The Effect of the water nitrate on the histology and liver Enzymes in pregnant NMRI mice
Subject Areas : Developmental biology of plants and animals , development and differentiation in microorganisms
Keywords: pregnancy, water, Nitrate, liver, AST, ALT,
Abstract :
In this study the effects of excess nitrate in drinking water on liver cells of pregnancy mice were studied . For this purpose in this research the effects of the Sodium Nitrate (doses 50, 450,900 mg ∕ liter in drinking water) during pregnancy of female mice were investigated and Blood from the left ventricle and liver tissue was studied histologically. The One-Wey ANOVA and SPSS software were used to determine the statistical significance of differences between the values for the experimental and control groups and also Image J software were used to cell counter. The results obtained showed a significant decrease in Weight of pregnant mice, increase ALT and AST enzymes, and also histological changes. These observations indicate the toxicity of excess nitrates can make histological changes and tissue damages, and increased liver enzymes.
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