Fabrication of molecular template composite as an electrochemical sensor

Subject Areas : The Application of Chemistry in Environment

Yasna salimonnafs ¹ , Behnaz Memar Maher ² , Leila Amirkhani ³ , Fahimeh Derakhshanfard ⁴

1 - Department of Chemical Engineering, Ahar Branch, Islamic Azad University, Ahar, Iran.
2 - تبریز- ابتدای گلشهر- کوچه میلاد اول- پلاک 51
3 - 1- Department of Chemical Engineering, Ahar Branch, Islamic Azad University, Ahar, Iran.
4 - Department of Chemical Engineering, Ahar Branch, Islamic Azad University, Ahar, Iran.

Received: 2022-10-31 Accepted : 2022-11-06 Published : 2022-04-21

Keywords: Voltammetry, Reduced graphene oxide, Electropolymerization, Ceftriaxone, molecular template polymer,

Abstract :

Ceftriaxone is one of the antibiotics used to treat some infectious diseases. The wide range of applications and sensitivity in the correct use of this drug doubles the necessity of measuring this drug. Many methods including chromatography have been used to measure it. Using the voltammetry method for measuring drugs is considered a bonus because of its accuracy, speed, and reasonable price. In this research work and in the modified electrode design, reduced graphene oxide to increase the sensitivity of the electrode; molecular template polymer made with methacrylic acid and ethylene glycol dimethacrylate to increase selectivity; And the electropolymerization of diphenylamine was used to stabilize the molecular template polymer on the electrode surface and increase the sensitivity. After several optimization steps, the designed electrode was used to measure small amounts of ceftriaxone. The linear range was between 0.025-3.047 μM and the detection limit was 0.008 μM. The designed electrode was successfully used to measure ceftriaxone in pharmaceutical and biological environments.