A review of common animal models in reproductive biology studies
Subject Areas : Developmental biology of plants and animals , development and differentiation in microorganisms
ramazan
khanbabaee
1
(Department of Biology, Faculty of Basic Sciences, Ghaemshahr Branch, Islamic Azad University, Ghaemshahr, Iran)
nahideh
nazdikbin yamchi
2
(Department of Biology, Faculty of Basic Sciences, Ghaemshahr Branch, Islamic Azad University, Ghaemshahr, Iran)
Keywords: animal model, Premature ovarian failure, Azoospermia and Polycystic ovary syndrome,
Abstract :
One of the major problems in today's world is the inability to have children. This has affected social health and led researchers to preclinical studies. Over several decades, numerous animal models in the biology of reproduction have entered the field of research. Different mechanisms and approaches induce different types of reproductive diseases. Variety in conventional methods in inducing animal models has confused researchers. Since premature ovarian failure, azoospermia and polycystic ovary syndrome are important causes of inability of couples to have children, we decided to review the studies conducted in this field, appropriate laboratory methods and processes to create an animal model for premature failure. Introduce ovarian, azoospermia and polycystic ovary syndrome. The use of chemical drugs used in adults as chemotherapy drugs, especially cyclophosphamide, is known as the most appropriate method to create an animal model in premature ovarian failure. To create an animal model of azoospermia, busulfan injection is used as the most common method to induce azoospermia. Finally, to create an animal model of polycystic ovary syndrome, the most common method is to inject androgens into dihydroepiandestrone. In the present study, common methods along with the relevant protocols, along with the advantages and disadvantages of each model are presented.
_||_