplementation. Journal of Trace Elements in Medicine and Biology, 11(1), 37-43.
Maud, P. J. & Foster, C. (2006). Physiological assessment of human fitness. 2nd ed, Human Kinetics, 185-190.
Omrani, H., Golmohamadi, S., Pasdar, Y., Jasemi, K. & Almasi, A. (2016). Effect of selenium supplementation on lipid profile in hemodialysis patients. Journal of Renal Injury Prevention, 5(4), 179–182.
Rossi, B., Siciliano, G., Risaliti, R. & Muratorio, A. (1990). Effects of selenium and vitamin E on muscular strength and blood parameters in Steinert disease. Italian Journal of Neurological Sciences, 11(1), 37-42.
Şlencu, B. G., Ciobanu, C., Solcan, C., Anton, A., Ciobanu, S., Solcan, G. (2015). Effect of selenium supplementation on serum amylase, lactate dehydrogenase and alkaline phosphatase activities in rats exposed to cadmium or lead. Cercetari Agronomice in Moldova, 47(4), 113–121.
Soares, J.C., Folmer, V. & Rocha, J. B. (2003). Influence of dietary selenium supplementation and exercise on thiol-containing enzymes in mice. Nutrition, 19(7-8), 627-32.
Ueda, Y., Whanger, P. D. & Forsberg, N. E. (1999). The effects of selenium deficiency on differentiation, degradation, and cell lysis of L8 rat skeletal muscle cells. Biological Trace Element Research, 69(1), 1-13.
White, S. H., Johnson, S. E., Bobel, J. M. & Warren, L. K. (2016). Dietary selenium and prolonged exercise alter gene expression and activity of antioxidant enzymes in equine skeletal muscle. Journal of Animal Science, 94(7), 2867-2878.
White, S. H., Wohlgemuth, S., Li, C. & Warren, L. K. (2017). Rapid Communication: Dietary selenium improves skeletal muscle mitochondrial biogenesis in young equine athletes. Journal of Animal Science, 95(9), 4078-4084.
Akil, M., Gurbuz, U., Bicer, M., Sivrikaya, A., Mogulkoc, R. & Baltaci, A. K. (2011).
Effect of selenium supplementation on lipid peroxidation, antioxidant enzymes, and lactate levels in rats immediately after acute swimming exercise. Biological Trace Element Research, 142(3), 651-9.
Amirdizaj, V. D. & Mocheshi, S. S. (2016). Muscle injury and oxidative stress following the use of selenium supplements and exhaustive aerobic exercise in young physically-active females. Journal of Kermanshah University of Medical Sciences, 20(1), 1-5
Baird, M. F., Graham, S. M., Baker, J. S. & Bickerstaff, G. F. (2012). Creatine kinase- and exercise-related muscle damage implications for muscle performance and recovery. Journal of Nutrition and Metabolism, 2012, 960363.
Baltaci, A. K., Mogulkoc, R., Akil, M. & Bicer, M. (2016). Review - Selenium - Its metabolism and relation to exercise. Pakistan Journal of Pharmaceutical Sciences, 29(5), 1719-1725.
Callegari, G. A., Novaes, J. S., Neto, G. R., Dias, I., Garrido, N. D. & Dani, C. (2017). Creatine kinase and lactate dehydrogenase responses after different resistance and aerobic exercise protocols. Journal of Human Kinetics, 58, 65-72.
Chariot, P. & Bignani, O. (2003). Skeletal muscle disorders associated with selenium deficiency in humans. Muscle Nerve, 27(6), 662-8.
Dallak, M. (2017). A synergistic protective effect of selenium and taurine against experimentally induced myocardial infarction in rats. Archives of Physiology and Biochemistry, 123(5), 344-355.
Fischer, J., Bosse, A. & Pallauf, J. (2008). Effect of selenium deficiency on the antioxidative status and muscle damage in growing turkeys. Archives of Animal Nutrition, 62(6), 485-97.
Jablonska, E., Reszka, E., Gromadzinska, J., Wieczorek, E., Krol, M. B., Raimondi, S. (2016). The Effect of selenium supplementation on glucose homeostasis and the expression of genes related to glucose metabolism. Nutrients, 8(12), pii:E772.
Karunasinghe, N., Zhu, S. & Ferguson, L. R. (2016). Benefits of selenium supplementation on leukocyte DNA integrity interact with dietary micronutrients: a short communication. Nutrients, 8(5), 249.
Kim, S. S., Koo, J. H., Kwon, I. S., Oh, Y. S., Lee, S. J., Kim, E. J. (2011). Exercise training and selenium or a combined treatment ameliorates aberrant expression of glucose and lactate metabolic proteins in skeletal muscle in a rodent model of diabetes. Nutrition Research and Practice, 5(3), 205-13.
Lauretani, F., Semba, R. D., Bandinelli, S., Ray, A.L., Guralnik, J. M. & Ferrucci, L. (2007). Association of low plasma selenium concentrations with poor muscle strength in older community-dwelling adults: the InCHIANTI Study. American Journal of Clinical Nutrition, 86(2), 347–352.
Logemann, E., Krützfeldt, B. & Rokitzki, L. (1989). Selenium determination in blood plasma samples of high performance athletes. Beiträge zur Gerichtlichen Medizin, 47, 97-102.
Margaritis, I., Rousseau, A. S., Hininger, I., Palazzetti, S., Arnaud, J. & Roussel, A. M. (2005). Increase in selenium requirements with physical activity loads in well-trained athletes is not linear. Biofactors, 23(1), 45-55.
Margaritis, I., Tessier, F., Prou, E., Marconnet, P. & Marini, J. F. (1997). Effects of endurance training on skeletal muscle oxidative capacities with and without selenium supplementation. Journal of Trace Elements in Medicine and Biology, 11(1), 37-43.
Maud, P. J. & Foster, C. (2006). Physiological assessment of human fitness. 2nd ed, Human Kinetics, 185-190.
Omrani, H., Golmohamadi, S., Pasdar, Y., Jasemi, K. & Almasi, A. (2016). Effect of selenium supplementation on lipid profile in hemodialysis patients. Journal of Renal Injury Prevention, 5(4), 179–182.
Rossi, B., Siciliano, G., Risaliti, R. & Muratorio, A. (1990). Effects of selenium and vitamin E on muscular strength and blood parameters in Steinert disease. Italian Journal of Neurological Sciences, 11(1), 37-42.
Şlencu, B. G., Ciobanu, C., Solcan, C., Anton, A., Ciobanu, S., Solcan, G. (2015). Effect of selenium supplementation on serum amylase, lactate dehydrogenase and alkaline phosphatase activities in rats exposed to cadmium or lead. Cercetari Agronomice in Moldova, 47(4), 113–121.
Soares, J.C., Folmer, V. & Rocha, J. B. (2003). Influence of dietary selenium supplementation and exercise on thiol-containing enzymes in mice. Nutrition, 19(7-8), 627-32.
Ueda, Y., Whanger, P. D. & Forsberg, N. E. (1999). The effects of selenium deficiency on differentiation, degradation, and cell lysis of L8 rat skeletal muscle cells. Biological Trace Element Research, 69(1), 1-13.
White, S. H., Johnson, S. E., Bobel, J. M. & Warren, L. K. (2016). Dietary selenium and prolonged exercise alter gene expression and activity of antioxidant enzymes in equine skeletal muscle. Journal of Animal Science, 94(7), 2867-2878.
White, S. H., Wohlgemuth, S., Li, C. & Warren, L. K. (2017). Rapid Communication: Dietary selenium improves skeletal muscle mitochondrial biogenesis in young equine athletes. Journal of Animal Science, 95(9), 4078-4084.