Abstract: This research introduces a simple, sensitive, and rapid ultraviolet- visible
spectrophotometry method for determination of ultra-trace amount of Ranitidine (RAN)
in several sample such as drinking water, tablet, serum (blood), and human urine using
gold nan
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Abstract: This research introduces a simple, sensitive, and rapid ultraviolet- visible
spectrophotometry method for determination of ultra-trace amount of Ranitidine (RAN)
in several sample such as drinking water, tablet, serum (blood), and human urine using
gold nanoparticles (AuNPs). The surface plasmon resonance (SPR) property of AuNPs
and the interaction between RAN and AuNPs is the base of this method. The addition of
RAN into AuNPs led to the aggregation of AuNPs. Transmission electron microscopy
(TEM) proved aggregation of AuNPs in the presence of RAN. Also, the size of the
nanoparticles distribution was evaluated by dynamic light scattering (DLS). The
parameters that affect the absorbance such as pH, type and volume of buffer, AuNPs
concentration, interaction time, ionic strength, and interfering ions were investigated
and optimized. Linear range was obtained 25-300 μgL-1 in the optimum conditions.
Also, the correlation coefficient (R2
=0.9955) and the limit of detection (LOD), and limit
of quantification (LOQ) were equal to 1.45 μgL-1, and 1.63 μgL-1, respectively. In
addition, the effect of interfering species was investigated. Eventually, the results
showed that the proposed method had a high potential for rapid, sensitive, and accurate
determination of RAN
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