Design and manufacture of electrospun wound dressing based on polyvinylpyrrolidone fibers modified with aloe vera compounds for the treatment of skin edema

Subject Areas :

seyedeh Shadi Amini Dehkordi ¹ , Nargess Aghamohamadi ² , Javad Shabani Shayeh ³

1 - M.Sc. Student of Protein Research Center, Shahid Beheshti University, Tehran, Iran
2 - Instructor of School of Chemistry, University of Tehran, Tehran, Iran
3 - Assistant Prof. of Protein Research Center, Shahid Beheshti University, Tehran, Iran.

Received: 2023-06-06 Accepted : 2023-07-02 Published : 2023-11-22

Keywords: Wound Dressing, aloe vera, Electrospinning, polyvinylpyrrolidone, skin inflammation,

Abstract :

In this research, a new type of wound dressing based on polyvinyl pyrrolidone polymer (PVP) modified by extracted compounds from aloe vera (Av) was prepared by electrospinning method. After achieving optimal preparation conditions using experimental design method, the prepared material was characterized using infrared Fourier transform spectroscopy, scanning electron microscopy, X-ray diffraction, differential scanning calorimetry analysis, and thermogravimetric analysis. The results of the studies showed that by using the optimal conditions, smooth filament of PVP without node with the diameter of about 100 nm can be achieved. PVP-Av and PVP-Av-Film fiber diameter as well as fibers with a special therapeutic coating were about 105 and 120 nm, respectively with a suitable surface to volume ratio. The results of the investigations showed that the use of polymer coating on the wound dressing not only increase its mechanical resistance, but also increase the hydrophilicity of this wound dressing. In addition, the results of biological investigations showed that this wound dressing has very little toxicity for biological cells and can be used to treat skin edema.

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