Investigating the Antimicrobial Effects of Nisome Nontaining Savory Plant (Satureja macrantha)Extract on the Pathogen Staphylococcus aureus and Escherichia coli

Subject Areas : Developmental biology of plants and animals , development and differentiation in microorganisms

Fahimeh  Najafi ¹ (Department of chemistry,Roudehen Branch, Islamic azad University, Roudehen, Iran)
Fatemehsadat  Valizadeh ² (Department of chemistry, Roudehen branch, Islamic Azad University,Roudehen,Iran)
simin  nabizadeh ³ (Department of Biology, Roudehen branch, Islamic Azad University)
Ali Asghar  Bagheri ⁴ (Department of Biology, Roudehen branch, Islamic Azad University,Roudehen,Iran)
Amir  Mirzaei ⁵ (-Department of Biology, Parand branch, Islamic Azad University)

Received: 2022-12-21 Accepted : 2023-03-14 Published : 2023-11-22

Keywords: antibiotic, savory, Niosome, Staphylococcus aureus and Escherichia coli,

Abstract :

The savory(Satureja macrantha) belongs to the mint family, it is an annual or multi-year plant, Iran has 12 annual or multi-year grass species. In many studies, antimicrobial, antiviral, antifungal, antispasmodic, stomach strengthening and digestion facilitating properties of this genus have been reported. Nisome is a important surfactant-based non-ionic vesicle. Niosomes offer several advantages for drug delivery systems, including osmotically active, chemical stability and long retention time compared to liposomes. In the present study, niosomes extracted from as a drug are dynamically evaluated by calorimetric method (Folin's method). In this study niosomes formulation containing Satureja macrantha extract, in order to achieve the optimal formulation, different formulations were prepared based on the molar ratio of Span 60/Tween 60, cholesterol and with a sonication time of 7 minutes. The niosomes extracted from the savory plant significantly inhibited the activity of the two bacteria(Staphylococcus aureus ) and (Escherichia coli) tested in the present study.

References:

• Gharbavi M, Amani J, Kheiri-Manjili H, Danafar H, Sharafi A. Niosome: A Promising Nanocarrier for Natural Drug Delivery through Blood-Brain Barrier. Advances in Pharmacological Sciences. 2018;2018:6847971.


• Singh TG, Sharma N. Chapter 7 - Nanobiomaterials in cosmetics: current status and future prospects. In: Grumezescu AM, editor. Nanobiomaterials in Galenic Formulations and Cosmetics: William Andrew Publishing; 2016. p. 149-74.


• Mukherjee B, Chakraborty S, Mondal L, Satapathy BS, Sengupta S, Dutta L, et al. Chapter 7 - Multifunctional drug nanocarriers facilitate more specific entry of therapeutic payload into tumors and control multiple drug resistance in cancer. In: Grumezescu AM, editor. Nanobiomaterials in Cancer Therapy: William Andrew Publishing; 2016. p. 203-51.


• Akbarzadeh I, Keramati M, Azadi A, Afzali E, Shahbazi R, Chiani M, et al. Optimization, physicochemical characterization, and antimicrobial activity of a novel simvastatin nano-niosomal gel against E. coli and S. aureus. Chemistry and physics of lipids. 2021;234:105019.


• Kashef MT, Saleh NM, Assar NH, Ramadan MA. The Antimicrobial Activity of Ciprofloxacin-Loaded Niosomes against Ciprofloxacin-Resistant and Biofilm-Forming Staphylococcus aureus. Infect Drug Resist. 2020;13:1619-29.


• Shirvany A, Rezayan AH, Alvandi H, Barshan Tashnizi M, Sabahi H. Preparation and Evaluation of a Niosomal Drug Delivery System Containing Cefazolin and Study of Its Antibacterial Activity. Iranian Journal of Medical Microbiology. 2021;15(6):638-5


• Moghtaderi M, Mirzaie A, Zabet N, Moammeri A, Mansoori-Kermani A, Akbarzadeh I, et al. Enhanced Antibacterial Activity of Echinacea angustifolia Extract against Multidrug-Resistant Klebsiella pneumoniae through Niosome Encapsulation. Nanomaterials. 1573:(6)11:2021..


• Hagh LG, Arefian A, Farajzade A, Dibazar S, Samiea N. The antibacterial activity of "Satureja hortensis" extract and essential oil against oral bacteria. Dental research journal. 2019;16(3):153-9.


• Yeo PL, Lim CL, Chye SM, Kiong Ling AP, Koh RY. Niosomes: a review of their structure, properties, methods of preparation, and medical applications. Asian Biomedicine. 2017;11(4):301-14.


• Barakat HS, Kassem MA, El-Khordagui LK, Khalafallah NM. Vancomycin-eluting niosomes: a new approach to the inhibition of staphylococcal biofilm on abiotic surfaces. AAPS PharmSciTech. 2014;15(5):1263-74.


• Gharbavi M, Amani J, Kheiri-Manjili H, Danafar H, Sharafi A. Niosome: A Promising Nanocarrier for Natural Drug Delivery through Blood-Brain Barrier. Adv Pharmacol Sci. 2018;2018:6847971.


• Christensen GD, Simpson WA, Younger JJ, Baddour LM, Barrett FF, Melton DM, et al. Adherence of coagulase-negative staphylococci to plastic tissue culture plates: a quantitative model for the adherence of staphylococci to medical devices. J Clin Microbiol. 1985;22(6):996-1006.


• Jamil B, Syed MA. Nano-antimicrobials: A Viable Approach to Tackle Multidrug-Resistant Pathogens. In: Rai M, Alves dos Santos C, editors. Nanotechnology Applied To Pharmaceutical Technology. Cham: Springer International Publishing; 2017. p. 31-54.


• Kumar GP, Rajeshwarrao P. Nonionic surfactant vesicular systems for effective drug delivery—an overview. Acta Pharmaceutica Sinica B. 2011;1(4):208-19.


• Ahmaditabar P, Momtazi-Borojeni AA, Rezayan AH, Mahmoodi M, Sahebkar A, Mellat M. Enhanced Entrapment and Improved in Vitro Controlled Release of N-Acetyl Cysteine in Hybrid PLGA/Lecithin Nanoparticles Prepared Using a Nanoprecipitation/Self-Assembly Method. Journal of cellular biochemistry. 2017;118(12):4203-9.

Wu ZL, Zhao J, Xu R. Recent Advances in Oral Nano-Antibiotics for Bacterial Infection Therapy. Int J Nanomedicine. 2020;15:9587-610