Modeling the androgen deprivation therapy in metastatic castration-resistant prostate cancer and identifying the responder and non-responder patients before starting the treatment

Subject Areas : Developmental biology of plants and animals , development and differentiation in microorganisms

Mahdi Sohrabi-Haghighat ¹ (Faculty of Sciences,, Arak University, Arak, Iran)
Atefeh Deris ² (Graduated from Arak University)

Received: 2021-01-27 Accepted : 2021-03-05 Published : 2021-02-19

Keywords: Metastatic Castrate-Resistant, Evolutionary Dynamic, Androgen Deprivation Therapy, Evolutionarily Stable Strategy,

Abstract :

Androgen deprivation therapy is a common treatment method of metastatic castration resistant prostate cancer disease aimed at slowing down the cancer cells growth by reducing the concentration of androgen in the blood. However, only some patients respond to the androgen deprivation therapy effectively. In the other patients, the population of cancer cells reduce temporarily, and the cancer recurrence will be observed shortly after the treatment. In this paper, the response mechanism of cancer cells to the androgen deprivation therapy is analyzed by modeling the treatment based on the evolutionary dynamic which is fully supported by clinical observations. The study determines the group of patients on whom the androgen deprivation therapy is effective and the group on whom it is ineffective or even harmful. In the following, by simulating the treatment process under different schedules of abiraterone administration, the results of different treatment methods will be determined and appropriate schedules are discussed.